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PlaEndo

The Remote Control of Maternal Metabolism by the Placenta

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

PlaEndo project word cloud

Explore the words cloud of the PlaEndo project. It provides you a very rough idea of what is the project "PlaEndo" about.

genetic physiological hormones reactive secreting technologies actions function genetically modified tools significance cell systemic lines shown cardiovascular mother endocrine abnormal association isolated primarily nature metabolic insulin cultured pregnancy gained adapting during medical candidates first hormone placental baby capacity protein experimental whilst mediators preventing maternal adaptations university signaling tested region secreted interventions fetus placenta glucose complications designed optimizing birth biological mouse becomes pulmonary relies body conveniently adjust fetal organism metabolism independent diabetes principally sequencing latest cells model signaled cambridge pregnant weight immune thought

Project "PlaEndo" data sheet

The following table provides information about the project.

Coordinator	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	https://www.pdn.cam.ac.uk/other-pages/sferruzzi-perri/amanda-sferruzzi-perri-lab-members
Total cost	195˙454 €
EC max contribution	195˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-ST
Starting year	2016
Duration (year-month-day)	from 2016-09-01 to 2018-09-25

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	coordinator	195˙454.00

Map

Project objective

During pregnancy many physiological changes occur in the mother that are designed to support fetal growth. These include changes in the cardiovascular, pulmonary, immune and metabolic systems. In particular, the mother becomes less reactive to insulin, leading to increased glucose availability to the fetus in late pregnancy. These adaptations are thought to be signaled, in part by changes in placental hormone production. Whilst studies have shown that the placenta has the capacity to produce different hormones, their specific role in adapting maternal metabolism during pregnancy relies principally on association studies. Moreover, there are likely to be more protein mediators secreted by the placenta with systemic actions in the mother. Failure to adjust the mother's body to the pregnant state may result in pregnancy complications, including abnormal birth weight and maternal diabetes, which can further lead to a range of medical complications for the mother and baby. The overall goal of this study will be to identify the nature and wider biological significance of placental endocrine function in adapting the mother's body during pregnancy to support fetal growth, with a focus on maternal metabolism. This work will primarily use the mouse as an experimental model as the placental signaling/secreting cells are conveniently organized into a distinct region and are under unique genetic control. Therefore placental signaling cells can be isolated, cultured and genetically-modified independent of other cells in the mouse placenta. The secreted placental candidates will be identified using the latest sequencing technologies, and their metabolic effects will be tested on cell lines and in the whole organism using unique genetic tools available at the University of Cambridge. Knowledge gained from this study will be the first step in the development of targeted interventions for optimizing fetal growth and preventing pregnancy complications.

Publications

List of publications.
year	authors and title	journal	last update
2018	Tina Napso, Hannah E. J. Yong, Jorge Lopez-Tello, Amanda N. Sferruzzi-Perri The Role of Placental Hormones in Mediating Maternal Adaptations to Support Pregnancy and Lactation published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2018.01091	Frontiers in Physiology 9	2019-05-30

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The information about "PLAENDO" are provided by the European Opendata Portal: CORDIS opendata.