MCTRinIA SIGNED
Resolution Pharmacology and Physiology of MCTR in Arthritis
Total Cost €
0EC-Contrib. €
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Explore the words cloud of the MCTRinIA project. It provides you a very rough idea of what is the project "MCTRinIA" about.
Project "MCTRinIA" data sheet
The following table provides information about the project.
| Coordinator |
QUEEN MARY UNIVERSITY OF LONDON
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Total cost | 1˙964˙303 € |
| EC max contribution | 1˙964˙303 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2015-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-03-01 to 2021-02-28 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | QUEEN MARY UNIVERSITY OF LONDON | UK (LONDON) | coordinator | 1˙964˙303.00 |
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Project objective
Chronic inflammation may result from failure of the host response to engage pro-resolving pathways. The current treatment armamentarium for chronic inflammatory conditions may lead to immune suppression. Thus, identification of novel therapeutics that control inflammation without immune suppression will provide an attractive alternative approach. This is especially important since incidence of these conditions increases with an ageing global population. In planaria, mice, human peripheral blood and milk I recently uncovered a new family of endogenous molecules, named Maresin Conjugates in Tissue Regeneration (MCTR). These potently regulate white blood cell responses, promote the resolution of acute inflammation and accelerate tissue regeneration. The aim of this Starting Grant is to identify pathways that lead to failed resolution in inflammatory arthritis, as a prototypical chronic inflammatory condition. The hypothesis is that MCTR biosynthesis is dysregulated in inflammatory arthritis, leading to an unbridled host response, chronic inflammation and tissue destruction. This proposal will employ a multipronged approach to test this hypothesis by 1) Determining MCTR regulation in self-resolving and delayed-resolving arthritis; 2) Investigating the host protective and tissue regenerative actions of MCTRs in inflammatory arthritis; 3) Establishing the MCTR biosynthetic pathway and 4) Determining the regulation if its components during self-limited and delayed-resolving arthritis. Anticipated results will uncover novel pathways that become dysregulated during failed resolution. Results from this Starting Grant will also identify targets and new therapeutic approaches that will engage pro-resolution programs as well as tissue regeneration in conditions characterised by persistent inflammation and hence failed resolution. This will lay the basis for informed structure-activity based studies and the design of therapeutics for treatment of chronic inflammatory conditions.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2017 |
Stephanie G. Dakin, Lucy Ly, Romain A. Colas, Udo Oppermann, Kim Wheway, Bridget Watkins, Jesmond Dalli, Andrew J. Carr Increased 15-PGDH expression leads to dysregulated resolution responses in stromal cells from patients with chronic tendinopathy published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-11188-y |
Scientific Reports 7/1 | 2019-07-08 |
| 2018 |
Nguyen TH Mai, Nicholas Dobbs, Nguyen Hoan Phu, Romain A Colas, Le TP Thao, Nguyen TT Thuong, Ho DT Nghia, Nguyen HH Hanh, Nguyen T Hang, A Dorothee Heemskerk, Jeremy N Day, Lucy Ly, Do DA Thu, Laura Merson, Evelyne Kestelyn, Marcel Wolbers, Ronald Geskus, David Summers, Nguyen VV Chau, Jesmond Dalli, Guy E Thwaites A randomised double blind placebo controlled phase 2 trial of adjunctive aspirin for tuberculous meningitis in HIV-uninfected adults published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.33478 |
eLife 7 | 2019-07-08 |
| 2018 |
Kimberly Pistorius, Patricia R. Souza, Roberta De Matteis, Shani Austin-Williams, Karoline G. Primdahl, Anders Vik, Francesca Mazzacuva, Romain A. Colas, Raquel M. Marques, Trond V. Hansen, Jesmond Dalli PDn-3 DPA Pathway Regulates Human Monocyte Differentiation and Macrophage Function published pages: 749-760.e9, ISSN: 2451-9456, DOI: 10.1016/j.chembiol.2018.04.017 |
Cell Chemical Biology 25/6 | 2019-07-08 |
| 2018 |
Jesmond Dalli, Charles N Serhan Identification and structure elucidation of the pro-resolving mediators provides novel leads for resolution pharmacology published pages: , ISSN: 0007-1188, DOI: 10.1111/bph.14336 |
British Journal of Pharmacology | 2019-07-08 |
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