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Opendata, web and dolomites

BOOSTB4 SIGNED

Boost Brittle Bones Before Birth

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

BOOSTB4 project word cloud

Explore the words cloud of the BOOSTB4 project. It provides you a very rough idea of what is the project "BOOSTB4" about.

outcomes forms conduct mineral characterised mesenchymal secondary prenatal quality devastating patient validated rejection additional handicap clinical transplantation demonstrated onset density lifetime osteogenesis multiple frequency karolinska receive centres treatment life granted disease bones boostb4 requests imperfecta international birth cells fracture msc severe curative stem fractures engraftment initial ki institutet inherited underway confirm successful outcome regular principal experts made ethical postnatal invasive physicians molecular oi therapy undergo relate efficacy multicentre considerable inclusion disorder fetal facilitated repeated regulatory led approvals safety brittle trial pain severest diagnosis bone preclinical patients defects excellence person primary

Project "BOOSTB4" data sheet

The following table provides information about the project.

Coordinator	KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Sweden [SE]
Project website	http://boostb4.eu/
Total cost	8˙378˙755 €
EC max contribution	6˙608˙754 € (79%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-PHC-2015-single-stage_RTD
Funding Scheme	RIA
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2020-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	coordinator	1˙827˙061.00
2	GREAT ORMOND STREET HOSPITAL FOR CHILDREN NHS FOUNDATION TRUST GREAT ORMOND STREET HOSPITAL FOR CHILDREN NHS FOUNDATION TRUST Organization address address: GREAT ORMOND STREET city: LONDON postcode: WC1N 3JH website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	1˙410˙493.00
3	KLINIKUM DER UNIVERSITAET ZU KOELN KLINIKUM DER UNIVERSITAET ZU KOELN Organization address address: Kerpener Strasse 62 city: KOELN postcode: 50937 website: www.uk-koeln.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (KOELN)	participant	703˙132.00
4	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	648˙543.00
5	CELLPROTECT NORDIC PHARMACEUTICALS AB CELLPROTECT NORDIC PHARMACEUTICALS AB Organization address address: Haelsovaegen 7 city: Huddinge postcode: 141 57 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (Huddinge)	participant	549˙781.00
6	ACADEMISCH ZIEKENHUIS LEIDEN ACADEMISCH ZIEKENHUIS LEIDEN Organization address address: ALBINUSDREEF 2 city: LEIDEN postcode: 2333 ZA website: www.lumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	408˙395.00
7	UNIVERSITAIR MEDISCH CENTRUM UTRECHT UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	participant	262˙097.00
8	LUNDS UNIVERSITET LUNDS UNIVERSITET Organization address address: Paradisgatan 5c city: LUND postcode: 22100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (LUND)	participant	241˙156.00
9	A2F ASSOCIATES LIMITED A2F ASSOCIATES LIMITED Organization address address: 7 LAUREATE PADDOCKS city: NEWMARKET postcode: CB8 0AP website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (NEWMARKET)	participant	203˙725.00
10	MEDSCINET AB MEDSCINET AB Organization address address: Luntmakargatan 71 city: Stockholm postcode: 11351 website: www.medscinet.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (Stockholm)	participant	121˙093.00
11	NORDIC HEALTH ECONOMICS AB NORDIC HEALTH ECONOMICS AB Organization address address: MEDICINAREGATAN 8B city: GOTEBORG postcode: 413 46 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (GOTEBORG)	participant	106˙000.00
12	EURAM LIMITED EURAM LIMITED Organization address address: LUCY TOWER STREET TOWER HOUSE city: LINCOLN postcode: LN1 1XW website: www.euram.ltd.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LINCOLN)	participant	77˙275.00
13	UNIVERSITY OF LEICESTER UNIVERSITY OF LEICESTER Organization address address: UNIVERSITY ROAD city: LEICESTER postcode: LE1 7RH website: www.le.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LEICESTER)	participant	50˙000.00

