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EU4HIVCURE project deliverables

The page lists 2 deliverables related to the research project "EU4HIVCURE".

List of Deliverables

EU4HIVCURE: list of downloadable deliverables.
title and desprition	type	last update
Mode of action of MATR3, PTB, PSF and HIV reactivation; Discovery of new host factors implicated in HIV-1 RNA nuclear export and HIV-1 post-transcriptional silencing; Select drugs to be validated in WP5 Define the mode of action of MATR3, PTB, PSF on HIV RNA nuclear export. Exploiting shRNA and CRISPR/Cas9 systems we will explore MATR3 mutants and assess their behaviour by functional assays including monitoring of HIV RNA nuclear export by live imaging. Live imaging will be complemented by studies at NUID UCD. Develop an unbiased high-throughput assay for the identification of other potential post-transcriptional blocks of HIV reactivation, which include nuclear export of HIV RNA, translation and packaging. Test and select new latency-reversible compounds targeting functionally host proteins involved in post-transcriptional HIV-1 silencing using in vitro latency models. Programme: H2020-EU.1.3.3. - Topic(s): MSCA-RISE-2015 download deliverable	Documents, reports	2020-04-09
Determination of the potency, synergistic activity and toxicity of novel classes of LRA HMTI, HDACI, HDMT inhibitors, DNA methylation inhibitors, NF-Ä¸B inducers and compounds releasing active P-TEFb complex will be tested first alone and in combination in latently-infected cell lines. Analyze the effect of the HIV-1 inducers on viral reactivation in ex vivo cultures of CD8+-depleted PBMCs. We will also study the patient-specific variations in the ex vivo reactivation capacity of the HIV-infected cells in ex vivo cultures of resting CD4+ T cells. Resting (CD69- CD25- HLA-DR-) Programme: H2020-EU.1.3.3. - Topic(s): MSCA-RISE-2015 download deliverable	Documents, reports	2020-04-09