INSOMNIA SIGNED
Insomnia’s Negative Sequelae On Mood: from Neuroscience to Intervention in the Aged
Total Cost €
0EC-Contrib. €
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Project "INSOMNIA" data sheet
The following table provides information about the project.
| Coordinator |
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
Organization address contact info |
| Coordinator Country | Netherlands [NL] |
| Total cost | 1˙867˙360 € |
| EC max contribution | 1˙867˙360 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2014-ADG |
| Funding Scheme | ERC-ADG |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-11-01 to 2020-10-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW | NL (AMSTERDAM) | coordinator | 1˙867˙360.00 |
Map
Project objective
Major depression is among the most burdening health hazards. Its prevalence is 1-3%, an additional 8-16% have clinically significant symptoms, and prognosis is poor. Unfortunately, less than 20% of the cases are detected and treatment effectiveness is moderate. The Global Consortium for Depression Prevention stresses that our best chance to combat the global burden of depression is provide preventive intervention to identified people at risk. This project targets the strongest modifiable risk factor: insomnia. With prevalence estimates up to 40%, insomnia is among the most frequent disorders in the elderly population. Meta-analysis shows that no less than 13% of people with insomnia develop depression. This extreme risk and the very high prevalence of insomnia in the ageing population, shows the urgency and promise of: (1) early identification of these 13%, (2) finding mechanisms by quantification of how they differ from insomniacs that do not develop depression with respect to brain structure and function, psychological traits, behavioural habits and environmental exposures; and (3) enrolling them in intervention protocols aimed at sleep improvement and prevention of depression. The project extends recent findings emerging from the applicant’s pioneering, unconventional and innovative approach to insomnia; the proposal that distinct subtypes exist and can be discriminated data-driven by means of multivariate trait analysis and brain imaging. Ignorance of this heterogeneity has obstructed progress in mechanistic understanding and rational treatment. In an unprecedented interdisciplinary way the project (1) identifies the insomnia subtype that develops depression; (2) profiles mechanisms involved; and (3) optimizes effectiveness of internet-supported home-applicable interventions to improve sleep and prevent depression. This approach will identify risks and mechanisms, and facilitate immediate implementation of risk-based prevention strategies and policies.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Yishul Wei, Jeanne Leerssen, Rick Wassing, Diederick Stoffers, Joy Perrier, Eus J. W. Van Someren Reduced dynamic functional connectivity between salience and executive brain networks in insomnia disorder published pages: , ISSN: 0962-1105, DOI: 10.1111/jsr.12953 |
Journal of Sleep Research | 2020-01-29 |
| 2019 |
Bart H. W. Lindert, Tessa F. Blanken, Wisse P. Meijden, Kim Dekker, Rick Wassing, Ysbrand D. Werf, Jennifer R. Ramautar, Eus J. W. Van Someren Actigraphic multiâ€night homeâ€recorded sleep estimates reveal three types of sleep misperception in Insomnia Disorder and good sleepers published pages: , ISSN: 0962-1105, DOI: 10.1111/jsr.12937 |
Journal of Sleep Research | 2020-01-29 |
| 2019 |
