SYNECT SIGNED
Immunological synapse derived ectosomes in T cell effector function
Total Cost €
0EC-Contrib. €
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Project "SYNECT" data sheet
The following table provides information about the project.
| Coordinator |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Project website | https://www.ndorms.ox.ac.uk/programme-grants/immunological-synapse-derived-ectosomes-in-t-cell-effector-function |
| Total cost | 2˙212˙114 € |
| EC max contribution | 2˙212˙114 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2014-ADG |
| Funding Scheme | ERC-ADG |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-11-01 to 2020-10-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD | UK (OXFORD) | coordinator | 2˙212˙114.00 |
Map
Project objective
The immunological synapse is a highly conserved scaffold for communication between immune cells built around cooperation of antigen and adhesion receptors. It often takes the form of a bull’s eye with a central cluster of antigen receptors surrounded by a ring of adhesion molecules. We have recently observed that antigen receptor coated extracellular microvesicles bud directly from the center of the immunological synapse- which we define as synaptic ectosomes. Synaptic ectosomes are transferred to the antigen- presenting cell and can generate signals after the T cell-APC synapse has dissolved. We aim to determine the composition of synaptic ectosomes, determine their fate in the antigen-presenting cell and identify approaches to manipulate their formation in vivo. The objectives will be to 1) isolate synaptic ectosomes from human T cells and determine their molecular composition; 2) determine the functional impact of synaptic ectosomes on the antigen presenting cell; and 3) use gene targeting to control the process in vivo to understand its role in T function of helper, cytotoxic and regulatory T cells. The technologies will include microscopy, proteomics, genomics, and in vivo models with constitutive and conditional gene targeting. This work will address fundamental gaps in our understanding of immune cell communication.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2017 |
Thomas Riffelmacher, Alexander Clarke, Felix C. Richter, Amanda Stranks, Sumeet Pandey, Sara Danielli, Philip Hublitz, Zhanru Yu, Errin Johnson, Tobias Schwerd, James McCullagh, Holm Uhlig, Sten Eirik W. Jacobsen, Anna Katharina Simon Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation published pages: 466-480.e5, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2017.08.005 |
Immunity 47/3 | 2019-07-05 |
| 2017 |
Ilenia Papa, David Saliba, Maurilio Ponzoni, Sonia Bustamante, Pablo F. Canete, Paula Gonzalez-Figueroa, Hayley A. McNamara, Salvatore Valvo, Michele Grimbaldeston, Rebecca A. Sweet, Harpreet Vohra, Ian A. Cockburn, Michael Meyer-Hermann, Michael L. Dustin, Claudio Doglioni, Carola G. Vinuesa TFH-derived dopamine accelerates productive synapses in germinal centres published pages: 318-323, ISSN: 0028-0836, DOI: 10.1038/nature23013 |
Nature 547/7663 | 2019-07-05 |
| 2016 |
Viveka Mayya, Michael L. Dustin What Scales the T Cell Response? published pages: 513-522, ISSN: 1471-4906, DOI: 10.1016/j.it.2016.06.005 |
Trends in Immunology 37/8 | 2019-07-05 |
| 2018 |
Viveka Mayya, Edward Judokusumo, Enas Abu Shah, Christopher G. Peel, Willie Neiswanger, David Depoil, David A. Blair, Chris H. Wiggins, Lance C. Kam, Michael L. Dustin Durable Interactions of T Cells with T Cell Receptor Stimuli in the Absence of a Stable Immunological Synapse published pages: 340-349, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2017.12.052 |
Cell Reports 22/2 | 2019-07-05 |
| 2018 |
Ryan H. Newton, Sharad Shrestha, Jenna M. Sullivan, Kathleen B. Yates, Ewoud B. Compeer, Noga Ron-Harel, Bruce R. Blazar, Steven J. Bensinger, W. Nicholas Haining, Michael L. Dustin, Daniel J. Campbell, Hongbo Chi, Laurence A. Turka Maintenance of CD4 T cell fitness through regulation of Foxo1 published pages: 838-848, ISSN: 1529-2908, DOI: 10.1038/s41590-018-0157-4 |
Nature Immunology 19/8 | 2019-05-04 |
| 2018 |
Stefan Balint
Michael Dustin ISEV2018 abstract book published pages: 1461450, ISSN: 2001-3078, DOI: 10.1080/20013078.2018.1461450 |
Journal of Extracellular Vesicles 7/sup1 | 2019-05-04 |
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