Opendata, web and dolomites

DeFiNER SIGNED

Nucleotide Excision Repair: Decoding its Functional Role in Mammals

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 DeFiNER project word cloud

Explore the words cloud of the DeFiNER project. It provides you a very rough idea of what is the project "DeFiNER" about.

organization    severity    difficulties    roles    reprogramming    expression    transmit    underlying    diverse    organism    dimensional    prioritize    cells    explained    disease    intact    functional    functionally    regulation    ner    pluripotent    proteins    linked    networks    besides    transgenic    cancer    dna    exists    repair    defects    chromatin    mammalian    series    progression    fine    heterogeneity    employ    vastly    poorly    varying    biological    aging    contributions    disorders    progeroid    primarily    faithfully    protein    maintenance    connected    insufficiently    paramount    defect    random    progeny    vivo    mice    knock    give    nucleotide    stem    transcriptional    transcription    play    tuning    mechanisms    architecture    genome    solid    clinical    mammals    dissecting    decode    remodelling    function    operate    complexes    itself    execute    unexplored    paving    tightly    gene    regard    coordinate    hormones    developmental    excision    reveals   

Project "DeFiNER" data sheet

The following table provides information about the project.

Coordinator
IDRYMA TECHNOLOGIAS KAI EREVNAS 

Organization address
address: N PLASTIRA STR 100
city: IRAKLEIO
postcode: 70013
website: www.forth.gr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Project website http://www.garinislab.gr
 Total cost 1˙995˙000 €
 EC max contribution 1˙995˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IDRYMA TECHNOLOGIAS KAI EREVNAS EL (IRAKLEIO) coordinator 1˙995˙000.00

Map

 Project objective

Genome maintenance, chromatin remodelling and transcription are tightly linked biological processes that are currently poorly understood and vastly unexplored. Nucleotide excision repair (NER) is a major DNA repair pathway that mammalian cells employ to maintain their genome intact and faithfully transmit it into their progeny. Besides cancer and aging, however, defects in NER give rise to developmental disorders whose clinical heterogeneity and varying severity can only insufficiently be explained by the DNA repair defect. Recent work reveals that NER factors play a role, in addition to DNA repair, in transcription and the three-dimensional organization of our genome. Indeed, NER factors are now known to function in the regulation of gene expression, the transcriptional reprogramming of pluripotent stem cells and the fine-tuning of growth hormones during mammalian development. In this regard, the non-random organization of our genome, chromatin and the process of transcription itself are expected to play paramount roles in how NER factors coordinate, prioritize and execute their distinct tasks during development and disease progression. At present, however, no solid evidence exists as to how NER is functionally involved in such complex processes, what are the NER-associated protein complexes and underlying gene networks or how NER factors operate within the complex chromatin architecture. This is primarily due to our difficulties in dissecting the diverse functional contributions of NER proteins in an intact organism. Here, we propose to use a unique series of knock-in, transgenic and NER progeroid mice to decode the functional role of NER in mammals, thus paving the way for understanding how genome maintenance pathways are connected to developmental defects and disease mechanisms in vivo.

 Publications

year authors and title journal last update
List of publications.
2017 Kalliopi Stratigi, Ourania Chatzidoukaki, George A. Garinis
DNA damage-induced inflammation and nuclear architecture
published pages: 17-26, ISSN: 0047-6374, DOI: 10.1016/j.mad.2016.09.008
Mechanisms of Ageing and Development 165 2020-03-17
2017 Georgia Chatzinikolaou, Zivkos Apostolou, Tamara Aid-Pavlidis, Anna Ioannidou, Ismene Karakasilioti, Giorgio L. Papadopoulos, Michalis Aivaliotis, Maria Tsekrekou, John Strouboulis, Theodore Kosteas, George A. Garinis
ERCC1–XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes
published pages: 421-432, ISSN: 1465-7392, DOI: 10.1038/ncb3499
Nature Cell Biology 19/5 2020-03-17
2016 Anna Ioannidou, Evi Goulielmaki, George A. Garinis
DNA Damage: From Chronic Inflammation to Age-Related Deterioration
published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2016.00187
Frontiers in Genetics 7 2020-03-17

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "DEFINER" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "DEFINER" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

RECON (2019)

Reprogramming Conformation by Fluorination: Exploring New Areas of Chemical Space

Read More  

DDREAMM (2020)

Dna Damage REsponse: Actionabilities, Maps and Mechanisms

Read More  

HD-Neu-Screen (2020)

HD-MEA-based Neuronal Assays and Network Analysis for Phenotypic Drug Screenings

Read More