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AEGIS SIGNED

Accelerated Early staGe drug diScovery

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

AEGIS project word cloud

Explore the words cloud of the AEGIS project. It provides you a very rough idea of what is the project "AEGIS" about.

stage tackle registrations fellows discovery combining outbreak young asia area rights rare individual valuable takes pharmaceutical efficiency establishing planning joins upcoming host schools career academic skills risk property industries industry academia intellectual stakeholders first training drug communication network seed scientific intersectoral companies employability sustainable additional potentially dramatically platform added drugs students fund diseases illustrated falling difficult innovative curriculum validation techniques disciplinary itn complementary place secondments protein interactions ebola generation biggest environment decades principal structured workforce cross networking aegis perspectives skilled innovation doctoral

Project "AEGIS" data sheet

The following table provides information about the project.

Coordinator	HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH Organization address address: INGOLSTADTER LANDSTRASSE 1 city: NEUHERBERG postcode: 85764 website: www.helmholtz-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	http://www.aegis-itn.eu/
Total cost	3˙836˙995 €
EC max contribution	3˙836˙995 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2015
Funding Scheme	MSCA-ITN-ETN
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2019-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH Organization address address: INGOLSTADTER LANDSTRASSE 1 city: NEUHERBERG postcode: 85764 website: www.helmholtz-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (NEUHERBERG)	coordinator	498˙432.00
2	INSTITUT PASTEUR INSTITUT PASTEUR Organization address address: RUE DU DOCTEUR ROUX 25-28 city: PARIS CEDEX 15 postcode: 75724 website: http://www.pasteur.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS CEDEX 15)	participant	525˙751.00
3	RIJKSUNIVERSITEIT GRONINGEN RIJKSUNIVERSITEIT GRONINGEN Organization address address: Broerstraat 5 city: GRONINGEN postcode: 9712CP website: www.rug.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (GRONINGEN)	participant	510˙748.00
4	PHILIPPS UNIVERSITAET MARBURG PHILIPPS UNIVERSITAET MARBURG Organization address address: BIEGENSTRASSE 10 city: MARBURG postcode: 35037 website: www.uni-marburg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MARBURG)	participant	498˙432.00
5	EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Organization address address: Raemistrasse 101 city: ZUERICH postcode: 8092 website: https://www.ethz.ch/de.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZUERICH)	participant	265˙226.00
6	NOVARTIS PHARMA AG NOVARTIS PHARMA AG Organization address address: LICHTSTRASSE 35 city: BASEL postcode: 4056 website: www.novartis.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BASEL)	participant	265˙226.00
7	ASTRAZENECA AB ASTRAZENECA AB Organization address address: Vastra Maelarhamnen city: SODERTAELJE postcode: 151 85 website: www.astrazeneca.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (SODERTAELJE)	participant	263˙659.00
8	RIDGEVIEW INSTRUMENTS AB RIDGEVIEW INSTRUMENTS AB Organization address address: SKILLSTA 4 city: VANGE postcode: 74020 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (VANGE)	participant	263˙659.00
9	UPPSALA UNIVERSITET UPPSALA UNIVERSITET Organization address address: VON KRAEMERS ALLE 4 city: UPPSALA postcode: 751 05 website: www.uu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (UPPSALA)	participant	263˙659.00
10	GIOTTO BIOTECH SRL GIOTTO BIOTECH SRL Organization address address: VIA MADONNA DEL PIANO 6 city: SESTO FIORENTINO FI postcode: 50019 website: www.giottobiotech.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (SESTO FIORENTINO FI)	participant	258˙061.00
11	UNIWERSYTET JAGIELLONSKI UNIWERSYTET JAGIELLONSKI Organization address address: Ul. Golebia 24 city: KRAKOW postcode: 31007 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PL (KRAKOW)	participant	224˙137.00
12	Astex Astex Organization address address: Hermanos Becquer 7 city: MADRID postcode: 28006 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	partner	0.00
13	ENAMINE LIMITED LIABILITY COMPANY,RESEARCH AND PRODUCTION ENTERPRISE ENAMINE LIMITED LIABILITY COMPANY,RESEARCH AND PRODUCTION ENTERPRISE Organization address address: 78 CHERVONOTKATSKA STR. city: KYIV postcode: 2094 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UA (KYIV)	partner	0.00
14	EURORDIS - EUROPEAN ORGANISATION FOR RARE DISEASES ASSOCIATION EURORDIS - EUROPEAN ORGANISATION FOR RARE DISEASES ASSOCIATION Organization address address: RUE DIDOT 96 city: Paris postcode: 75014 website: www.eurordis.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (Paris)	partner	0.00
15	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	partner	0.00
16	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: MUENCHEN postcode: 80539 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	partner	0.00
17	Patentanwalt Dietmar Forstmeyer Patentanwalt Dietmar Forstmeyer Organization address address: Oberanger 32 city: München postcode: 80331 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (München)	partner	0.00
18	RUHR-UNIVERSITAET BOCHUM RUHR-UNIVERSITAET BOCHUM Organization address address: UNIVERSITAETSSTRASSE 150 city: BOCHUM postcode: 44801 website: www.rub.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BOCHUM)	partner	0.00
19	TECHNISCHE UNIVERSITAET MUENCHEN TECHNISCHE UNIVERSITAET MUENCHEN Organization address address: Arcisstrasse 21 city: MUENCHEN postcode: 80333 website: www.tu-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	partner	0.00
20	TECHNISCHE UNIVERSITEIT EINDHOVEN TECHNISCHE UNIVERSITEIT EINDHOVEN Organization address address: GROENE LOPER 3 city: EINDHOVEN postcode: 5612 AE website: www.tue.nl/en contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (EINDHOVEN)	partner	0.00
21	TelesisPharma TelesisPharma Organization address address: Hofstraat, 22 city: Groningen postcode: 9712 JC website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (Groningen)	partner	0.00
22	UNIVERSITA DEGLI STUDI DI FIRENZE UNIVERSITA DEGLI STUDI DI FIRENZE Organization address address: Piazza San Marco 4 city: Florence postcode: 50121 website: http://www.unifi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (Florence)	partner	0.00
23	UNIVERSITY OF PITTSBURGH UNIVERSITY OF PITTSBURGH Organization address address: University Place 123 city: PITTSBURGH postcode: 15213 website: www.pitt.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (PITTSBURGH)	partner	0.00
24	UNIWERSYTET JAGIELLONSKI UNIWERSYTET JAGIELLONSKI Organization address address: Ul. Golebia 24 city: Krakow postcode: 31007 website: www.uj.edu.pl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PL (Krakow)	partner	0.00
25	UNTERNEHMERTUM GMBH UNTERNEHMERTUM GMBH Organization address address: LICHTENBERGSTRASSE 6 city: GARCHING postcode: 85748 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (GARCHING)	partner	0.00

