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TRAIN-ERS SIGNED

Endoplasmic Reticulum Stress in Health and Disease

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

TRAIN-ERS project word cloud

Explore the words cloud of the TRAIN-ERS project. It provides you a very rough idea of what is the project "TRAIN-ERS" about.

cancer private excellence disorders treatment convert complementary ease career tools diagnostic esr industrial shortage markers forming cutting academic training suitable intersectoral clinicians commercial edge quantitatively train prospects clinical combined hampered strategies enhanced er skills endoplasmic stress pathology syndromes mechanistically ers outlook international world young interdisciplinary validate industry creative united metabolic points drive purposes scientists esrs entrepreneurial academics stage interface therapeutic navigate careers inflammatory innovative intervention scientific biomedical quality therapies reticulum network exploited confidently trained neurodegenerative point continue sectors diseases

Project "TRAIN-ERS" data sheet

The following table provides information about the project.

Coordinator	NATIONAL UNIVERSITY OF IRELAND GALWAY Organization address address: UNIVERSITY ROAD city: Galway postcode: H91 website: www.nuigalway.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Ireland [IE]
Project website	http://www.train-ers.eu
Total cost	3˙628˙756 €
EC max contribution	3˙628˙756 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2015
Funding Scheme	MSCA-ITN-ETN
Starting year	2015
Duration (year-month-day)	from 2015-10-01 to 2019-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	NATIONAL UNIVERSITY OF IRELAND GALWAY NATIONAL UNIVERSITY OF IRELAND GALWAY Organization address address: UNIVERSITY ROAD city: Galway postcode: H91 website: www.nuigalway.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (Galway)	coordinator	797˙023.00
2	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	525˙751.00
3	KATHOLIEKE UNIVERSITEIT LEUVEN KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: OUDE MARKT 13 city: LEUVEN postcode: 3000 website: www.kuleuven.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LEUVEN)	participant	501˙120.00
4	IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ website: http://www.imperial.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	273˙287.00
5	RANDOX TEORANTA RANDOX TEORANTA Organization address address: AN CLOCHAN LIATH city: DONEGALL postcode: F94 TV06 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DONEGALL)	participant	265˙674.00
6	GOETEBORGS UNIVERSITET GOETEBORGS UNIVERSITET Organization address address: VASAPARKEN city: GOETEBORG postcode: 405 30 website: www.gu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (GOETEBORG)	participant	263˙659.00
7	LUDWIG BOLTZMANN GESELLSCHAFT OSTERREICHISCHE VEREINIGUNG ZUR FORDERUNG DER WISSENSCHAFTLICHEN FORSCHUNG LUDWIG BOLTZMANN GESELLSCHAFT OSTERREICHISCHE VEREINIGUNG ZUR FORDERUNG DER WISSENSCHAFTLICHEN FORSCHUNG Organization address address: NUSSDORFER STRASSE 64/6 city: WIEN postcode: 1090 website: http://www.lbitrauma.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	255˙934.00
8	JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN Organization address address: THEODOR W ADORNO PLATZ 1 city: FRANKFURT AM MAIN postcode: 60323 website: www.uni-frankfurt.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (FRANKFURT AM MAIN)	participant	249˙216.00
9	UNIVERSITAET STUTTGART UNIVERSITAET STUTTGART Organization address address: KEPLERSTRASSE 7 city: STUTTGART postcode: 70174 website: www.uni-stuttgart.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (STUTTGART)	participant	249˙216.00
10	FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE Organization address address: AVENIDA GRAN VIA HOSPITALET 199-203 city: L'HOSPITALET DE LLOBREGAT postcode: 8908 website: www.idibell.cat contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (L'HOSPITALET DE LLOBREGAT)	participant	247˙872.00
11	OPTIMATA LTD OPTIMATA LTD Organization address address: 20 ZICHRON YAA'KOV ST. city: TEL AVIV postcode: 6299920 website: www.optimata.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (TEL AVIV)	participant	0.00
12	ROYAL COLLEGE OF SURGEONS IN IRELAND ROYAL COLLEGE OF SURGEONS IN IRELAND Organization address address: Saint Stephen's Green 123 city: DUBLIN postcode: 2 website: www.rcsi.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	participant	0.00
13	BioScale, Inc BioScale, Inc Organization address address: 4 Maguire Road city: Lexington postcode: MA 02421 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (Lexington)	partner	0.00
14	Carpmaels & Ransford Carpmaels & Ransford Organization address address: One Southampton Row city: London postcode: WC1B 5HA website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (London)	partner	0.00
15	Lalui Leadership Lalui Leadership Organization address address: Ponesicka 1709 city: HLUBOKA NAD VLTAVOU postcode: 37341 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (HLUBOKA NAD VLTAVOU)	partner	0.00
16	MANNKIND CORPORATION MANNKIND CORPORATION Organization address address: NORTH AVENUE PAINE 28903 city: VALENCIA postcode: 91355 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (VALENCIA)	partner	0.00
17	RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN Organization address address: TEMPLERGRABEN 55 city: AACHEN postcode: 52062 website: www.rwth-aachen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (AACHEN)	partner	0.00
18	UNIVERSITATSKLINIKUM HEIDELBERG UNIVERSITATSKLINIKUM HEIDELBERG Organization address address: IM NEUENHEIMER FELD 672 city: HEIDELBERG postcode: 69120 website: www.klinikum.uni-heidelberg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	partner	0.00

