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STC SIGNED

Synaptic Tagging and Capture: From Synapses to Behavior

Total Cost €

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EC-Contrib. €

0

Partnership

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 STC project word cloud

Explore the words cloud of the STC project. It provides you a very rough idea of what is the project "STC" about.

explicit    potentiation    plasticity    explicitly    underlies    optical    two    naturally    manipulation    put    proteins    induction    predictions    grant    small    divided    predicts    synaptic    optogenetic    neuronal    cellular    stc    converging    resolution    optically    preceded    stability    memory    proposes    protein    capturing    ltp    basis    inducible    stabilized    associates    followed    populations    natural    heterosynaptic    stable    spatial    precise    forgotten    inducing    optogenetics    animal    permits    it    shock    synthesis    color    selective    fraction    fear    activated    hypothesis    transiently    happening    manipulating    expression    associative    examine    induce    tone    amygdala    mechanism    neurons    temporal    remarkably    made    foot    inputs    activation    dependent    caused    circuit    stabilization    shown    formed    tagged    visual    engineer    model    capture    tagging    memories    stimulus    population    subsequently    stimuli    auditory    events    stabilize   

Project "STC" data sheet

The following table provides information about the project.

Coordinator
AARHUS UNIVERSITET 

Organization address
address: NORDRE RINGGADE 1
city: AARHUS C
postcode: 8000
website: www.au.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AARHUS UNIVERSITET DK (AARHUS C) coordinator 1˙500˙000.00

Map

 Project objective

It is shown that long-term potentiation (LTP) is the cellular basis of memory formation. However, since all but small fraction of memories are forgotten, LTP has been further divided into early LTP (e-LTP), the mechanism by which short-term memories are formed, and a more stable late LTP (L-LTP), by which long-term memories are formed. Remarkably, it has been shown that an e-LTP can be stabilized if it is preceded or followed by heterosynaptic L-LTP. According to Synaptic Tagging and Capture (STC) hypothesis, e-LTP is stabilized by capturing proteins that are made by L-LTP induction. The model proposes that this mechanism underlies the formation of late associative memory, where the stability of a memory is not only defined by the stimuli that induce the change but also by events happening before and after these stimuli. As such, the model explicitly predicts that a short-term memory can be stabilized by inducing heterosynaptic L-LTP. In this grant, I will put this hypothesis into test. Specifically, I will test two explicit predictions of STC model: 1) A naturally formed short-term memory can be stabilized by induction of heterosynaptic L-LTP. 2) This stabilization is caused by the protein synthesis feature of L-LTP. To do this, using optogenetics, I will engineer a short-term memory in auditory fear circuit, in which an animal transiently associates a foot shock to a tone. Subsequently, I will examine if optogenetic delivery of L-LTP to the visual inputs converging on the same population of neurons in the amygdala will stabilize the short-term tone fear memory. To be able to engineer natural memory by manipulating synaptic plasticity I will develop two systems: 1) A two-color optical activation system which permits selective manipulation of distinct neuronal populations with precise temporal and spatial resolution; 2) An inducible and activity-dependent expression system by which those neurons that are activated by a natural stimulus will be optically tagged.

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The information about "STC" are provided by the European Opendata Portal: CORDIS opendata.

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