Map

Project objective

Osteogenesis imperfecta (OI) is, in its severe forms, a devastating inherited disorder characterised by brittle bones. A person with severe OI is affected throughout their lifetime with repeated, multiple fractures, considerable pain and handicap. There is no curative or effective treatment for OI. Our preclinical studies and initial clinical cases have demonstrated that transplantation of fetal mesenchymal stem cells (MSC) is a promising approach for treatment of OI. We receive regular requests for MSC transplantation from patients and their physicians; patient organisations support our approach. The principal objective of the BOOSTB4 project is to conduct a Phase I/II clinical trial of the safety and efficacy of pre- and/or postnatal MSC transplantation in the severest forms of OI (type III, severe type IV). Transplantation before birth at the onset of disease should lead to greater efficacy and engraftment with less rejection than transplantation after birth. Postnatal transplantation will be evaluated in cases where prenatal diagnosis was not made. The trial’s primary outcome is safety; secondary outcomes relate to efficacy (fracture frequency, growth, bone mineral density and quality of life). All patients will undergo molecular diagnosis to confirm OI before inclusion in the trial. Non-invasive prenatal diagnosis will be developed and validated. The BOOSTB4 consortium is led by experts in MSC, prenatal therapy and OI at the Karolinska Institutet (KI), which will also lead the international multicentre trial; five additional EU centres of excellence are included. Ethical and regulatory applications are underway to conduct this clinical trial. These are facilitated by the ethical and regulatory approvals for prenatal MSC transplantation in 10 cases of OI that have already been granted at KI. Successful prenatal transplantation represents a major step forward in the management of patients with severe OI, and beyond, to a range of other inherited birth defects.

Deliverables

List of deliverables.
Project website	Websites, patent fillings, videos etc.	2020-04-14 21:13:20

Take a look to the deliverables list in detail: detailed list of BOOSTB4 deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2016	Jennifer Couzin-Frankel Ailing fetuses to be treated with stem cells published pages: , ISSN: 0036-8075, DOI: 10.1126/science.aaf9912	Science	2020-04-14
2016	www.horizon2020projects.com Boosting bones published pages: 166-167, ISSN: 2054-2631, DOI:	Horizon 2020 Projects: Portal January 2016, Quarterly	2020-04-14
2018	Natalie Chandler, Sunayna Best, Jane Hayward, Francesca Faravelli, Sahar Mansour, Emma Kivuva, Dagmar Tapon, Alison Male, Catherine DeVile, Lyn S Chitty Rapid prenatal diagnosis using targeted exome sequencing: a cohort study to assess feasibility and potential impact on prenatal counseling and pregnancy management published pages: 1430-1437, ISSN: 1098-3600, DOI: 10.1038/gim.2018.30	Genetics in Medicine 20/11	2020-04-14
2018	Melissa Hill, Celine Lewis, Megan Riddington, Belinda Crowe, Catherine DeVile, Cecilia GÃ¶therstrÃ¶m, Lyn Chitty Exploring the impact of Osteogenesis Imperfecta on families: A mixed-methods systematic review published pages: , ISSN: 1936-6574, DOI: 10.1016/j.dhjo.2018.12.003	Disability and Health Journal	2020-04-14
2017	Jane Hayward, Lyn Chitty, Lucy Jenkins, Fiona McKay, Natalie Chandler, Helena Ahlfors and Sunayna Best Oral Abstracts of the ISPD 21 st International Conference on Prenatal Diagnosis and Therapy, San Diego, California, USA, 9-12 July 2017 published pages: 3-20, ISSN: 0197-3851, DOI: 10.1002/pd.5084	Prenatal Diagnosis 37	2020-04-14
2019	Mats Johansson, GÃ¶ran HermerÃ©n, Nils-Eric Sahlin Paternal consent in prenatal research: ethical aspects published pages: , ISSN: 1386-7423, DOI: 10.1007/s11019-019-09919-1	Medicine, Health Care and Philosophy	2020-04-14

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