#	Pagina
attuale pagina	/open-h2020/projects/202551/index.html

Opendata, web and dolomites

Age Asymmetry SIGNED

Age-Selective Segregation of Organelles

Total Cost €

EC-Contrib. €

Partnership

Views

Age Asymmetry project word cloud

Explore the words cloud of the Age Asymmetry project. It provides you a very rough idea of what is the project "Age Asymmetry" about.

renewed selective slowing organelle compromise phenomenon material discoveries enrich concentrated young accumulation analogous asymmetrically decline types subcellular cellular constantly differentiating chronological strategy tissue compartments first few chronologically possibilities asymmetric segregation hypothesize daughter proxy mechanisms protein harmful tissues renewal discovered mammalian relevance aging cell regeneration age human our cells analyze sustained yeast time functional mainly vivo stem epithelium differ accumulate recognize divide sort underlying mitochondria secure damage mammary division tools maintenance property mechanism apportion induction

Project "Age Asymmetry" data sheet

The following table provides information about the project.

Coordinator	HELSINGIN YLIOPISTO Organization address address: YLIOPISTONKATU 3 city: HELSINGIN YLIOPISTO postcode: 14 website: www.helsinki.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Finland [FI]
Total cost	1˙500˙000 €
EC max contribution	1˙500˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2015-STG
Funding Scheme	ERC-STG
Starting year	2016
Duration (year-month-day)	from 2016-05-01 to 2021-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	HELSINGIN YLIOPISTO HELSINGIN YLIOPISTO Organization address address: YLIOPISTONKATU 3 city: HELSINGIN YLIOPISTO postcode: 14 website: www.helsinki.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (HELSINGIN YLIOPISTO)	coordinator	1˙500˙000.00

Map

Project objective

Our tissues are constantly renewed by stem cells. Over time, stem cells accumulate cellular damage that will compromise renewal and results in aging. As stem cells can divide asymmetrically, segregation of harmful factors to the differentiating daughter cell could be one possible mechanism for slowing damage accumulation in the stem cell. However, current evidence for such mechanisms comes mainly from analogous findings in yeast, and studies have concentrated only on few types of cellular damage. I hypothesize that the chronological age of a subcellular component is a proxy for all the damage it has sustained. In order to secure regeneration, mammalian stem cells may therefore specifically sort old cellular material asymmetrically. To study this, I have developed a novel strategy and tools to address the age-selective segregation of any protein in stem cell division. Using this approach, I have already discovered that stem-like cells of the human mammary epithelium indeed apportion chronologically old mitochondria asymmetrically in cell division, and enrich old mitochondria to the differentiating daughter cell. We will investigate the mechanisms underlying this novel phenomenon, and its relevance for mammalian aging. We will first identify how old and young mitochondria differ, and how stem cells recognize them to facilitate the asymmetric segregation. Next, we will analyze the extent of asymmetric age-selective segregation by targeting several other subcellular compartments in a stem cell division. Finally, we will determine whether the discovered age-selective segregation is a general property of stem cell in vivo, and it's functional relevance for maintenance of stem cells and tissue regeneration. Our discoveries may open new possibilities to target aging associated functional decline by induction of asymmetric age-selective organelle segregation.

Publications

List of publications.
year	authors and title	journal	last update
2019	Nalle Pentinmikko, Sharif Iqbal, Miyeko Mana, Simon Andersson, Armand B. Cognetta III, Radu M. Suciu, Jatin Roper, Kalle LuopajÃ¤rvi, Eino Markelin, Swetha Gopalakrishnan, Olli-Pekka Smolander, Santiago Naranjo, Tuure Saarinen, Anne Juuti, Kirsi PietilÃ¤inen, Petri Auvinen, Ari RistimÃ¤ki, Nitin Gupta, Tuomas Tammela, Tyler Jacks, David M. Sabatini, Benjamin F. Cravatt, Ã–mer H. Yilmaz, and Pekka Paneth cell produced Notum attenuates regeneration of aged intestinal epithelium published pages: , ISSN: 0028-0836, DOI: 10.1038/s41586-019-1383-0	Nature	2019-09-04
2018	Maria M. Mihaylova, Chia-Wei Cheng, Amanda Q. Cao, Surya Tripathi, Miyeko D. Mana, Khristian E. Bauer-Rowe, Monther Abu-Remaileh, Laura Clavain, Aysegul Erdemir, Caroline A. Lewis, Elizaveta Freinkman, Audrey S. Dickey, Albert R. La Spada, Yanmei Huang, George W. Bell, Vikram Deshpande, Peter Carmeliet, Pekka Katajisto, David M. Sabatini, Ã–mer H. Yilmaz Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging published pages: 769-778.e4, ISSN: 1934-5909, DOI: 10.1016/j.stem.2018.04.001	Cell Stem Cell 22/5	2019-09-04

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "AGE ASYMMETRY" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "AGE ASYMMETRY" are provided by the European Opendata Portal: CORDIS opendata.