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EU4HIVCURE SIGNED

Accelerating HIV Cure in Europe

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

EU4HIVCURE project word cloud

Explore the words cloud of the EU4HIVCURE project. It provides you a very rough idea of what is the project "EU4HIVCURE" about.

cure persistence transcriptionally therapy expertise genome 35 viral universities aids exchange intersectoral dissect interdisciplinary forcing canada 21st gene global international translation networking university retroviral mechanisms latent eliminating training accelerate eu4hivcure latency continuum million druggable reservoirs clinic obstacle cellular countries hospitals competent reversing persistent brings health silenced intricate hiv century secondements maximises finding replication paramount anti immune organisation individuals expression eradication framework escape living strategies eradicate

Project "EU4HIVCURE" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN Organization address address: BELFIELD city: DUBLIN postcode: 4 website: www.ucd.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Ireland [IE]
Total cost	328˙500 €
EC max contribution	310˙500 € (95%)
Programme	1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
Code Call	H2020-MSCA-RISE-2015
Funding Scheme	MSCA-RISE
Starting year	2016
Duration (year-month-day)	from 2016-02-01 to 2020-01-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN Organization address address: BELFIELD city: DUBLIN postcode: 4 website: www.ucd.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	coordinator	108˙000.00
2	UNIVERSITE DE STRASBOURG UNIVERSITE DE STRASBOURG Organization address address: RUE BLAISE PASCAL 4 city: STRASBOURG postcode: 67081 website: http://www.unistra.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (STRASBOURG)	participant	121˙500.00
3	UNIVERSITE LIBRE DE BRUXELLES UNIVERSITE LIBRE DE BRUXELLES Organization address address: AVENUE FRANKLIN ROOSEVELT 50 city: BRUXELLES postcode: 1050 website: www.ulb.ac.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUXELLES)	participant	81˙000.00
4	ASSOCIATION HOSPITALIERE DE BRUXELLES-CENTRE HOSPITALIER UNIVERSITAIRE SAINT PIERRE ASSOCIATION HOSPITALIERE DE BRUXELLES-CENTRE HOSPITALIER UNIVERSITAIRE SAINT PIERRE Organization address address: RUE HAUTE 322 city: BRUXELLES postcode: 1000 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUXELLES)	participant	0.00
5	INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY Organization address address: PADRICIANO 99 city: TRIESTE postcode: 34149 website: www.icgeb.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (TRIESTE)	participant	0.00
6	MATER MISERICORDIAE UNIVERSITY HOSPITAL MATER MISERICORDIAE UNIVERSITY HOSPITAL Organization address address: ECCLES STREET city: DUBLIN postcode: 7 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	participant	0.00
7	UNIVERSITE DE MONTREAL UNIVERSITE DE MONTREAL Organization address address: CP 6128 Station Centre Ville city: MONTREAL postcode: H3C3J7 website: www.umontreal.ca contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CA (MONTREAL)	partner	0.00

Map

Project objective

Finding a CURE for 35 Million individuals living with HIV/AIDS is one of the great global health challenges of the 21st century. The major obstacle to HIV eradication is the persistence of latent HIV cellular reservoirs, where the integrated viral genome is transcriptionally silenced but replication-competent and can escape both Anti-Retroviral Therapy and Immune Responses. The development of novel strategies aimed at eliminating these reservoirs have become paramount in HIV research, if we want to achieve an HIV/AIDS CURE.

To accelerate the State of the Art in HIV CURE research in Europe, our EU4HIVCURE consortium brings together an intersectoral and interdisciplinary collaboration between 3 Universities, 3 Hospitals, 1 International Research Organisation from 4 European countries and 1 University from Canada. Our aim is to dissect the intricate mechanisms controlling HIV-1 latency and identify new druggable targets to develop novel latency-reversing strategies and eradicate persistent viral reservoirs by forcing HIV-1 gene expression. To facilitate continuum for translation to the clinic, we have developed an operational framework, which maximises exchange of knowledge and expertise via secondements, networking and training activities.