Tessa F Blanken, Denny Borsboom, Brenda Wjh Penninx, Eus Jw Van Someren Network outcome analysis identifies difficulty initiating sleep as a primary target for prevention of depression: a 6-year prospective study published pages: , ISSN: 0161-8105, DOI: 10.1093/sleep/zsz288 |
Sleep | 2020-01-29 |
| 2020 |
Yishul Wei, Eus JW Van Someren Interoception relates to sleep and sleep disorders published pages: 1-7, ISSN: 2352-1546, DOI: 10.1016/j.cobeha.2019.11.008 |
Current Opinion in Behavioral Sciences 33 | 2020-01-29 |
| 2019 |
Shadi Bagherzadeh-Azbari, Habibolah Khazaie, Mojtaba Zarei, Kai Spiegelhalder, Martin Walter, Jeanne Leerssen, Eus J.W. Van Someren, Amir A. Sepehry, Masoud Tahmasian Neuroimaging insights into the link between depression and Insomnia: A systematic review published pages: 133-143, ISSN: 0165-0327, DOI: 10.1016/j.jad.2019.07.089 |
Journal of Affective Disorders 258 | 2020-01-29 |
| 2019 |
Yishul Wei, Tom Bresser, Rick Wassing, Diederick Stoffers, Eus J.W. Van Someren, Jessica C. Foster-Dingley Brain structural connectivity network alterations in insomnia disorder reveal a central role of the right angular gyrus published pages: 102019, ISSN: 2213-1582, DOI: 10.1016/j.nicl.2019.102019 |
NeuroImage: Clinical 24 | 2020-01-29 |
| 2019 |
Rick Wassing, Frans Schalkwijk, Oti Lakbila-Kamal, Jennifer R Ramautar, Diederick Stoffers, Henri J M M Mutsaerts, Lucia M Talamini, Eus J W Van Someren Haunted by the past: old emotions remain salient in insomnia disorder published pages: 1783-1796, ISSN: 0006-8950, DOI: 10.1093/brain/awz089 |
Brain 142/6 | 2019-08-30 |
| 2019 |
Jacob Itzhacki, Bart H. W. te Lindert, Wisse P. van der Meijden, Morten L. Kringelbach, Jorge Mendoza, Eus J. W. Van Someren Environmental light and time of day modulate subjective liking and wanting. published pages: 10-20, ISSN: 1528-3542, DOI: 10.1037/emo0000402 |
Emotion 19/1 | 2019-08-30 |
| 2019 |
Rick Wassing, Oti Lakbila-Kamal, Jennifer R. Ramautar, Diederick Stoffers, Frans Schalkwijk, Eus J.W. Van Someren Restless REM Sleep Impedes Overnight Amygdala Adaptation published pages: 2351-2358.e4, ISSN: 0960-9822, DOI: 10.1016/j.cub.2019.06.034 |
Current Biology 29/14 | 2019-08-30 |
| 2018 |
Masoud Tahmasian, Khadijeh Noori, Fateme Samea, Mojtaba Zarei, Kai Spiegelhalder, Simon B. Eickhoff, Eus Van Someren, Habibolah Khazaie, Claudia R. Eickhoff A lack of consistent brain alterations in insomnia disorder: An activation likelihood estimation meta-analysis published pages: 111-118, ISSN: 1087-0792, DOI: 10.1016/j.smrv.2018.07.004 |
Sleep Medicine Reviews 42 | 2019-08-30 |
| 2019 |
Frans Schalkwijk, Eus J.W. Van Someren, Rick Wassing A clinical interpretation of shame regulation in maladaptive perfectionism published pages: 19-23, ISSN: 0191-8869, DOI: 10.1016/j.paid.2018.09.001 |
Personality and Individual Differences 138 | 2019-08-30 |
| 2019 |
Jeanne Leerssen, Rick Wassing, Jennifer R. Ramautar, Diederick Stoffers, Oti Lakbila-Kamal, Joy Perrier, Jessica Bruijel, Jessica C. Foster-Dingley, Moji Aghajani, Eus J.W. van Someren Increased hippocampal-prefrontal functional connectivity in insomnia published pages: 144-150, ISSN: 1074-7427, DOI: 10.1016/j.nlm.2018.02.006 |
Neurobiology of Learning and Memory 160 | 2019-08-30 |
| 2019 |
Philip R. Jansen, Kyoko Watanabe, Sven Stringer, Nathan Skene, Julien Bryois, Anke R. Hammerschlag, Christiaan A. de Leeuw, Jeroen S. Benjamins, Ana B. Muñoz-Manchado, Mats Nagel, Jeanne E. Savage, Henning Tiemeier, Tonya White, Joyce Y. Tung, David A. Hinds, Vladimir Vacic, Xin Wang, Patrick F. Sullivan, Sophie van der Sluis, Tinca J. C. Polderman, August B. Smit, Jens Hjerling-Leffler, Eus J. W Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways published pages: 394-403, ISSN: 1061-4036, DOI: 10.1038/s41588-018-0333-3 |