Map

Project objective

Endoplasmic reticulum (ER) stress is emerging as a common feature in the pathology of numerous diseases including cancer, neurodegenerative disorders, metabolic syndromes and inflammatory diseases. Thus ER stress represents a potential therapeutic intervention point to be exploited to develop novel therapies, diagnostic tools and markers for these diseases. However, exploitation is hampered by the shortage of scientists with interdisciplinary training that can navigate with ease between the academic, industrial and clinical sectors, and that have the scientific and complementary skills, together with an innovative outlook, to convert research findings into commercial and clinical applications. This proposal will bring young researchers together with world-leading academics, clinicians and industry personnel, who are united in (1) their goal of forming a network of excellence aimed at understanding the ER stress response mechanistically and quantitatively and (2) applying this understanding to identify and validate the most suitable intervention points in order to provide innovative knowledge-driven strategies for the treatment of ER stress-associated diseases. The TRAIN-ERS network will provide early stage researchers (ESRs) with high quality scientific and complementary skills training combined with international, intersectoral work experience. This will produce highly trained, innovative, creative and entrepreneurial ESRs with greatly enhanced career prospects, who will continue to advance the state of the art in the Biomedical field in their further careers, and will confidently navigate at the interface of academic, clinical and private sector research. The TRAIN-ERS research programme will provide the ESR’s with the knowledge and the cutting edge scientific and technical skills that will drive our understanding and exploitation of the ER stress response for therapeutic and diagnostic purposes.

Deliverables

List of deliverables.
TRAIN-ERS Facebook and Twitter accounts	Websites, patent fillings, videos etc.	2019-05-07 19:21:22
ESR recruitment	Documents, reports	2019-05-07 19:21:22
Website and data sharing platform	Websites, patent fillings, videos etc.	2019-05-07 19:21:22