Map

Project objective

The development of effective novel drugs - especially for rare and neglected diseases - is one of the biggest challenges of the upcoming decades, as illustrated by the recent Ebola outbreak. Moreover, European innovation in new drug registrations is dramatically falling behind compared to the US and Asia. The principal aim of the AEGIS ITN is to implement the first comprehensive, intersectoral cross-disciplinary and structured curriculum for doctoral students in the European Research Area by establishing a unique training platform for the next generation of European researchers in early drug discovery. A significant added value is provided through networking with key European pharmaceutical companies. A key research aim of AEGIS is improving the efficiency and success of early stage drug development by combining innovative methods and techniques to tackle difficult but promising targets (i.e. protein-protein interactions), as potentially valuable drug targets are often neglected due to the high risk associated with their validation. The consortium joins leading academic and industry researchers in an open innovation environment for innovative drug development in Europe. It is supported by several additional partners and stakeholders in the field. Integrated training of the fellows takes place at the host institute and by secondments, research schools and individual training within the AEGIS network. The scientific training includes complementary skills, management, intellectual property rights, fund raising, communication and career planning. AEGIS will improve the availability of a highly skilled workforce for European industries and research, greatly enhance the employability and the career perspectives of young researchers for academia as well as for industry, and will be the seed of a sustainable development in innovative drug discovery, in particular for rare and neglected diseases.