Nature Genetics 51/3 | 2019-08-30 |
| 2018 |
Jacob Itzhacki, Daniel Clesse, Yannick Goumon, Eus J. Van Someren, Jorge Mendoza Light rescues circadian behavior and brain dopamine abnormalities in diurnal rodents exposed to a winter-like photoperiod published pages: 2641-2652, ISSN: 1863-2653, DOI: 10.1007/s00429-018-1655-8 |
Brain Structure and Function 223/6 | 2019-08-30 |
| 2018 |
Bart H W te Lindert, Jacob Itzhacki, Wisse P van der Meijden, Morten L Kringelbach, Jorge Mendoza, Eus J W Van Someren Bright environmental light ameliorates deficient subjective ‘liking’ in insomnia: an experience sampling study published pages: zsy022, ISSN: 0161-8105, DOI: 10.1093/sleep/zsy022 |
Sleep 41/4 | 2019-08-30 |
| 2018 |
Masoud Tahmasian, Mojtaba Zarei, Khadijeh Noori, Habibolah Khazaie, Fateme Samea, Kai Spiegelhalder, Simon B. Eickhoff, Eus Van Someren, Claudia R. Eickhoff Reply to Hua Liu, HaiCun Shi and PingLei Pan: Coordinate based meta-analyses in a medium sized literature: Considerations, limitations and road ahead published pages: 236-238, ISSN: 1087-0792, DOI: 10.1016/j.smrv.2018.08.004 |
Sleep Medicine Reviews 42 | 2019-08-30 |
| 2018 |
Rick Wassing, Jeroen S Benjamins, Lucia M Talamini, Frans Schalkwijk, Eus J W Van Someren Overnight worsening of emotional distress indicates maladaptive sleep in insomnia published pages: zsy268, ISSN: 0161-8105, DOI: 10.1093/sleep/zsy268 |
Sleep 42/4 | 2019-08-30 |
| 2015 |
E. J. W. Van Someren, C. Cirelli, D.-J. Dijk, E. Van Cauter, S. Schwartz, M. W. L. Chee Disrupted Sleep: From Molecules to Cognition published pages: 13889-13895, ISSN: 0270-6474, DOI: 10.1523/JNEUROSCI.2592-15.2015 |
Journal of Neuroscience 35/41 | 2019-07-08 |
| 2016 |
Jeroen S. Benjamins, Filippo Migliorati, Kim Dekker, Rick Wassing, Sarah Moens, Tessa F. Blanken, Bart H.W. te Lindert, Jeffrey Sjauw Mook, Eus J.W. Van Someren Insomnia heterogeneity: characteristics to consider for data-driven multivariate subtyping published pages: , ISSN: 1087-0792, DOI: 10.1016/j.smrv.2016.10.005 |
Sleep Medicine Reviews | 2019-07-08 |
| 2016 |
B. Alexander Diaz, Richard Hardstone, Huibert D. Mansvelder, Eus J. W. Van Someren, Klaus Linkenkaer-Hansen Resting-State Subjective Experience and EEG Biomarkers Are Associated with Sleep-Onset Latency published pages: 492, ISSN: 1664-1078, DOI: 10.3389/fpsyg.2016.00492 |
Frontiers in Psychology 7 | 2019-07-08 |
| 2016 |
Tanja van der Zweerde, Jaap Lancee, Pauline Slottje, Judith Bosmans, Eus Van Someren, Charles Reynolds, Pim Cuijpers, Annemieke van Straten Cost-effectiveness of i-Sleep, a guided online CBT intervention, for patients with insomnia in general practice: protocol of a pragmatic randomized controlled trial published pages: 85, ISSN: 1471-244X, DOI: 10.1186/s12888-016-0783-z |
BMC Psychiatry 16/1 | 2019-07-08 |
| 2017 |
Giovanni Piantoni, Nico Romeijn, German Gomez-Herrero, Ysbrand D. Van Der Werf, Eus J. W. Van Someren Alpha Power Predicts Persistence of Bistable Perception published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-05610-8 |
Scientific Reports 7/1 | 2019-07-08 |
| 2016 |
Michele A. Colombo, Yishul Wei, Jennifer R. Ramautar, Klaus Linkenkaer-Hansen, Enzo Tagliazucchi, Eus J. W. Van Someren More Severe Insomnia Complaints in People with Stronger Long-Range Temporal Correlations in Wake Resting-State EEG published pages: 576, ISSN: 1664-042X, DOI: 10.3389/fphys.2016.00576 |
