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DISTRICT

DECIPHERING THE ROLE OF TRIB1 IN REGULATORY T CELLS

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

DISTRICT project word cloud

Explore the words cloud of the DISTRICT project. It provides you a very rough idea of what is the project "DISTRICT" about.

cells deciphering organ free cancer discovering master homeostasis suggest combinaison function counterpart modulate models reported tregs explored treat decipher molecule ve signalling strategies comprehension molecular functions biology vitro transcription vivo highlighting immunotherapy links tribbles regulatory expression foxp3 expansion mechanisms tolerance na diseases iuml mechanistic suppressive immune interacts peripheral axes trib1 treg implication transplantation immunosuppression

Project "DISTRICT" data sheet

The following table provides information about the project.

Coordinator	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Project website	http://crti.univ-nantes.fr/
Total cost	185˙076 €
EC max contribution	185˙076 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-07-01 to 2019-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	coordinator	185˙076.00

Map

Project objective

The role of regulatory T cells (Tregs) is crucial to maintain immune homeostasis by controlling peripheral tolerance. A better understanding in the molecular mechanisms involved in the biology of these Treg cells could improve their expansion and selection to treat immune-related diseases, achieve immunosuppression-free organ transplantation and to specifically target them in cancer. We reported on the over-expression of Tribbles-1 (TRIB1) in Tregs compared to their counterpart naïve T cells and that TRIB1 interacts with the master molecule of Tregs, FOXP3, a transcription factor essential for Treg suppressive activity. These results suggest still non explored potential links between TRIB1 in Tregs biology. Our goal is thus to decipher the role of TRIB1 in the Treg homeostasis and functions, through 3 main axes: 1) deciphering the function of TRIB1 in Tregs in vitro, 2) highlighting its implication in vivo using a combinaison of immune-related models and 3) discovering the signalling pathway of TRIB1 in Tregs. These results would not only increase TRIB1 mechanistic knowledge but also increase comprehension of Treg biology and bring opportunities to identify new strategies to modulate Tregs for immunotherapy.

Publications

List of publications.
year	authors and title	journal	last update
2019	Lyssia Belarif, Richard Danger, Laetitia Kermarrec, VÃ©ronique NerriÃ¨re-Daguin, Sabrina Pengam, Tony Durand, Caroline Mary, Elise Kerdreux, Vanessa Gauttier, Aneta Kucik, Virginie Thepenier, Jerome C. Martin, Christie Chang, Adeeb Rahman, Nina Salabert-Le Guen, CÃ©cile Braudeau, Ahmed Abidi, GrÃ©goire David, Florent Malard, Celine Takoudju, Bernard Martinet, Nathalie GÃ©rard, Isabelle Neveu, Mich IL-7 receptor influences anti-TNF responsiveness and T cell gut homing in inflammatory bowel disease published pages: 1910-1925, ISSN: 0021-9738, DOI: 10.1172/jci121668	Journal of Clinical Investigation 129/5	2019-11-20

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