The page lists 195 projects related to the topic "pathogenesis".
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1 | ParaFishControl | Advanced Tools and Research Strategies for Parasite Control in European farmed fish | 2015 |
2 | CARBALIVE | Clinical evaluation of carbons of controlled porosity as a new therapeutic for the treatment of liver cirrhosis and non-alcoholic fatty liver disease. | 2015 |
3 | PROPAG-AGEING | The continuum between healthy ageing and idiopathic Parkinson Disease within a propagation perspective of inflammation and damage: the search for new diagnostic, prognostic and therapeutic targets | 2015 |
4 | PredicTOOL | Nanomethods to understand what makes an endogenous protein immunogenic | 2015 |
5 | ApoptoMDS | Hematopoietic stem cell Apoptosis in bone marrow failure and MyeloDysplastic Syndromes: Friend or foe? | 2015 |
6 | SILENCE | Mechanisms of Gene Silencing by the Glucocorticoid Receptor | 2015 |
7 | FLDcure | A potent Micro-RNA therapeutic for nonalcoholic fatty liver disease (NAFLD) | 2015 |
8 | SOS | Sorting of Self | 2015 |
9 | CLOSPORE | UNDERSTANDING THE CLOSTRIDIUM SPORE, A PREREQUISTE FOR DISEASE INTERVENTIONS AND EXPLOITATION | 2015 |
10 | Brain Metastases | The Role of Circulating Monocytes in the Development of Brain Metastases | 2015 |
11 | Inflammafish | Cross-talk between inflammation and autophagy in tuberculosis | 2016 |
12 | mini-liver SCCS | Human “mini-liver” stem cell culture systems: from mechanisms behind liver cancer origin and recurrence to new therapeutic treatments | 2016 |
13 | KSHV QTV | Identification of novel KSHV immune evasion mechanisms using a quantitative temporal viromics analysis | 2015 |
14 | INSCAPE | Imaging Voltage Gated Sodium Channels Using Positron Emission Tomography | 2015 |
15 | BURK-6 | Investigation of the Type VI secretion system-associated toxins of Burkholderia thailandensis | 2015 |
16 | RECOLOR | Regulation and consequences of LRRK2 phosphorylation,a path to Parkinson’s disease therapy and diagnostics | 2015 |
17 | BactoDrug | The Bacteroides dual-pumping membrane-integral pyrophosphatase: a novel drug target | 2015 |
18 | Athero MPh proliferation | Macrophage proliferation and ontogeny in murine models of atherosclerosis | 2016 |
19 | HBV1 | Innate immune responses to human hepatotropic viral infections | 2015 |
20 | FAtoUnFRAGILITY | Fanconi anemia : a disease model to understand causes and consequences of common fragile site instability. | 2015 |
21 | C9ND | C9orf72-mediated neurodegeneration: mechanisms and therapeutics | 2015 |
22 | OPTIMALZ | Optical imaging of ocular pathology in Alzheimer’s disease | 2015 |
23 | DevoTed_miR | MicroRNA determinants of the balance between effector and regulatory T cells in vivo | 2015 |
24 | RENOIR | RENal prOgenItoRs as tools to understand kidney pathophysiology and treat kidney disorders | 2015 |
25 | BIOCONT6SS | Inter-bacterial competition mediated by the type VI secretion system (T6SS): promising role in the biocontrol properties of Pseudomonas putida | 2016 |
26 | PRIISM-HD | Pathways Regulating Intramyocellular Insulin Sensitivity and Metabolism in Health and Disease | 2016 |
27 | OxygenSensing | Molecular mechanisms of acute oxygen sensing. | 2015 |
28 | LeukoTheranostics | Harnessing Targeted Nanotheranostics to Reprogram Activated Leukocytes in Inflammatory Bowel Disease | 2015 |
29 | HEPCIR | Cell circuits as targets and biomarkers for liver disease and cancer prevention | 2016 |
30 | NutrientSensingVivo | The Physiology of Nutrient Sensing by mTOR | 2016 |
31 | M-Imm | Novel etiology of autoimmune disorders: the role of acquired somatic mutations in lymphoid cells | 2015 |
32 | RUBICON | Training network for Research on molecUlar and Biomechanical Interactions in CONnective tissue disorders | 2016 |
