Explore the words cloud of the EC GNG metabolism project. It provides you a very rough idea of what is the project "EC GNG metabolism" about.
The following table provides information about the project.
Coordinator |
VIB VZW
Organization address contact info |
Coordinator Country | Belgium [BE] |
Project website | https://www.vibcancer.be/peter-carmeliet |
Total cost | 172˙800 € |
EC max contribution | 172˙800 € (100%) |
Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
Code Call | H2020-MSCA-IF-2015 |
Funding Scheme | MSCA-IF-EF-ST |
Starting year | 2017 |
Duration (year-month-day) | from 2017-01-01 to 2019-02-13 |
Take a look of project's partnership.
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1 | VIB VZW | BE (ZWIJNAARDE - GENT) | coordinator | 172˙800.00 |
Angiogenesis promotes tumor progression and metastasis; unfortunately current anti-angiogenic strategies targeting endothelial growth factors suffer from limited efficacy and toxicity. The host laboratory pioneered the novel concept that blood vessel forming endothelial cells (ECs) reprogram their metabolism to become glucose-addicted and rely on glycolysis to generate ATP required for angiogenesis. Furthermore, to increase biomass production and maintain redox homeostasis, ECs shunt glycolytic intermediates into glycolysis side-pathways. Further ECs diverge from pre-existing blood vessel into avascular tissue, the scarcer external glucose levels will become. Currently, how ECs maintain the generation of glycolytic intermediates under such conditions remains unknown. One possibility is the de-novo synthesis of these intermediates through gluconeogenesis (GNG).
To date, nothing is known about GNG metabolism in ECs, which underscores the novelty of my proposal. GNG is particularly interesting since preliminary findings indicate that ECs express all enzymes involved in GNG, and impairing this pathway decreases EC proliferation and sprouting. Therefore, through a multi-angled approach, I will unravel the role of GNG in ECs and uncover its contribution to blood vessel sprouting both in normal and pathological angiogenesis.
Ultimately this project will explore whether blocking GNG may inhibit pathological angiogenesis (e.g. cancer) and translate my findings into therapeutic strategies.
year | authors and title | journal | last update |
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2018 |
Guy Eelen, Pauline de Zeeuw, Lucas Treps, Ulrike Harjes, Brian W. Wong, Peter Carmeliet Endothelial Cell Metabolism published pages: 3-58, ISSN: 0031-9333, DOI: 10.1152/physrev.00001.2017 |
Physiological Reviews 98/1 | 2019-08-08 |
2018 |
Joanna Kalucka, Laura Bierhansl, Nadine Vasconcelos Conchinha, Rindert Missiaen, Ilaria Elia, Ulrike Brüning, Samantha Scheinok, Lucas Treps, Anna Rita Cantelmo, Charlotte Dubois, Pauline de Zeeuw, Jermaine Goveia, Annalisa Zecchin, Federico Taverna, Francisco Morales-Rodriguez, Aleksandra Brajic, Lena-Christin Conradi, Sandra Schoors, Ulrike Harjes, Kim Vriens, Gregor-Alexander Pilz, Rongyuan Chen, Richard Cubbon, Bernard Thienpont, Bert Cruys, Brian W. Wong, Bart Ghesquière, Mieke Dewerchin, Katrien De Bock, Xavier Sagaert, Sebastian Jessberger, Elizabeth A.V. Jones, Bernard Gallez, Diether Lambrechts, Massimiliano Mazzone, Guy Eelen, Xuri Li, Sarah-Maria Fendt, Peter Carmeliet Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis published pages: 881-894.e13, ISSN: 1550-4131, DOI: 10.1016/j.cmet.2018.07.016 |
Cell Metabolism 28/6 | 2019-08-08 |
2018 |
Shawez Khan, Federico Taverna, Katerina Rohlenova, Lucas Treps, Vincent Geldhof, Laura de Rooij, Liliana Sokol, Andreas Pircher, Lena-Christin Conradi, Joanna Kalucka, Luc Schoonjans, Guy Eelen, Mieke Dewerchin, Tobias Karakach, Xuri Li, Jermaine Goveia, Peter Carmeliet EndoDB: a database of endothelial cell transcriptomics data published pages: D736-D744, ISSN: 0305-1048, DOI: 10.1093/nar/gky997 |
Nucleic Acids Research 47/D1 | 2019-08-08 |
2017 |
Brian W Wong, Elke Marsch, Lucas Treps, Myriam Baes, Peter Carmeliet Endothelial cell metabolism in health and disease: impact of hypoxia published pages: 2187-2203, ISSN: 0261-4189, DOI: 10.15252/embj.201696150 |
The EMBO Journal 36/15 | 2019-08-08 |
2018 |
Lucas Treps EnLIGHTenment of tumor vessel normalization and immunotherapy in glioblastoma published pages: 3-6, ISSN: 0022-3417, DOI: 10.1002/path.5103 |
The Journal of Pathology 246/1 | 2019-08-08 |
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