Take a look to the deliverables list in detail: detailed list of TRAIN-ERS deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Annika Hantusch, Kushal K. Das, Ana J. GarcÃa-SÃ¡ez, Thomas Brunner, Markus Rehm Bax retrotranslocation potentiates Bcl-xLâ€™s antiapoptotic activity and is essential for switch-like transitions between MOMP competency and resistance published pages: , ISSN: 2041-4889, DOI: 10.1038/s41419-018-0464-6	Cell Death & Disease 9/4	2019-10-08
2018	J. Catharina Duvigneau, Andreia LuÃs, Adrienne M. Gorman, Afshin Samali, Doris Kaltenecker, Richard Moriggl, Andrey V. Kozlov Crosstalk between inflammatory mediators and endoplasmic reticulum stress in liver diseases published pages: , ISSN: 1043-4666, DOI: 10.1016/j.cyto.2018.10.018	Cytokine	2019-10-07
2018	Doris Kaltenecker, Madeleine Themanns, Kristina M. Mueller, Katrin Spirk, Tobias Suske, Olaf Merkel, Lukas Kenner, Andreia LuÃs, Andrey Kozlov, Johannes Haybaeck, Mathias MÃ¼ller, Xiaonan Han, Richard Moriggl Hepatic growth hormone - JAK2 - STAT5 signalling: Metabolic function, non-alcoholic fatty liver disease and hepatocellular carcinoma progression published pages: , ISSN: 1043-4666, DOI: 10.1016/j.cyto.2018.10.010	Cytokine	2019-10-07
2019	Joanna Obacz, Tony Avril, Camila Rubio-PatiÃ±o, Jozef P. Bossowski, Aeid Igbaria, Jean-Ehrland Ricci, Eric Chevet Regulation of tumor-stroma interactions by the unfolded protein response published pages: 279-296, ISSN: 1742-464X, DOI: 10.1111/febs.14359	The FEBS Journal 286/2	2019-10-07
2018	Camila Rubio-PatiÃ±o, Jozef P. Bossowski, Eric Chevet, Jean-Ehrland Ricci Reshaping the Immune Tumor Microenvironment Through IRE1 Signaling published pages: 607-614, ISSN: 1471-4914, DOI: 10.1016/j.molmed.2018.05.005	Trends in Molecular Medicine 24/7	2019-10-07
2018	Alexandra Papaioannou, Arisa Higa, GwÃ©naÃ«le JÃ©gou, Florence Jouan, Raphael Pineau, Laure Saas, Tony Avril, Olivier Pluquet, Eric Chevet Alterations of EDEM 1 functions enhance ATF 6 proâ€survival signaling published pages: 4146-4164, ISSN: 1742-464X, DOI: 10.1111/febs.14669	The FEBS Journal 285/22	2019-10-03
2019	Antonio Carlesso, Leif A. Eriksson Selective Inhibition of IRE1 Signalling mediated by MKC9989: New Insights from Molecular Docking and Molecular Dynamics Simulations published pages: 3199-3203, ISSN: 2365-6549, DOI: 10.1002/slct.201900810	ChemistrySelect 4/11	2019-10-03
2019	Mohamed Mahameed, Thomas Wilhelm, Odai Darawshi, Akram Obiedat, Weiss-Sadan Tommy, Chetan Chintha, Thomas Schubert, Afshin Samali, Eric Chevet, Leif A. Eriksson, Michael Huber, Boaz Tirosh The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors published pages: , ISSN: 2041-4889, DOI: 10.1038/s41419-019-1523-3	Cell Death & Disease 10/4	2019-10-03
2019	Amado Carreras-Sureda, FabiÃ¡n JaÃ±a, Hery Urra, Sylvere Durand, David E. Mortenson, Alfredo Sagredo, Galdo Bustos, Younis Hazari, Eva Ramos-FernÃ¡ndez, Maria L. Sassano, Philippe PihÃ¡n, Alexander R. van Vliet, MatÃas GonzÃ¡lez-Quiroz, Angie K. Torres, Cheril Tapia-Rojas, Martijn Kerkhofs, RubÃ©n Vicente, Randal J. Kaufman, Nibaldo C. Inestrosa, Christian Gonzalez-Billault, R. Luke Wiseman, Patr Non-canonical function of IRE1Î± determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics published pages: 755-767, ISSN: 1465-7392, DOI: 10.1038/s41556-019-0329-y	Nature Cell Biology 21/6	2019-10-03