33 | SWEETOOLS | Smart Biologics: Developing New Tools in Glycobiology | 2016 |
34 | PREG-LAB | Distinctive characterization of regulatory plasma cells and pro-inflammatory B cells in immunity: their origins, molecular properties, and cellular fates. | 2016 |
35 | HEP-CAR | Mechanisms underlying hepatocellular carcinoma pathogenesis and impact of co-morbidities. | 2016 |
36 | CoSTREAM | Common mechanisms and pathways in Stroke and Alzheimer's disease. | 2015 |
37 | VIVALDI | Preventing and mitigating farmed bivalve diseases | 2016 |
38 | GvHDCure | Understanding the dynamics of the immune system to cure graft-versus-host disease (GvHD). | 2016 |
39 | ESA -ITN | European Sepsis Academy: towards new biomarkers to improve sepsis management | 2016 |
40 | DISSection | Doctoral Industrial School on Human Skin models for Staphylococcal infections | 2016 |
41 | CaNANObinoids | From Peripheralized to Cell- and Organelle-Targeted Medicine: The 3rd Generation of Cannabinoid-1 Receptor Antagonists for the Treatment of Chronic Kidney Disease | 2016 |
42 | NEUTRO-LILR | Leukocyte immunoglobulin-like receptors (LILRs) on neutrophils | 2016 |
43 | IFNBetaMito | Role of IFN-β in mitochondrial homeostasis and impact on Parkinson Disease | 2016 |
44 | a-Sign | Cyclic nucleotide signalling in the human pathogen Listeria monocytogenes | 2016 |
45 | Prionomics | Systematic profiling of molecular changes during prion disease progression | 2016 |
46 | EBOPATH | Evaluation of species-specific ebolavirus pathophysiology in xenochimeric mice | 2016 |
47 | METAFORA | Miniaturised Metabolomics Platform for Microvascular Research | 2016 |
48 | ChondUb | Identification and characterisation of novel WWP2 substrates and their role in chondrogenesis and osteoarthritis | 2016 |
49 | EpiHope | Epigenetic biomarkers for prediction of vascular complications and response to treatment in subjects with diabetes | 2016 |
50 | REGDAM | REGULATORY T CELLS AND TISSUE DAMAGE CONTROL | 2017 |
51 | Ubl-Code | Revealing the ubiquitin and ubiquitin-like modification landscape in health and disease | 2016 |
52 | CentSatRegFunc | Dissecting the function and regulation of centriolar satellites: key regulators of the centrosome/cilium complex | 2016 |
53 | BoneMalar | Mechanisms of bone marrow sequestration during malaria infection | 2016 |
54 | PANDORA | Platelets: at the nexus of brain aneurysm | 2016 |
55 | PIGYVAX | Making a yeast-based candidate vaccine against Porcine Epidemic Diarrhea Virus (PEDV) | 2016 |
56 | IMCIS | Individualised medicine in chronic inflammatory skin diseases | 2016 |
57 | ToxoPersist | Molecular Basis of Toxoplasma gondii Encystation and Persistence | 2016 |
58 | INVADIS | Microbial invasion and dissemination within the host, mechanisms and effects | 2016 |
59 | BCM-UPS | Dissecting the role of the ubiquitin proteasome system in the pathogenesis and therapy of B-cell malignancies | 2016 |
60 | ZMOD | Blood Vessel Development and Homeostasis: Identification and Functional Analysis of Genetic Modifiers | 2016 |
61 | Autonomous CLL-BCRs | Role of autonomous B cell receptor signalling and external antigen in the pathogenesis of chronic lymphocytic leukaemia (CLL) | 2016 |
62 | IMMUNOALZHEIMER | The role of immune cells in Alzheimer's disease | 2016 |
63 | iPSCAtaxia | An induced pluripotent stem cell-based neuronal model of Spinocerebellar ataxia | 2016 |
64 | AD-VIP | Alzheimer’s disease and AAV9: Use of a virus-based delivery system for vectored immunoprophylaxis in dementia. | 2016 |
65 | HypoFlam | Targeting hypothalamic inflammation in obesity and diabetes | 2016 |
66 | Foie Gras | Bioenergetic Remodeling in the Pathophysiology and Treatment of Non-Alcoholic Fatty Liver Disease | 2017 |
67 | DIAL-IN | Dynamic Integrated structural and proteomic Analysis of the LUBAC complex and its involvement in NF-κB and inflammation | 2016 |
