Explore the words cloud of the EBOPATH project. It provides you a very rough idea of what is the project "EBOPATH" about.
The following table provides information about the project.
Coordinator |
BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN
Organization address contact info |
Coordinator Country | Germany [DE] |
Project website | https://www.bnitm.de |
Total cost | 171˙460 € |
EC max contribution | 171˙460 € (100%) |
Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
Code Call | H2020-MSCA-IF-2015 |
Funding Scheme | MSCA-IF-EF-ST |
Starting year | 2016 |
Duration (year-month-day) | from 2016-11-01 to 2018-10-31 |
Take a look of project's partnership.
# | ||||
---|---|---|---|---|
1 | BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN | DE (HAMBURG) | coordinator | 71˙442.00 |
2 | HEINRICH-PETTE INSTITUT LEIBNIZ INSTITUT FUER EXPERIMENTELLE VIROLOGIE | DE (HAMBURG) | participant | 100˙018.00 |
Ebolaviruses comprise five virus species of which at least three are highly pathogenic for humans. Other mammalian species such as non-human primates, forest antelopes and pigs are susceptible to ebolavirus infection with different degree of severity. However, bats and laboratory mice are entirely resistant to ebolaviruses. Why do ebolaviruses cause severe disease in some species but not others? This question, which is paramount to understand ebolavirus pathogenesis is the central question of our proposal. To address it, we will build on technology developed by the host laboratory to develop xenochimeric mice, that is, severely immunodeficient mice whose hematopoietic system has been replaced with another from a donor species (e. g. bats, monkeys or humans). This novel in vivo system will allow us to investigate the kinetics of ebolavirus infection across species and to dissect the mechanisms responsible for pathogenicity.
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The information about "EBOPATH" are provided by the European Opendata Portal: CORDIS opendata.