2019	Marion Maurel, Joanna Obacz, Tony Avril, Yongâ€Ping Ding, Olga Papadodima, Xavier Treton, Fanny Daniel, Eleftherios Pilalis, Johanna HÃ¶rberg, Wenyang Hou, Marieâ€Claude Beauchamp, Julien Tourneurâ€Marsille, Dominique Cazalsâ€Hatem, Lucia Sommerova, Afshin Samali, Jan Tavernier, Roman Hrstka, AurÃ©lien Dupont, Delphine Fessart, FrÃ©dÃ©ric Delom, Martin E Fernandezâ€Zapico, Gregor Jansen, Leif Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation published pages: e10120, ISSN: 1757-4676, DOI: 10.15252/emmm.201810120	EMBO Molecular Medicine 11/6	2019-10-03
2018	Antonio Carlesso, Chetan Chintha, Adrienne M. Gorman, Afshin Samali, Leif A. Eriksson Binding Analysis of the Inositol-Requiring Enzyme 1 Kinase Domain published pages: 13313-13322, ISSN: 2470-1343, DOI: 10.1021/acsomega.8b01404	ACS Omega 3/10	2019-10-03
2019	Behnaz Ahangarian Abhari, Nicole McCarthy, Marie Le Berre, Michelle Kilcoyne, Lokesh Joshi, Patrizia Agostinis, Simone Fulda Smac mimetic suppresses tunicamycin-induced apoptosis via resolution of ER stress published pages: , ISSN: 2041-4889, DOI: 10.1038/s41419-019-1381-z	Cell Death & Disease 10/3	2019-10-03
2019	Antonio Carlesso, Chetan Chintha, Adrienne M. Gorman, Afshin Samali, Leif A. Eriksson Merits and pitfalls of conventional and covalent docking in identifying new hydroxyl aryl aldehyde like compounds as human IRE1 inhibitors published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-39939-z	Scientific Reports 9/1	2019-10-03
2017	T Avril, E VaulÃ©on, E Chevet Endoplasmic reticulum stress signaling and chemotherapy resistance in solid cancers published pages: e373-e373, ISSN: 2157-9024, DOI: 10.1038/oncsis.2017.72	Oncogenesis 6/8	2019-10-03
2018	Josip Skoko, Jan RoÅ¾anc, Emilie M. Charles, Leonidas G. Alexopoulos, Markus Rehm Post-treatment de-phosphorylation of p53 correlates with dasatinib responsiveness in malignant melanoma published pages: , ISSN: 1471-2121, DOI: 10.1186/s12860-018-0180-1	BMC Cell Biology 19/1	2019-10-03
2019	Behnaz Ahangarian Abhari, Nicole McCarthy, Patrizia Agostinis, Simone Fulda NF-ÎºB contributes to Smac mimetic-conferred protection from tunicamycin-induced apoptosis published pages: 269-277, ISSN: 1360-8185, DOI: 10.1007/s10495-018-1507-2	Apoptosis 24/3-4	2019-10-03
2017	Tony Avril, Amandine Etcheverry, RaphaÃ«l Pineau, Joanna Obacz, GwÃ©naÃ«le Jegou, Florence Jouan, Pierre-Jean Le Reste, Masumeh Hatami, Rivka R. Colen, Brett L. Carlson, Paul A. Decker, Jann N. Sarkaria, Elodie VaulÃ©on, Dan Cristian Chiforeanu, Anne Clavreul, Jean Mosser, Eric Chevet, VÃ©ronique Quillien CD90 Expression Controls Migration and Predicts Dasatinib Response in Glioblastoma published pages: 7360-7374, ISSN: 1078-0432, DOI: 10.1158/1078-0432.ccr-17-1549	Clinical Cancer Research 23/23	2019-10-03
2018	Cynthia Lebeaupin, Deborah VallÃ©e, Younis Hazari, Claudio Hetz, Eric Chevet, BÃ©atrice Bailly-Maitre Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease published pages: 927-947, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2018.06.008	Journal of Hepatology 69/4	2019-10-03