Frontiers in Physiology 7 | 2019-07-08 |
| 2016 |
Yishul Wei, Jennifer R. Ramautar, Michele A. Colombo, Diederick Stoffers, Germ?n G?mez-Herrero, Wisse P. van der Meijden, Bart H.W. te Lindert, Ysbrand D. van der Werf, Eus J.W. Van Someren I Keep a Close Watch on This Heart of Mine: Increased Interoception in Insomnia published pages: 2113-2124, ISSN: 0161-8105, DOI: 10.5665/sleep.6308 |
SLEEP 39/12 | 2019-07-08 |
| 2016 |
Rick Wassing, Jeroen S. Benjamins, Kim Dekker, Sarah Moens, Kai Spiegelhalder, Bernd Feige, Dieter Riemann, Sophie van der Sluis, Ysbrand D. Van Der Werf, Lucia M. Talamini, Matthew P. Walker, Frans Schalkwijk, Eus J. W. Van Someren Slow dissolving of emotional distress contributes to hyperarousal published pages: 2538-2543, ISSN: 0027-8424, DOI: 10.1073/pnas.1522520113 |
Proceedings of the National Academy of Sciences 113/9 | 2019-07-08 |
| 2017 |
Kim Dekker, Tessa Blanken, Eus Van Someren Insomnia and Personality—A Network Approach published pages: 28, ISSN: 2076-3425, DOI: 10.3390/brainsci7030028 |
Brain Sciences 7/3 | 2019-07-08 |
| 2017 |
Anke R Hammerschlag, Sven Stringer, Christiaan A de Leeuw, Suzanne Sniekers, Erdogan Taskesen, Kyoko Watanabe, Tessa F Blanken, Kim Dekker, Bart H W te Lindert, Rick Wassing, Ingileif Jonsdottir, Gudmar Thorleifsson, Hreinn Stefansson, Thorarinn Gislason, Klaus Berger, Barbara Schormair, Juergen Wellmann, Juliane Winkelmann, Kari Stefansson, Konrad Oexle, Eus J W Van Someren, Danielle Posthuma Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits published pages: , ISSN: 1061-4036, DOI: 10.1038/ng.3888 |
Nature Genetics | 2019-07-08 |
| 2015 |
Eus J. W. Van Someren, Kim Dekker, Bart H. W. Te Lindert, Jeroen S. Benjamins, Sarah Moens, Filippo Migliorati, Emmeke Aarts, Sophie van der Sluis The experienced temperature sensitivity and regulation survey published pages: 59-76, ISSN: 2332-8940, DOI: 10.1080/23328940.2015.1130519 |
Temperature 3/1 | 2019-07-08 |
| 2016 |
Michele A. Colombo, Jennifer R. Ramautar, Yishul Wei, Germán Gomez-Herrero, Diederick Stoffers, Rick Wassing, Jeroen S. Benjamins, Enzo Tagliazucchi, Ysbrand D. van der Werf, Christian Cajochen, Eus J.W. Van Someren Wake High-Density Electroencephalographic Spatiospectral Signatures of Insomnia published pages: 1015-1027, ISSN: 0161-8105, DOI: 10.5665/sleep.5744 |
SLEEP 39/05 | 2019-07-08 |
| 2019 |
Tessa F Blanken, Jeroen S Benjamins, Denny Borsboom, Jeroen K Vermunt, Casey Paquola, Jennifer Ramautar, Kim Dekker, Diederick Stoffers, Rick Wassing, Yishul Wei, Eus J W Van Someren Insomnia disorder subtypes derived from life history and traits of affect and personality published pages: 151-163, ISSN: 2215-0366, DOI: 10.1016/s2215-0366(18)30464-4 |
The Lancet Psychiatry 6/2 | 2019-08-30 |
| 2019 |
Tessa F. Blanken, Tanja Van Der Zweerde, Annemieke Van Straten, Eus J.W. Van Someren, Denny Borsboom, Jaap Lancee Introducing Network Intervention Analysis to Investigate Sequential, Symptom-Specific Treatment Effects: A Demonstration in Co-Occurring Insomnia and Depression published pages: 52-54, ISSN: 0033-3190, DOI: 10.1159/000495045 |
Psychotherapy and Psychosomatics 88/1 | 2019-08-30 |
| 2019 |
Tessa F Blanken, Eus J W van Someren Subtyping insomnia disorder – Authors\' reply published pages: 285-286, ISSN: 2215-0366, DOI: 10.1016/s2215-0366(19)30079-3 |
The Lancet Psychiatry 6/4 | 2019-08-30 |
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