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MIB SIGNED

Multi-modal, Endoscopic Biophotonic Imaging of Bladder Cancer for Point-of-Care Diagnosis

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

MIB project word cloud

Explore the words cloud of the MIB project. It provides you a very rough idea of what is the project "MIB" about.

opto quality sources raman bladder acoustic commercialization imaging rates multiphoton drastically biochemical equally 10 optical speed hypothesis microscopy hospitalisation point fibre spectral anatomic shifted industry relies treatment unmet expensive specificity coherence medical capture partnership reinforce biomedical difference earlier follow combination combining excitation spectroscopy savings clinically recurrence innovative light world patient bundles molecular endoscopically diagnosis academic clinical cancer prognosis procedure tissue platform life positions oncology time unprecedented sensitivity reducing situ superior onset vivo care 360m invasive hybrid combined tomography endoscopes functional smes structural diagnostics diseases diagnostic days mib market healthcare

Project "MIB" data sheet

The following table provides information about the project.

Coordinator	DANMARKS TEKNISKE UNIVERSITET Organization address address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A city: KGS LYNGBY postcode: 2800 website: www.dtu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Denmark [DK]
Project website	http://mib-h2020.eu
Total cost	5˙983˙807 €
EC max contribution	5˙983˙807 € (100%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-PHC-2015-two-stage
Funding Scheme	RIA
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2020-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	DANMARKS TEKNISKE UNIVERSITET DANMARKS TEKNISKE UNIVERSITET Organization address address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A city: KGS LYNGBY postcode: 2800 website: www.dtu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KGS LYNGBY)	coordinator	829˙254.00
2	MEDIZINISCHE UNIVERSITAET WIEN MEDIZINISCHE UNIVERSITAET WIEN Organization address address: SPITALGASSE 23 city: WIEN postcode: 1090 website: www.meduniwien.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	689˙078.00
3	FORSCHUNGSVERBUND BERLIN EV FORSCHUNGSVERBUND BERLIN EV Organization address address: RUDOWER CHAUSSEE 17 city: BERLIN postcode: 12489 website: www.fv-berlin.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	participant	669˙582.00
4	HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH Organization address address: INGOLSTADTER LANDSTRASSE 1 city: NEUHERBERG postcode: 85764 website: www.helmholtz-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (NEUHERBERG)	participant	655˙046.00
5	LEIBNIZ-INSTITUT FUER PHOTONISCHE TECHNOLOGIEN E.V. LEIBNIZ-INSTITUT FUER PHOTONISCHE TECHNOLOGIEN E.V. Organization address address: Albert Einstein strasse 9 city: JENA postcode: 7745 website: www.ipht-jena.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (JENA)	participant	653˙875.00
6	M-SQUARED LASERS LIMITED M-SQUARED LASERS LIMITED Organization address address: VENTURE BUILDING 1 KELVIN CAMPUS MARYHILL ROAD WEST OF SCOTLAND SCIENCE PARK city: GLASGOW postcode: G20 0SP website: www.m2lasers.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (GLASGOW)	participant	512˙500.00
7	2M ENGINEERING LIMITED 2M ENGINEERING LIMITED Organization address address: SIDNEY STREET 80 city: FOLKSTONE postcode: CT19 6HQ website: www.2mel.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (FOLKSTONE)	participant	502˙102.00
8	REGION HOVEDSTADEN REGION HOVEDSTADEN Organization address address: KONGENS VAENGE 2 city: HILLEROD postcode: 3400 website: www.regionh.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (HILLEROD)	participant	479˙081.00
9	Blazejewski MEDI-TECH GMBH Blazejewski MEDI-TECH GMBH Organization address address: Elzstrasse 2 city: Sexau postcode: 79350 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Sexau)	participant	432˙812.00
10	GRINTECH GMBH GRINTECH GMBH Organization address address: SCHILLERSTRASSE 1 city: Jena postcode: 7745 website: www.grintech.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Jena)	participant	365˙475.00
11	ALBERT-LUDWIGS-UNIVERSITAET FREIBURG ALBERT-LUDWIGS-UNIVERSITAET FREIBURG Organization address address: FAHNENBERGPLATZ city: FREIBURG postcode: 79098 website: www.uni-freiburg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (FREIBURG)	participant	195˙000.00