Deliverables

List of deliverables.
Optimized library	Documents, reports	2019-07-09 16:31:29
Web-based MCR platform	Documents, reports	2019-07-09 16:31:29
AEGIS Newsletter 1	Websites, patent fillings, videos etc.	2019-07-09 16:31:29
Schools 1	Documents, reports	2019-07-09 16:31:29
Virtual screening & de novo design	Documents, reports	2019-07-09 16:31:29
Announcement of the Supervisory Board	Other	2019-07-09 16:31:29
Method development induced pockets	Documents, reports	2019-07-09 16:31:29
Report 1 about Public Engagement Activities	Other	2019-07-09 16:31:29

Take a look to the deliverables list in detail: detailed list of AEGIS deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2020	Markella Konstantinidou, Francesca Magari, Fandi Sutanto, JÃ¶rg Haupenthal, Varsha R. Jumde, M. Yagiz Ãœnver, Andreas Heine, Carlos Jamie Camacho, Anna K. H. Hirsch, Gerhard Klebe, Alexander DÃ¶mling Rapid Discovery of Aspartyl Protease Inhibitors Using an Anchoring Approach published pages: online, ISSN: 1860-7179, DOI: 10.1002/cmdc.202000024	ChemMedChem online	2020-04-01
2020	Softley CA, Zak KM, Bostock MJ, Fino R, Zhoua RX, Kolonko M, Mejdi-Nitiu R, Meyer H, Sattler M, Popowic GM Structure and molecular recognition mechanism of IMP-13 metallo-Î²-lactamase published pages: , ISSN: 1098-6596, DOI:	Antimicrobial Agents and Chemotherapy accepted	2020-04-01
2020	R. Fino, R. Byrne, C.A. Softley, M. Sattler, G. Schneider, G.M. Popowicz Introducing the CSP Analyzer: A novel Machine Learning-based application for automated analysis of two-dimensional NMR spectra in NMR fragment-based screening published pages: 603-611, ISSN: 2001-0370, DOI: 10.1016/j.csbj.2020.02.015	Computational and Structural Biotechnology Journal 18	2020-03-31
2020	Sara Marie Ã˜ie Solbak, Jie Zang, Dilip Narayanan, Lars Jakobsen HÃ¸j, Saskia Bucciarelli, Charlotte Softley, Sebastian Meier, Annette Eva Langkilde, Charlotte Held Gotfredsen, Michael Sattler, Anders Bach Developing Inhibitors of the p47phoxâ€“p22phox Proteinâ€“Protein Interaction by Fragment-Based Drug Discovery published pages: 1156-1177, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.9b01492	Journal of Medicinal Chemistry 63/3	2020-03-31
2019	Qian Wang, Angelina Osipyan, Markella Konstantinidou, Roberto Butera, Kumchok C. Mgimpatsang, Svitlana V. Shishkina, Alexander DÃ¶mling Pd-Catalyzed de Novo Assembly of Diversely Substituted Indole-Fused Polyheterocycles published pages: 12148-12156, ISSN: 0022-3263, DOI: 10.1021/acs.joc.9b01258	The Journal of Organic Chemistry 84/18	2020-03-31
2018	Varsha R. Jumde, Milon Mondal, Robin M. Gierse, M. Yagiz Unver, Francesca Magari, Roos C. W. vanâ€…Lier, Andreas Heine, Gerhard Klebe, Anna K. H. Hirsch Design and Synthesis of Bioisosteres of Acylhydrazones as Stable Inhibitors of the Aspartic Protease Endothiapepsin published pages: 2266-2270, ISSN: 1860-7179, DOI: 10.1002/cmdc.201800446	ChemMedChem 13/21	2020-03-31
2019	Ave Kuusk, JoÃ£o Filipe Neves, Kenny Bravo-Rodriguez, Anders Gunnarsson, Yasser B. Ruiz-Blanco, Michael Ehrmann, Hongming Chen, Isabelle Landrieu, Elsa Sanchez-Garcia, Helen Boyd, Christian Ottmann, Richard G. Doveston Adoption of a Turn Conformation Drives the Binding Affinity of p53 C-Terminal Domain Peptides to 14-3-3Ïƒ published pages: 262-271, ISSN: 1554-8929, DOI: 10.1021/acschembio.9b00893	ACS Chemical Biology 15/1	2020-03-31