68 | PATHAD | Pathways to Alzheimer's disease | 2016 |
69 | ZIKAction | ZIKAction: Preparedness, research and action network on maternal-paediatric axis of ZIKV infection in Latin America and the Caribbean | 2016 |
70 | mtFOIE GRAS | mitoFOIE GRAS: Non-invasive Profiling of Mitochondrial Function in Non-Alcoholic Fatty Liver Disease | 2017 |
71 | miRCaP | Innovative nanoparticle formulation for a miR-133 based treatment of cardiac hypertrophy | 2016 |
72 | BONEPHAGY | Defining the role of the FGF – autophagy axis in bone physiology | 2017 |
73 | MODulATE | Gut microbiota-dependent tryptophan metabolism: role in disease pathogenesis and therapeutic target | 2017 |
74 | MYCONEUTROPHILS | Elucidating the involvement of neutrophils in the pathogenesis of tuberculosis using a zebrafish model | 2017 |
75 | NEW-AGE | A next-generation platform for catalysing pre-clinical development of drugs against Alzheimer’s and other degenerative diseases of old-age | 2017 |
76 | CARBOFLU | Chemoenzymatic synthesis of complex glycans to decipher the interactions between them and Influenza A virus | 2017 |
77 | LamelliActin | Mechanical Adaptation of Lamellipodial Actin Networks in Migrating Cells | 2017 |
78 | PROZE | Using a protein approach with Waddlia chondrophila and zebrafish as model organisms to conquer the female tubal factor subfertility market | 2017 |
79 | MIRA | Characterizing Microbe-specific Immune Responses in the pathogenesis of Autoimmunity | 2017 |
80 | REVERSING TAUOPATHY | Identifying and deciphering the mechanism of the cellular machinery responsible for disaggregation of intracellular prion-like Tau aggregates | 2017 |
81 | REACT | Uncovering the role of cis genetic elements in antigenic variation of Plasmodium falciparum using the CRISPR-Cas9 genome editing technology | 2018 |
82 | SupaSteD | Suppresion of adaptive immunity by the Salmonella effector SteD | 2017 |
83 | ExItALS | RNA-mediated intercellular miscommunication: role of extracellular vesicle cargos in Amyotrophic Lateral Sclerosis | 2017 |
84 | MiRCHOL | Mechanistic and therapeutic implications of microRNA deregulation for drug resistance in bile duct cancer | 2017 |
85 | HUNTINFISH | Generation of new zebrafish models for the study of the pathogenesis of Huntington´s disease and for the identification of new therapeutic targets. | 2018 |
86 | PERISCOPE | PERtussIS COrrelates of Protection Europe - Sofia ref.: 115910 | 2016 |
87 | BEAt-DKD | Biomarker Enterprise to Attack DKD - Sofia ref.: 115974 | 2016 |
88 | PI3K-VAs | Activation of PI3K signalling in the pathogenesis of Vascular Anomalies | 2018 |
89 | METCLL | Discovery and validation of ‘epidrivers’ of cancer evolution and resistance to therapy | 2018 |
90 | ESCRT model | A biophysical model for ESCRT-III mediated membrane scission | 2017 |
91 | HOST-SELECT | Functional Analysis of Host Genetic Variants: Biomarker Selection Towards Improving Female Subfertility Diagnosis and Treatment | 2017 |
92 | IAV-m6A | Elucidating the role of m6A RNA methylation on the replication and pathogenesis of influenza A virus. | 2017 |
93 | MRI-STRUCTURE | MRI Signal To Recover Unique Cerebral TissUe Response to changEs | 2018 |
94 | DISMOD-HD | Direct reprogramming for HD Disease Modelling | 2017 |
95 | OMPorg | Spatiotemporal organisation of bacterial outer membrane proteins | 2017 |
96 | 3DviralRNA | Structural and functional characterization of large viral and human non-coding RNA motifs involved in HIV infection | 2018 |
97 | EpiFAT | Epigenomic Reprogramming of Adipose Tissue Function and Energy Metabolism in Type 2 Diabetes | 2017 |
98 | GENDOSIS | GENOTYPE - ENDOPHENOTYPE ASSOCIATIONS IN PSYCHOSIS | 2017 |
