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EBOPATH

Evaluation of species-specific ebolavirus pathophysiology in xenochimeric mice

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

EBOPATH project word cloud

Explore the words cloud of the EBOPATH project. It provides you a very rough idea of what is the project "EBOPATH" about.

primates host degree donor understand laboratory responsible antelopes human severe central infection comprise pathogenesis vivo mammalian severity question ebolavirus pigs others virus pathogenicity disease kinetics mice pathogenic monkeys hematopoietic bats susceptible severely replaced dissect paramount resistant xenochimeric least species immunodeficient mechanisms humans entirely forest ebolaviruses

Project "EBOPATH" data sheet

The following table provides information about the project.

Coordinator	BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN Organization address address: BERNHARD NOCHT STRASSE 74 city: HAMBURG postcode: 20359 website: www.bni.uni-hamburg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	https://www.bnitm.de
Total cost	171˙460 €
EC max contribution	171˙460 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-ST
Starting year	2016
Duration (year-month-day)	from 2016-11-01 to 2018-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN Organization address address: BERNHARD NOCHT STRASSE 74 city: HAMBURG postcode: 20359 website: www.bni.uni-hamburg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HAMBURG)	coordinator	71˙442.00
2	HEINRICH-PETTE INSTITUT LEIBNIZ INSTITUT FUER EXPERIMENTELLE VIROLOGIE HEINRICH-PETTE INSTITUT LEIBNIZ INSTITUT FUER EXPERIMENTELLE VIROLOGIE Organization address address: MARTINISTRASSE 52 city: HAMBURG postcode: 20251 website: www.hpi-hamburg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HAMBURG)	participant	100˙018.00

Map

Project objective

Ebolaviruses comprise five virus species of which at least three are highly pathogenic for humans. Other mammalian species such as non-human primates, forest antelopes and pigs are susceptible to ebolavirus infection with different degree of severity. However, bats and laboratory mice are entirely resistant to ebolaviruses. Why do ebolaviruses cause severe disease in some species but not others? This question, which is paramount to understand ebolavirus pathogenesis is the central question of our proposal. To address it, we will build on technology developed by the host laboratory to develop xenochimeric mice, that is, severely immunodeficient mice whose hematopoietic system has been replaced with another from a donor species (e. g. bats, monkeys or humans). This novel in vivo system will allow us to investigate the kinetics of ebolavirus infection across species and to dissect the mechanisms responsible for pathogenicity.

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The information about "EBOPATH" are provided by the European Opendata Portal: CORDIS opendata.