Map

Project objective

Bladder cancer is among the most expensive diseases in oncology in terms of treatment costs; each procedure requires days of hospitalisation and recurrence rates are high. Current unmet clinical needs can be addressed by optical methods due to the combination of non-invasive and real-time capture of unprecedented biomedical information. The MIB objective is to provide robust, easy-to-use, cost-effective optical methods with superior sensitivity and specificity to enable a step-change in point-of-care diagnostics of bladder cancer. The concept relies on combining optical methods (optical coherence tomography, multi-spectral opto-acoustic tomography, shifted excitation Raman difference spectroscopy, and multiphoton microscopy) providing structural, biochemical and functional information. The hypothesis is that such combination enables in situ diagnosis of bladder cancer with superior sensitivity and specificity due to unprecedented combined anatomic, biochemical and molecular tissue information. The step-change is that this hybrid concept is provided endoscopically for in vivo clinical use. The project relies on development of new light sources, high-speed imaging systems, unique imaging fibre bundles, and endoscopes, combined and applied clinically. The consortium comprises world-leading academic organisations in a strong partnership with innovative SMEs and clinical end-users. Through commercialization of this novel imaging platform, MIB is expected to reinforce leading market positions in medical devices and healthcare for the SMEs in areas where European industry is already strong. The impact is that improved diagnostic procedures facilitate earlier onset of effective treatment, thus recurrence and follow-up procedures would be reduced by 10%, i.e., reducing costs. Using MIB technology, healthcare cost savings in the order of 360M€ are expected for the whole EU. Equally important, prognosis and patient quality of life would improve drastically.

Deliverables

List of deliverables.
Project Website	Demonstrators, pilots, prototypes	2020-04-07 20:27:06

Take a look to the deliverables list in detail: detailed list of MIB deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2020	Fabian Placzek, Eliana Cordero Bautista, Simon Kretschmer, Lara M. Wurster, Florian Knorr, Gerardo GonzÃ¡lez-Cerdas, Mikael T. ErkkilÃ¤, Patrick Stein, Ã‡aÄŸlar Ataman, Gregers G. Hermann, Karin Mogensen, Thomas Hasselager, Peter E. Andersen, Hans Zappe, JÃ¼rgen Popp, Wolfgang Drexler, Rainer A. Leitgeb, Iwan W. Schie Morpho-molecular ex vivo detection and grading of non-muscle-invasive bladder cancer using forward imaging probe based multimodal optical coherence tomography and Raman spectroscopy published pages: , ISSN: 0003-2654, DOI: 10.1039/c9an01911a	The Analyst	2020-04-07
2018	Martin Maiwald, Bernd Sumpf, GÃ¼nther TrÃ¤nkle Rapid and adjustable shifted excitation Raman difference spectroscopy using a dual-wavelength diode laser at 785Â nm published pages: , ISSN: 0377-0486, DOI: 10.1002/jrs.5456	Journal of Raman Spectroscopy	2020-04-07
2018	Daniela Bovenkamp, Ryan Sentosa, Elisabet Rank, Mikael ErkkilÃ¤, Fabian Placzek, Jeremias PÃ¼ls, Wolfgang Drexler, Rainer Leitgeb, Nathalie Garstka, Shahrokh Shariat, Clara Stiebing, Iwan Schie, JÃ¼rgen Popp, Marco Andreana, Angelika Unterhuber Combination of High-Resolution Optical Coherence Tomography and Raman Spectroscopy for Improved Staging and Grading in Bladder Cancer published pages: 2371, ISSN: 2076-3417, DOI: 10.3390/app8122371	Applied Sciences 8/12	2020-04-07
2018	Dominik Marti, Rikke N. Aasbjerg, Peter E. Andersen, Anders K. Hansen MCmatlab: an open-source, user-friendly, MATLAB-integrated three-dimensional Monte Carlo light transport solver with heat diffusion and tissue damage published pages: 1, ISSN: 1083-3668, DOI: 10.1117/1.jbo.23.12.121622	Journal of Biomedical Optics 23/12	2020-04-07
2019	Lara M. Wurster, Ronak N. Shah, Fabian Placzek, Simon Kretschmer, Michael Niederleithner, Laurin Ginner, Jason Ensher, Michael P. Minneman, Erich E. Hoover, Hans Zappe, Wolfgang Drexler, Rainer A. Leitgeb, Ã‡aÄŸlar Ataman Endoscopic optical coherence tomography angiography using a forward imaging piezo scanner probe published pages: e201800382, ISSN: 1864-063X, DOI: 10.1002/jbio.201800382	Journal of Biophotonics	2020-04-07
2018	Eliana Cordero In-vivo Raman spectroscopy: from basics to applications published pages: 1, ISSN: 1083-3668, DOI: 10.1117/1.jbo.23.7.071210	Journal of Biomedical Optics 23/07	2020-04-07

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