99 | iHEAR | Investigating the meanings and mechanisms of psychotic experiences in young people: a novel, mixed-methods approach | 2017 |
100 | PIGSs | Program for Innovative Global Prevention of Streptococcus suis. | 2017 |
101 | NAFLDcure | A novel pharmaceutical treatment for nonalcoholic fatty liver disease | 2017 |
102 | FATE | Functional Biology of Hepatic CD8+ T cells | 2017 |
103 | ENLIGHTEN | INTEGRATION AND PROPAGATION OF IMMUNOLOGICAL SIGNALS DURING CANCER AND INFECTION | 2018 |
104 | NEMESIS | Neuron/mast cell interactions in skin diseases | 2017 |
105 | BrainDrain | Translational implications of the discovery of brain-draining lymphatics | 2017 |
106 | EuroNeurotrophin | A European training network for the discovery of neurotrophins small molecule mimetics as candidate therapeutic agents for neurodegeneration and neuroinflammation | 2018 |
107 | PD UpReg | Gene knock-up via 3’UTR targeting to treat Parkinson’s disease | 2017 |
108 | LUPUSCARE | PRECISION CARE IN SYSTEMIC AUTOIMMUNITY: AN INTEGRATED MULTI-TISSUE/LEVEL APPROACH FOR SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) | 2017 |
109 | DecodingInfection | Decoding the host-pathogen interspecies crosstalk at a multiparametric single-cell level | 2017 |
110 | deFIBER | Dissecting the cellular and molecular dynamics of bone marrow fibrosis for improved diagnostics and treatment | 2018 |
111 | CSI-Fun | Chronic Systemic Inflammation: Functional organ cross-talk in inflammatory disease and cancer | 2018 |
112 | AstroNeuroCrosstalk | Astrocyte-Neuronal Crosstalk in Obesity and Diabetes | 2018 |
113 | DIAMONDCOR | A molecular approach to treat diabetes mellitus onset dependent coronaropathy | 2018 |
114 | PyraSig | Pyrazine Signalling in Commensal and Pathogenic Bacteria | 2018 |
115 | WISH | WISH – Wearable Integrated System for Early Detection of Preterm Labour | 2017 |
116 | MRS in diabetes | Novel methods in Magnetic Resonance Spectroscopy to investigate mechanisms underlying metabolic disease | 2018 |
117 | Damocles | Modelling brain aneurysm to elucidate the role of platelets | 2018 |
118 | DynaMO_TB | Spatiotemporal regulation of localization and replication of M. tuberculosis in humanmacrophages | 2018 |
119 | CLLCLONE | Harnessing clonal evolution in chronic lymphocytic leukemia | 2018 |
120 | iPS-ChOp-AF | Combining induced pluripotent stem cells, tissue engineering, optogenetic and chemogenetic concepts for the study and treatment of atrial fibrillation | 2018 |
121 | BIONICS | A biomimetic and neuroprotective delivery nanocapsule for the targeted treatment of post-ischemic stroke effects | 2018 |
122 | Alpha-Synuclein | Blocking the prion-like disease propagation in Parkinson’s disease and related disorders – model development and identification of cell-autonomous and cell non-autonomous factors. | 2019 |
123 | NEUROGUIDE | Study of neuronal sensing and migration/guidance dynamics in neurodevelopmental disorders by nano-engineered chips | 2018 |
124 | TOPNIN | Tracing of pulmonary neuro-immune networks | 2018 |
125 | cureCD | Function of long non-coding RNA in Crohn Disease Ulcer Pathogenesis | 2018 |
126 | ImmunAID | Immunome project consortium for AutoInflammatory Disorders | 2018 |
127 | HGB-StIC | Human Genetic Basis of Severe Staphylococcal Infections in Childhood | 2019 |
128 | HifLICs | Acute Myeloid Leukemia Leukemic Initiating Cells: Contribution of hypoxia/HIF pathway to chemoresistance and relapse | 2019 |
129 | MS-fMRI-QSM | Studying Multiple Sclerosis with a novel simultaneous functional Magnetic Resonance Imaging (fMRI) and Quantitative Susceptibility Mapping (QSM) sequence. | 2019 |
130 | PREMNEC | PReterm Enteroids to determine the Mechanism of Necrotising EnteroColitis | 2018 |
131 | IGpath | Dissecting the functional pathways of B cell receptor immunoglobulin in antigen driven mature B cell lymphomas | 2018 |
