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ALBINO SIGNED

Effect of ALlopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcome

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

ALBINO project word cloud

Explore the words cloud of the ALBINO project. It provides you a very rough idea of what is the project "ALBINO" about.

western reperfusion brain administered life therapy world birth neurodevelopmental opportunity generation safety resonance incidence hypoxic suffer became give imaging near strategies magnetic risk inhibitor injury xanthine neonates immediately human intensive damage biomarkers consequently born neuroprotective metabolism experimental validate beside despite warranted asphyxia ischemia neonatal hie impairment reduces outcome insults oxidase treatment children die biochemistry oxygen ischemic hypothermic extend death trial allopurinol hypothermia animal drugs 45 50 births possibly care pharmacokinetics primary encephalopathy interventions infants disability preventive additional radicals efficacy effect electroencephalogramms perinatal

Project "ALBINO" data sheet

The following table provides information about the project.

Coordinator	EBERHARD KARLS UNIVERSITAET TUEBINGEN Organization address address: GESCHWISTER-SCHOLL-PLATZ city: TUEBINGEN postcode: 72074 website: www.uni-tuebingen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	http://www.albino-study.eu
Total cost	6˙307˙599 €
EC max contribution	5˙994˙030 € (95%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-PHC-2015-two-stage
Funding Scheme	RIA
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2020-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	EBERHARD KARLS UNIVERSITAET TUEBINGEN EBERHARD KARLS UNIVERSITAET TUEBINGEN Organization address address: GESCHWISTER-SCHOLL-PLATZ city: TUEBINGEN postcode: 72074 website: www.uni-tuebingen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (TUEBINGEN)	coordinator	2˙029˙252.00
2	ACE PHARMACEUTICALS BV ACE PHARMACEUTICALS BV Organization address address: SCHEPENVELD 41 city: ZEEWOLDE postcode: 3891 ZK website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ZEEWOLDE)	participant	1˙461˙536.00
3	UNIVERSITAIR MEDISCH CENTRUM UTRECHT UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	participant	637˙735.00
4	FUNDACION PARA LA INVESTIGACION DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA FUNDACION PARA LA INVESTIGACION DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA Organization address address: AV FERNANDO ABRIL MARTORELL 106 city: VALENCIA postcode: 46026 website: http://www.iislafe.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (VALENCIA)	participant	233˙464.00
5	KATHOLIEKE UNIVERSITEIT LEUVEN KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: OUDE MARKT 13 city: LEUVEN postcode: 3000 website: www.kuleuven.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LEUVEN)	participant	210˙313.00
6	OSLO UNIVERSITETSSYKEHUS HF OSLO UNIVERSITETSSYKEHUS HF Organization address address: KIRKEVEIEN 166 TARNBYGGET city: OSLO postcode: 450 website: http://www.oslo-universitetssykehus.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (OSLO)	participant	207˙489.00
7	UNIVERSITA DEGLI STUDI DI UDINE UNIVERSITA DEGLI STUDI DI UDINE Organization address address: VIA PALLADIO 8 city: UDINE postcode: 33100 website: www.uniud.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (UDINE)	participant	196˙432.00
8	HELSINGIN JA UUDENMAAN SAIRAANHOITOPIIRIN KUNTAYHTYMÄ HELSINGIN JA UUDENMAAN SAIRAANHOITOPIIRIN KUNTAYHTYMÄ Organization address address: STENBACKINKATU 9 city: HELSINKI postcode: 29 website: www.hus.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (HELSINKI)	participant	179˙550.00
9	TECHNISCHE UNIVERSITAET DRESDEN TECHNISCHE UNIVERSITAET DRESDEN Organization address address: HELMHOLTZSTRASSE 10 city: DRESDEN postcode: 1069 website: http://www.tu-dresden.de/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DRESDEN)	participant	171˙756.00
10	UNIWERSYTET MEDYCZNY IM KAROLA MARCINKOWSKIEGO W POZNANIU UNIWERSYTET MEDYCZNY IM KAROLA MARCINKOWSKIEGO W POZNANIU Organization address address: UL. FREDRY 10 city: POZNAN postcode: 61-701 website: www.ump.edu.pl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PL (POZNAN)	participant	159˙576.00
11	UNIVERSIDADE DO PORTO UNIVERSIDADE DO PORTO Organization address address: PRACA GOMES TEIXEIRA city: PORTO postcode: 4099 002 website: http://www.up.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (PORTO)	participant	143˙842.00
12	MEDIZINISCHE UNIVERSITAET WIEN MEDIZINISCHE UNIVERSITAET WIEN Organization address address: SPITALGASSE 23 city: WIEN postcode: 1090 website: www.meduniwien.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	136˙384.00
13	HELSINGIN YLIOPISTO HELSINGIN YLIOPISTO Organization address address: YLIOPISTONKATU 3 city: HELSINGIN YLIOPISTO postcode: 14 website: www.helsinki.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (HELSINGIN YLIOPISTO)	participant	127˙875.00
14	TARTU ULIKOOL TARTU ULIKOOL Organization address address: ULIKOOLI 18 city: TARTU postcode: 51005 website: www.ut.ee contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EE (TARTU)	participant	98˙426.00
15	OSTRAVSKA UNIVERZITA OSTRAVSKA UNIVERZITA Organization address address: DVORAKOVA 7 city: OSTRAVA postcode: 701 03 website: www.osu.cz contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (OSTRAVA)	participant	395.00
16	UNIVERSITAT ZURICH UNIVERSITAT ZURICH Organization address address: RAMISTRASSE 71 city: ZURICH postcode: 8006 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZURICH)	participant	0.00

