HoloVision TERMINATED
Advanced holographic optical neural stimulation for vision restoration and basic research
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0HoloVision project word cloud
Explore the words cloud of the HoloVision project. It provides you a very rough idea of what is the project "HoloVision" about.
Project "HoloVision" data sheet
The following table provides information about the project.
| Coordinator |
TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Organization address contact info |
| Coordinator Country | Israel [IL] |
| Project website | https://niel.net.technion.ac.il/ |
| Total cost | 2˙624˙517 € |
| EC max contribution | 2˙624˙517 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2014-CoG |
| Funding Scheme | ERC-COG |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-01-01 to 2020-12-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY | IL (HAIFA) | coordinator | 2˙624˙517.00 |
Map
Project objective
When natural sensory input is disrupted, as in outer-retinal degenerative diseases, artificial stimulation of surviving nerve cells offers a potential strategy for bypassing compromised neural circuits and substituting sensory perception. Current neuro-stimulation interfaces that use electrical currents from micro-electrode arrays are already being clinically applied for retinal stimulation, but their performance is ultimately limited by current spread and the requirement for physical contact with an implanted device. Future minimally-invasive systems could use light patterns to photo-induce complex yet precise spatio-temporal activity patterns among surviving retinal neurons, with the ultimate potential of restoring vision to a nearly normal level. Here, we will advance, optimize and test in vivo a powerful new strategy for cellular-resolution controlled patterned optogenetic excitation, based on computer-generated holographic optical neural-stimulation (HONS). Regular (one-photon) HONS systems can dynamically address large populations of optogenetically-transduced retinal ganglion cells with single-cell resolution, while related multiphoton HONS systems can extend these capabilities to three-dimensional cortical tissue (relevant to many research applications). A series of in vivo experiments will resolve basic questions regarding the efficacy of these approaches by directly examining the retinal and cortical responses to structured holographic photo-stimulation, and test novel strategies for improving it. Finally, as a major step towards clinical translation of this technology, we will design and evaluate (in blind sheep and sighted individuals) a human-scale prototype. Overall, by combining both basic and translational research, this study will advance novel optical neuro-technologies with potential impact on multiple scientific and clinical applications. Specifically, it will tackle the major engineering requirements and constraints towards the development of a
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2017 |
Ronald W. Boutte, Sam Merlin, Guy Yona, Brandon Griffiths, Alessandra Angelucci, Itamar Kahn, Shy Shoham, Steve Blair Utah optrode array customization using stereotactic brain atlases and 3-D CAD modeling for optogenetic neocortical interrogation in small rodents and nonhuman primates published pages: 41502, ISSN: 2329-423X, DOI: 10.1117/1.NPh.4.4.041502 |
Neurophotonics 4/4 | 2019-06-07 |
| 2018 |
Tal Aharoni, Shy Shoham Phase-controlled, speckle-free holographic projection with applications in precision optogenetics published pages: 1, ISSN: 2329-423X, DOI: 10.1117/1.NPh.5.2.025004 |
Neurophotonics 5/02 | 2019-06-07 |
| 2017 |
Anat Marom, Erez Shor, Shulamit Levenberg, Shy Shoham Spontaneous Activity Characteristics of 3D “Optonets†published pages: Article 602, ISSN: 1662-453X, DOI: 10.3389/fnins.2016.00602 |
Frontiers in Neuroscience 10 | 2019-06-07 |
| 2017 |
Michael Plaksin, Eitan Kimmel and Shy Shoham Thermal transients excite neurons through universalintramembrane mechano-electrical effects published pages: , ISSN: , DOI: 10.1101/111724 |
biorxiv | 2019-06-07 |
| 2017 |
Michael Plaksin, Eitan Kimmel, Shy Shoham Correspondence: Revisiting the theoretical cell membrane thermal capacitance response published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-00435-5 |
Nature Communications 8/1 | 2019-06-07 |
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "HOLOVISION" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "HOLOVISION" are provided by the European Opendata Portal: CORDIS opendata.