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PhageResist SIGNED

Beyond CRISPR: Systematic characterization of novel anti-phage defense systems in the microbial pan-genome

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

PhageResist project word cloud

Explore the words cloud of the PhageResist project. It provides you a very rough idea of what is the project "PhageResist" about.

throughput genetic ed uncharacterized influence microbes mechanisms combines restriction cas discover resistance enzymes half evolution arms experiments verify sequenced genomics biochemical synthetic assays defense protect race contain genomes biology biotechnological additional learned infection struggle bacterial proven encoded understand efficient perpetual bacteria robotic disposal deep invaluable computational phages systematically molecular crispr phage arsenal anti

Project "PhageResist" data sheet

The following table provides information about the project.

Coordinator	WEIZMANN INSTITUTE OF SCIENCE Organization address address: HERZL STREET 234 city: REHOVOT postcode: 7610001 website: www.weizmann.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Israel [IL]
Total cost	2˙000˙000 €
EC max contribution	2˙000˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2015-CoG
Funding Scheme	ERC-COG
Starting year	2016
Duration (year-month-day)	from 2016-07-01 to 2021-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	WEIZMANN INSTITUTE OF SCIENCE WEIZMANN INSTITUTE OF SCIENCE Organization address address: HERZL STREET 234 city: REHOVOT postcode: 7610001 website: www.weizmann.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (REHOVOT)	coordinator	2˙000˙000.00

Map

Project objective

The perpetual arms race between bacteria and phage has resulted in the evolution of efficient resistance systems that protect bacteria from phage infection. Such systems, which include restriction enzymes and CRISPR-Cas, have major influence on the evolution of both bacteria and phage, and have also proven to be invaluable for molecular and biotechnological applications. Although much have been learned on the biology of bacterial defense against phage, more than half of all sequenced bacteria do not contain CRISPR-Cas, and it is estimated that many additional, yet-uncharacterized anti-phage defense systems are encoded in bacterial genomes.

The goal of this project is to systematically understand the arsenal of defense mechanisms that are at the disposal of microbes in their struggle against phages. The project combines computational genomics, synthetic biology, high-throughput robotic assays, and deep genetic and biochemical experiments to discover, verify, and study the properties of anti-phage defense systems.

Publications

List of publications.
year	authors and title	journal	last update
2017	Zohar Erez, Ida Steinberger-Levy, Maya Shamir, Shany Doron, Avigail Stokar-Avihail, Yoav Peleg, Sarah Melamed, Azita Leavitt, Alon Savidor, Shira Albeck, Gil Amitai, Rotem Sorek Communication between viruses guides lysisâ€“lysogeny decisions published pages: 488-493, ISSN: 0028-0836, DOI: 10.1038/nature21049	Nature 541/7638	2019-06-18
2018	Shany Doron, Sarah Melamed, Gal Ofir, Azita Leavitt, Anna Lopatina, Mai Keren, Gil Amitai, Rotem Sorek Systematic discovery of antiphage defense systems in the microbial pangenome published pages: eaar4120, ISSN: 0036-8075, DOI: 10.1126/science.aar4120	Science 359/6379	2019-06-05
2018	MÃ©lodie Duval, Daniel Dar, Filipe Carvalho, Eduardo P. C. Rocha, Rotem Sorek, Pascale Cossart HflXr, a homolog of a ribosome-splitting factor, mediates antibiotic resistance published pages: 13359-13364, ISSN: 0027-8424, DOI: 10.1073/pnas.1810555115	Proceedings of the National Academy of Sciences 115/52	2019-06-05
2018	Dar, Daniel; Sorek, Rotem High-resolution RNA 3â€²-ends mapping of bacterial Rho-dependent transcripts published pages: , ISSN: 0305-1048, DOI: 10.1093/nar/gky274	Nucleic Acids Research 1	2019-06-05
2018	Daniel Dar, Rotem Sorek Extensive reshaping of bacterial operons by programmed mRNA decay published pages: e1007354, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1007354	PLOS Genetics 14/4	2019-06-05
2016	MoranÂ G. Goren, Shany Doron, Rea Globus, Gil Amitai, Rotem Sorek, Udi Qimron Repeat Size Determination by Two Molecular Rulers in the Type I-E CRISPR Array published pages: 2811-2818, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2016.08.043	Cell Reports 16/11	2019-06-05

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The information about "PHAGERESIST" are provided by the European Opendata Portal: CORDIS opendata.