Deliverables

List of deliverables.
Mode of action of MATR3, PTB, PSF and HIV reactivation; Discovery of new host factors implicated in HIV-1 RNA nuclear export and HIV-1 post-transcriptional silencing; Select drugs to be validated in WP5	Documents, reports	2020-04-09 09:41:36
Determination of the potency, synergistic activity and toxicity of novel classes of LRA	Documents, reports	2020-04-09 09:41:36

Take a look to the deliverables list in detail: detailed list of EU4HIVCURE deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Ambra Sarracino, Lavina Gharu, Anna Kula, Alexander O. Pasternak, Veronique Avettand-Fenoel, Christine Rouzioux, Maryana Bardina, StÃ©phane De Wit, Monsef Benkirane, Ben Berkhout, Carine Van Lint, Alessandro Marcello Posttranscriptional Regulation of HIV-1 Gene Expression during Replication and Reactivation from Latency by Nuclear Matrix Protein MATR3 published pages: , ISSN: 2150-7511, DOI: 10.1128/mbio.02158-18	mBio 9/6	2020-04-09
2017	Ambra Sarracino, Alessandro Marcello The Relevance of Post-Transcriptional Mechanisms in HIV Latency Reversal published pages: , ISSN: 1381-6128, DOI: 10.2174/1381612823666170803102355	Current Pharmaceutical Design 23/28	2020-04-09
2017	Gilles Darcis, Sophie Bouchat, Anna Kula, Benoit Van Driessche, NadÃ¨ge Delacourt, Caroline Vanhulle, VÃ©ronique Avettand-Fenoel, StÃ©phane De Wit, Olivier Rohr, Christine Rouzioux, Carine Van Lint Reactivation capacity by latency-reversing agents ex vivo correlates with the size of the HIV-1 reservoir published pages: 181-189, ISSN: 0269-9370, DOI: 10.1097/QAD.0000000000001290	AIDS 31/2	2020-04-09
2016	Valentin Le Douce, Amina Ait-Amar, Faezeh Forouzan far, Faiza Fahmi, Jose Quiel, Hala El Mekdad, Fadoua Daouad, CÃ©line Marban, Olivier Rohr, Christian Schwartz Improving combination antiretroviral therapy by targeting HIV-1 gene transcription published pages: 1311-1324, ISSN: 1472-8222, DOI: 10.1080/14728222.2016.1198777	Expert Opinion on Therapeutic Targets 20/11	2020-04-09
2016	Valentin Le Douce, Faezeh Forouzanfar, Sebastian Eilebrecht, Benoit Van Driessche, Amina Ait-Ammar, Roxane Verdikt, Yoshihito Kurashige, CÃ©line Marban, Virginie Gautier, Ermanno Candolfi, Arndt G. Benecke, Carine Van Lint, Olivier Rohr, Christian Schwartz HIC1 controls cellular- and HIV-1- gene transcription via interactions with CTIP2 and HMGA1 published pages: , ISSN: 2045-2322, DOI: 10.1038/srep34920	Scientific Reports 6/1	2020-04-09
2016	CÃ©line Marban, Faezeh Forouzanfar, Amina Ait-Ammar, Faiza Fahmi, Hala El Mekdad, Fadoua Daouad, Olivier Rohr, Christian Schwartz Targeting the Brain Reservoirs: Toward an HIV Cure published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2016.00397	Frontiers in Immunology 7	2020-04-09
2017	Christian Schwartz, Sophie Bouchat, CÃ©line Marban, Virginie Gautier, Carine Van Lint, Olivier Rohr, Valentin Le Douce On the way to find a cure: Purging latent HIV-1 reservoirs published pages: 10-22, ISSN: 0006-2952, DOI: 10.1016/j.bcp.2017.07.001	Biochemical Pharmacology 146	2020-04-09

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