Explore the words cloud of the GROWTHPATTERN project. It provides you a very rough idea of what is the project "GROWTHPATTERN" about.
The following table provides information about the project.
Coordinator |
INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA
Organization address contact info |
Coordinator Country | Austria [AT] |
Project website | https://kichevalab.com/home/erc-starting-grant |
Total cost | 1˙499˙119 € |
EC max contribution | 1˙499˙119 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2015-STG |
Funding Scheme | ERC-STG |
Starting year | 2016 |
Duration (year-month-day) | from 2016-07-01 to 2021-06-30 |
Take a look of project's partnership.
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1 | INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA | AT (KLOSTERNEUBURG) | coordinator | 1˙499˙119.00 |
Individuals of the same species vary widely in size, but their organs have reproducible proportions and patterns of cell types. How cell fate specification and tissue growth are coordinated during embryonic development to achieve this reproducibility is a fundamental question in biology. Yet, surprisingly little is known about the underlying mechanisms. A major challenge has been to obtain the quantitative data required to assess the dynamics and variability in growth, pattern and signalling by morphogens – molecules that regulate both cell fate specification and tissue growth. I recently established experimental and theoretical approaches that allowed me to reconstruct with unprecedented resolution the three-dimensional growth and pattern of mouse and chick spinal cord. My data revealed a previously unanticipated role of tissue growth dynamics in controlling pattern reproducibility. This quantitative framework provides an exciting opportunity to elucidate the biophysical and molecular mechanisms of growth and pattern coordination. I will use this unique position to understand: 1) how signalling by multiple morphogens is integrated to control pattern, 2) how morphogens control cell cycle kinetics, 3) how morphogen source and target tissue are coupled to achieve pattern reproducibility. To address these issues, I will build on my experience with quantitative analyses to design novel assays where signalling, cell cycle dynamics and transcriptomes can be precisely measured and manipulated with single cell resolution. I will exploit state-of-the-art genome editing techniques to uncouple the critical feedback links and gain a novel perspective on pattern reproducibility and morphogen function. The project will advance our fundamental understanding of tissue morphogenesis and provide novel insights relevant to understanding information processing by signal transduction cascades, morphogen gradient activity, tissue engineering, and cancer biology.
year | authors and title | journal | last update |
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2017 |
Anna Kicheva, Nicolas C. Rivron Creating to understand – developmental biology meets engineering in Paris published pages: 733-736, ISSN: 0950-1991, DOI: 10.1242/dev.144915 |
Development 144/5 | 2020-03-20 |
2017 |
Marcin Zagorski, Yoji Tabata, Nathalie Brandenberg, Matthias P. Lutolf, GaÅ¡per TkaÄik, Tobias Bollenbach, James Briscoe, Anna Kicheva Decoding of position in the developing neural tube from antiparallel morphogen gradients published pages: 1379-1383, ISSN: 0036-8075, DOI: 10.1126/science.aam5887 |
Science 356/6345 | 2020-03-20 |
2017 |
James Briscoe, Anna Kicheva The physics of development 100 years after D\'Arcy Thompson\'s “On Growth and Form†published pages: 26-31, ISSN: 0925-4773, DOI: 10.1016/j.mod.2017.03.005 |
Mechanisms of Development 145 | 2020-03-20 |
2018 |
Marketa Kaucka, Julian Petersen, Marketa Tesarova, Bara Szarowska, Maria Eleni Kastriti, Meng Xie, Anna Kicheva, Karl Annusver, Maria Kasper, Orsolya Symmons, Leslie Pan, Francois Spitz, Jozef Kaiser, Maria Hovorakova, Tomas Zikmund, Kazunori Sunadome, Michael P Matise, Hui Wang, Ulrika Marklund, Hind Abdo, Patrik Ernfors, Pascal Maire, Maud Wurmser, Andrei S Chagin, Kaj Fried, Igor Adameyko Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.34465 |
eLife 7 | 2020-03-20 |
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