132 | iNtoPoreAge | Assessing transcriptional and nuclear pore aging in age-equivalent and rejuvenated induced neurons from Alzheimer patients | 2019 |
133 | Gut-AnorexiaNervosa | Metagenomics and metabolomics studies of patients with Anorexia Nervosa to identify intestinal microbial mechanisms contributing to pathogenesis | 2018 |
134 | GLIAMAC | Uncovering Enteric GLIA-MACrophage communication in the intestinal homeostasis and inflammation | 2018 |
135 | INFLA-AID | The role of NLRC4 inflammasome in autoinflammatory diseases | 2018 |
136 | Neuronetmir | Role of miR-129-5p and Rbfox1 crosstalk in neural network homeostasis | 2018 |
137 | NEVULA | Understanding selective neuronal vulnerability in Alzheimer’s disease | 2018 |
138 | ProMeta | Non-histone protein acetylation targets of KAT2A in AML | 2018 |
139 | NECROPTOSIS | Necroptosis in immunity, inflammation and autoimmunity induced by nucleic acid sensors | 2018 |
140 | mTORmorS | Role of mTOR signaling dysregulation in the tumor suppressor networks in hepatocellular carcinoma | 2019 |
141 | ASSYSt | A reliable CXCL4 biomarker assay to improve diagnosis and treatment of Systemic Sclerosis | 2018 |
142 | OrganoVIR | Organoids for Virus Research - An innovative training-ETN programme | 2019 |
143 | HISTOID | A Human iPS Cell-Derived Artificial Skeletal Muscle for Regenerative Medicine, Disease Modelling and Drug Screening | 2018 |
144 | FunHoMic | Deciphering the fungus-host-microbiota interplay to improve the management of fungal infections | 2019 |
145 | GLIOVACC | Augmenting and broadening T-cell responses to glioblastoma - therapeutic vaccine platform based on HCMV expressing NKG2D ligands | 2018 |
146 | REMIND | Targeting pathological synaptic pruning by microglia in neurodegeneration | 2019 |
147 | UPGRADE | Unlocking Precision Gene Therapy | 2019 |
148 | IM2PACT | Investigating Mechanisms and Models Predictive of Accessibility of Therapeutics (IM2PACT) Into The Brain | 2019 |
149 | DaPhNIs | Role of the Maternal Gut Microbiota in Immune Activation at the Maternal-Foetal Interface: Impact on Preeclampsia and Offspring's Immune Development | 2019 |
150 | GEMMA | Genome, Environment, Microbiome & Metabolome in Autism: an integrated multi-omic systems biology approach to identify biomarkers for personalized treatment and primary prevention of Autism Spectr | 2019 |
151 | ArthritisHeal | Establishing the molecular fundamentals of arthritic diseases – a step forward to Heal Arthritis | 2019 |
152 | Epi4MS | Targeting the epigenome: towards a better understanding of disease pathogenesis and novel therapeutic strategies in Multiple Sclerosis | 2019 |
153 | ImmuNiche | Identifying spatial determinants of immune cell fate commitment | 2019 |
154 | ADIMMUNE | Decoding interactions between adipose tissue immune cells, metabolic function, and the intestinal microbiome in obesity | 2019 |
155 | DeCoCt | Knowledge based design of complex synthetic microbial communities for plant protection | 2019 |
156 | RoBE | Study of the role of BANK1 in antibody production and antibody-independent functions of B cells in SLE | 2019 |
157 | SeCRT | Uncover mechanisms of unconventional secretion of tau using functional CRISPR screens - From basic discoveries to neurodegenerative disease therapeutics | 2019 |
158 | TRAIN-HEART | TRAIN-HEART | 2019 |
159 | MagnetoVirology | Diamond Magnetometry: A Versatile Tool for Virology and Medicine | 2019 |
160 | NeuroStemX | In vitro model of Fragile X Syndrome using naïve iPSCs | 2019 |
161 | AstroCOMET | Astrocyte-neuron COmmunication in METabolism and obesity. | 2020 |
162 | PMLingAML | Using PML nuclear body biology to identify potential AML treatment targets | 2020 |
163 | GLYCOMENDO | Non-invasive clinical markers for diagnosis of endometriosis | 2019 |