2020	Lukas Friedrich, Ryan Byrne, Aaron Treder, Inderjeet Singh, Christoph Bauer, Thomas Gudermann, Michael Mederos y Schnitzler, Ursula Storch, Gisbert Schneider Shape Similarity by Fractal Dimensionality: An Application in the de novo Design of (âˆ’)â€Englerin A Mimetics published pages: online, ISSN: 1860-7179, DOI: 10.1002/cmdc.202000017	ChemMedChem online	2020-03-31
2018	Irene Russo Krauss, Valeria Napolitano, Luigi Petraccone, Romualdo Troisi, Vera Spiridonova, Carlo Andrea Mattia, Filomena Sica Duplex/quadruplex oligonucleotides: Role of the duplex domain in the stabilization of a new generation of highly effective anti-thrombin aptamers published pages: 1697-1705, ISSN: 0141-8130, DOI: 10.1016/j.ijbiomac.2017.10.033	International Journal of Biological Macromolecules 107	2020-03-31
2018	Ana S. Pires, ClÃ¡udia R. Marques, JoÃ£o C. EncarnaÃ§Ã£o, Ana M. Abrantes, InÃªs A. Marques, Mafalda Laranjo, Rui Oliveira, JoÃ£o E. Casalta-Lopes, Ana C. GonÃ§alves, Ana B. Sarmento-Ribeiro, Maria F. Botelho Ascorbic Acid Chemosensitizes Colorectal Cancer Cells and Synergistically Inhibits Tumor Growth published pages: online, ISSN: 1664-042X, DOI: 10.3389/fphys.2018.00911	Frontiers in Physiology 9	2020-03-31
2018	JoÃ£o Crispim EncarnaÃ§Ã£o, Ana SalomÃ© Pires, Renata Alexandra Amaral, Telmo JosÃ© GonÃ§alves, Mafalda Laranjo, JoÃ£o Eduardo Casalta-Lopes, Ana Cristina GonÃ§alves, Ana Bela Sarmento-Ribeiro, Ana Margarida Abrantes, Maria Filomena Botelho Butyrate, a dietary fiber derivative that improves irinotecan effect in colon cancer cells published pages: 183-192, ISSN: 0955-2863, DOI: 10.1016/j.jnutbio.2018.02.018	The Journal of Nutritional Biochemistry 56	2020-03-31
2018	Romualdo Troisi, Valeria Napolitano, Vera Spiridonova, Irene RussoÂ Krauss, Filomena Sica Several structural motifs cooperate in determining the highly effective anti-thrombin activity of NU172 aptamer published pages: 12177-12185, ISSN: 0305-1048, DOI: 10.1093/nar/gky990	Nucleic Acids Research 46/22	2020-03-31
2016	Irene RussoÂ Krauss, Vera Spiridonova, Andrea Pica, Valeria Napolitano, Filomena Sica Different duplex/quadruplex junctions determine the properties of anti-thrombin aptamers with mixed folding published pages: 983-991, ISSN: 0305-1048, DOI: 10.1093/nar/gkv1384	Nucleic Acids Research 44/2	2020-03-31
2020	Ekaterina L. Ratkova, Maciej Dawidowski, Valeria Napolitano, Grzegorz Dubin, Roberto Fino, Michael S. Ostertag, Michael Sattler, Grzegorz Popowicz, Igor V. Tetko Water envelope has a critical impact on the design of proteinâ€“protein interaction inhibitors published pages: \"https://pubs.r, ISSN: 1359-7345, DOI: 10.1039/c9cc07714f	Chemical Communications \"https://pubs.rsc.org/en/conte	2020-03-31
2018	Sergey Lunev, Sabine Butzloff, Atilio R. Romero, Marleen Linzke, Fernando A. Batista, Kamila A. Meissner, Ingrid B. MÃ¼ller, Alaa Adawy, Carsten Wrenger, Matthew R. Groves Oligomeric interfaces as a tool in drug discovery: Specific interference with activity of malate dehydrogenase of Plasmodium falciparum in vitro published pages: e0195011, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0195011	PLOS ONE 13/4	2019-07-09
2018	JoÃ£o Crispim EncarnaÃ§Ã£o, Tim Schulte, Adnane Achour, Hanna BjÃ¶rkelund, Karl Andersson Detecting ligand interactions in real time on living bacterial cells published pages: 4193-4201, ISSN: 0175-7598, DOI: 10.1007/s00253-018-8919-3	Applied Microbiology and Biotechnology 102/9	2019-07-09

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The information about "AEGIS" are provided by the European Opendata Portal: CORDIS opendata.