Map

Project objective

Neonatal hypoxic-ischemic encephalopathy (HIE) is a major cause of death or long-term disability in infants born at term in the western world, affecting about 1-4 per 1.000 life births and consequently about 5-20.000 infants per year in Europe. Hypothermic treatment became the only established therapy to improve outcome after perinatal hypoxic-ischemic insults. Despite hypothermia and neonatal intensive care, 45-50% of affected children die or suffer from long-term neurodevelopmental impairment. Additional neuroprotective interventions, beside hypothermia, are warranted to further improve their outcome. Allopurinol is a xanthine oxidase inhibitor and reduces the production of oxygen radicals and brain damage in experimental, animal, and early human studies of ischemia and reperfusion. This project aims to evaluate the efficacy and safety of allopurinol administered immediately after birth to near-term infants with HIE in addition to hypothermic treatment. Beyond this primary objective, the project will provide information on the effect of hypothermia on pharmacokinetics of drugs with a similar metabolism as allopurinol in neonates. Furthermore it will give the opportunity to further develop and validate biomarkers for neonatal brain injury using advanced magnetic resonance imaging, biochemistry, and electroencephalogramms, which will then be available for future studies testing neuroprotective interventions. Finally, this trial will extend our knowledge about incidence of and risk factors for perinatal asphyxia and HIE possibly enabling generation of more preventive strategies for the future.

Deliverables

List of deliverables.
D10.2 ISRCTN or NCT number	Documents, reports	2020-04-07 20:18:38

Take a look to the deliverables list in detail: detailed list of ALBINO deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Christian A. Maiwald, Kim V. Annink, Mario RÃ¼diger, Manon J. N. L. Benders, Frank van Bel, Karel Allegaert, Gunnar Naulaers, Dirk Bassler, Katrin KlebermaÃŸ-Schrehof, Maximo Vento, Hercilia GuimarÃ£es, Tom Stiris, Luigi Cattarossi, Marjo MetsÃ¤ranta, Sampsa Vanhatalo, Jan Mazela, Tuuli Metsvaht, Yannique Jacobs, Axel R. Franz Effect of allopurinol in addition to hypothermia treatment in neonates for hypoxic-ischemic brain injury on neurocognitive outcome (ALBINO): study protocol of a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III) published pages: 210, ISSN: 1471-2431, DOI: 10.1186/s12887-019-1566-8	BMC Pediatrics 19/1	2020-04-07
2018	Kim V. Annink, Axel R. Franz, Jan B. Derks, Mario RÃ¼diger, Frank van Bel, Manon J.N.L. Benders Allopurinol: Old Drug, New Indication in Neonates? published pages: 5935-5942, ISSN: 1381-6128, DOI: 10.2174/1381612823666170918123307	Current Pharmaceutical Design 23/38	2020-04-07

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