2019	Doultsinos D, McMahon M, Voutetaki K, Obacz J, Pineau R, Jouan F, Le Reste P-J, Obiedat A, Samal J, Patterson JB, Zheng Q, Samali A, Pandit A, Tirosh B, Chatziioannou A, Chevet E, Avril T. Constitutive IRE1Î± signaling maintains glioblastoma cell differentiation published pages: , ISSN: , DOI: 10.1101/59463	BioRXiv	2019-10-03
2019	Dimitrios Doultsinos, Mari McMahon, Konstantinos Voutetakis, Joanna Obacz, Raphael Pineau, Florence Jouan, Pierre-Jean Le Reste, Akram Obiedat, Juhi Samal, John B. Patterson, Qingping Zheng, Afshin Samali, Abhay Pandit, Boaz Tirosh, Aristotelis Chatziioannou, View ORCID ProfileEric Chevet, Tony Avril Control of glioblastoma differentiated-to-stem cell reprogramming by IRElÎ±/XBPls signaling published pages: , ISSN: , DOI: 10.1101/594630	BioRXiv	2019-10-03
2018	StÃ©phanie Lhomond, Tony Avril, Nicolas Dejeans, Konstantinos Voutetakis, Dimitrios Doultsinos, Mari McMahon, RaphaÃ«l Pineau, Joanna Obacz, Olga Papadodima, Florence Jouan, Heloise Bourien, Marianthi Logotheti, GwÃ©naÃ«le JÃ©gou, NÃ©stor Pallaresâ€Lupon, Kathleen Schmit, Pierreâ€Jean Le Reste, Amandine Etcheverry, Jean Mosser, Kim Barroso, Elodie VaulÃ©on, Marion Maurel, Afshin Samali, John B P Dual IRE1 RNase functions dictate glioblastoma development published pages: e7929, ISSN: 1757-4676, DOI: 10.15252/emmm.201707929	EMBO Molecular Medicine 10/3	2019-07-08
2018	L. Montibeller, J. de Belleroche Amyotrophic lateral sclerosis (ALS) and Alzheimerâ€™s disease (AD) are characterised by differential activation of ER stress pathways: focus on UPR target genes published pages: , ISSN: 1355-8145, DOI: 10.1007/s12192-018-0897-y	Cell Stress and Chaperones	2019-07-08
2018	Alexander R. van Vliet, Maria Livia Sassano, Patrizia Agostinis The Unfolded Protein Response and Membrane Contact Sites: Tethering as a Matter of Life and Death? published pages: 251525641877051, ISSN: 2515-2564, DOI: 10.1177/2515256418770512	Contact 1	2019-05-07
2018	Aitor Almanza, Antonio Carlesso, Chetan Chintha, Stuart Creedican, Dimitrios Doultsinos, Brian Leuzzi, Andreia LuÃs, Nicole McCarthy, Luigi Montibeller, Sanket More, Alexandra Papaioannou, Franziska PÃ¼schel, Maria Livia Sassano, Josip Skoko, Patrizia Agostinis, Jackie de Belleroche, Leif A. Eriksson, Simone Fulda, Adrienne M. Gorman, Sandra Healy, Andrey Kozlov, Cristina MuÃ±oz-Pinedo, Markus Rehm, Eric Chevet, Afshin Samali Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications published pages: , ISSN: 1742-464X, DOI: 10.1111/febs.14608	The FEBS Journal	2019-05-07
2018	Rola Jaafar, Katarzyna Mnich, Sarah Dolan, Jennifer Hillis, Aitor Almanza, Susan E. Logue, Afshin Samali, Adrienne M. Gorman RIP2 enhances cell survival by activation of NF-Ä¸B in triple negative breast cancer cells published pages: 115-121, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2018.02.034	Biochemical and Biophysical Research Communications 497/1	2019-05-07
2018	Susan E. Logue, Eoghan P. McGrath, Patricia Cleary, Stephanie Greene, Katarzyna Mnich, Aitor Almanza, Eric Chevet, RÃ³isÃn M. Dwyer, Anup Oommen, Patrick Legembre, Florence Godey, Emma C. Madden, Brian Leuzzi, Joanna Obacz, Qingping Zeng, John B. Patterson, Richard JÃ¤ger, Adrienne M. Gorman, Afshin Samali Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-05763-8	Nature Communications 9/1	2019-05-07

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