164 | SynGut | Molecular, morphological, and functional requirements for gastrointestinal serotonin release | 2020 |
165 | CARDIATEAM | CARdiomyopathy in type 2 DIAbetes mellitus | 2019 |
166 | StressOME | Defining and modulating the stress granule proteome as a therapeutic strategy in Amyotrophic Lateral Sclerosis | 2019 |
167 | ROAR | Role of endocycle in Acute Kidney Injury Response and Chronic Kidney Disease development | 2019 |
168 | T-NHL SUPRESSORS | Tumor suppressor pathways counteracting oncogenic immune receptor signaling in T-Cell Lymphoma | 2019 |
169 | FunStructure | Interdependence of functional and structural plasticity in cerebellar climbing fibers in health and disease | 2019 |
170 | IMAGE-IN | Imaging infections: integrated, multiscale visualization of infections and host response | 2020 |
171 | GWAS2FUNC | From GWAS to functional studies: Tackling the complex nature of brain disorders | 2019 |
172 | CELLPHASE_AD | Genetics to understand cellular components of Alzheimer Disease pathogenesis | 2019 |
173 | RECOGNISED | Retinal and cognitive dysfunction in type 2 diabetes: unraveling the common pathways and identification of patients at risk of dementia | 2020 |
174 | InterTAU | Integrative structural biology of pathological tau protein, an appealing therapeutic target for Alzheimer´s disease modifying drugs | 2020 |
175 | STRATIFY | Diagnostic autoantibody assay to stratify bone marrow failure diseases | 2020 |
176 | nbPTMs | A multifaceted platform for exploring nucleotide-based post-translational modifications | 2021 |
177 | CRISPRcombo | Interrogating native CRISPR arrays to achieve scalable combinatorial screens and dissect genetic redundancy | 2020 |
178 | NanoGlia | Understanding the impact of nanoplastics on the development of neurological disorders | 2020 |
179 | SILENT | Silent mutations in cancer | 2020 |
180 | AimingT6SS | Mechanisms of dynamic localization of the bacterial Type 6 secretion system assembly | 2020 |
181 | MyeRIBO | Deconstructing the Translational Control of Myelination by Specialized Ribosomes | 2020 |
182 | STRATEGY-CKD | System omics to unravel the gut-kidney axis in Chronic Kidney Disease. | 2020 |
183 | RARE MAPS | Dynamic proteomic maps of stem cell-derived neurons as a mechanistic discovery pipeline for rare neurological disease | 2020 |
184 | LINKER | Elucidating transcriptional rewiring on hematological malignancies via computational methods | 2020 |
185 | C.A.R.E. OA | Cross-linking Adenosine Receptors - Estrogen receptors for OA treatment | 2021 |
186 | TGF-BTB | Transforming Growth Factor – Bench To Bedside. Towards a better understanding of TGF-β isoform specific signalling in health and disease | 2020 |
187 | DREAM | Dux4-Regulated Expression and Activity by MATR3 | 2020 |
188 | AlzheimersInAction | AlzheimersInAction: A multi-disciplinary approach to determine the cellular and molecular mechanisms underlying the inflammatory response to amyloid-β in Alzheimer’s disease. | 2021 |
189 | LySyT | Understanding the role of lysosomes in the intercellular TNT-mediated spreading of α-synuclein and the impact of lysosomal dysfunction | 2020 |
190 | POMOLIM | Polycystic ovarian syndrome: novel molecular characterization and personalized in vitro maturation protocol. | 2020 |
191 | PRECISMEDLYM | Aggressive T cell Lymphomas, integrated clinical and genomic analysis for a precision medicine. | 2020 |
192 | MAP-AD | A multimodal approach to accelerate drug discovery and development in Alzheimer’s disease | 2021 |
193 | VirIVITES | ARBOVIRUS SKIN INFECTION MODELLING FOR MORE ACCURATE VIRAL PATHOGENESIS | 2020 |
194 | TETCOLON | Dissecting the role of the epigenetic regulator TET2 in colorectal cancer | 2020 |
195 | MUCO-IMMUN | MUCOBIOME-MEDIATED IMMUNE PATHWAYS IN INFLAMMATORY BOWEL DISEASES | 2020 |