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CAMERA SIGNED

Characterizing Adaptation and Migration Events with Modern and Ancient Genomes

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

CAMERA project word cloud

Explore the words cloud of the CAMERA project. It provides you a very rough idea of what is the project "CAMERA" about.

temporal admixture on technically theory estimate genomics data serial dates of mode benefit generating human physiology american contact era 14c peopling methodological molecular collected entered dna question acting insights examples methodology genome evolutionary sequence generate selective evolution collect ancient altitude basis respectively polynesian questions answer background south resolution relevance experimental population combine datasets gain stress tools colonization modern timing sweep adaptive americas fundamental illnesses genetic epidemiology performing manner date ecological intensity tempo statistical locus humans utilizing textbook models time world combining event undergoing genomic medical amount

Project "CAMERA" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAET BERN Organization address address: HOCHSCHULSTRASSE 6 city: BERN postcode: 3012 website: http://www.unibe.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Switzerland [CH]
Project website	http://wp.unil.ch/egg
Total cost	1˙498˙478 €
EC max contribution	1˙498˙478 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2015-STG
Funding Scheme	ERC-STG
Starting year	2016
Duration (year-month-day)	from 2016-08-01 to 2021-07-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAET BERN UNIVERSITAET BERN Organization address address: HOCHSCHULSTRASSE 6 city: BERN postcode: 3012 website: http://www.unibe.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BERN)	coordinator	1˙498˙478.00

Map

Project objective

BACKGROUND Ancient DNA research has recently entered the genomics era. Performing “ancient population genomics” is now technically possible. Utilizing the temporal aspect of this new data, we can address fundamental evolutionary questions such as the amount of selection acting on the genome or the mode and tempo of the colonization of the world. AIMS The overall goal of the proposed research is to (i) generate and analyse data to answer two long standing questions in human evolution: understanding the molecular basis of human adaptation to high altitude and investigating the timing of the Polynesian-South American contact, (ii) develop statistical approaches that combine ancient and modern genetic data to estimate the timing and the intensity of a selective sweep and an admixture event. METHODOLOGY Application: We will collect, date and DNA sequence human remains. Combining the ancient genetic data, 14C dates with existing modern genomic data will allow us to increase the resolution as to the timing of the adaptive and the admixture event, respectively, while generating unique datasets. Theory: We will build on existing methods based on one-locus classical population genetic models to develop tools to analyse whole genome time serial data. RELEVANCE Ecological: The results will address the fundamental question of how much of the human genome is undergoing selection, better characterize one of the textbook examples of adaptation in humans and contribute to our understanding of the peopling of the Americas. Medical: We will gain insights into the fundamental stress physiology experienced at high altitude and therefore into altitude-related illnesses. Methodological: The methods developed in this project will not only benefit the growing field of ancient genomics but also other fields where data is collected in a temporal manner, such as experimental evolution and epidemiology

Publications

List of publications.
year	authors and title	journal	last update
2018	J. VÃctor Moreno-Mayar, Lasse Vinner, Peter de Barros Damgaard, Constanza de la Fuente, Jeffrey Chan, Jeffrey P. Spence, Morten E. Allentoft, Tharsika Vimala, Fernando Racimo, Thomaz Pinotti, Simon Rasmussen, Ashot Margaryan, Miren Iraeta Orbegozo, Dorothea Mylopotamitaki, Matthew Wooller, Clement Bataille, Lorena Becerra-Valdivia, David Chivall, Daniel Comeskey, Thibaut DeviÃ¨se, Donald K. Grays Early human dispersals within the Americas published pages: eaav2621, ISSN: 0036-8075, DOI: 10.1126/science.aav2621	Science 362/6419	2019-08-05
2018	Saskia Wutke, Edson Sandoval-Castellanos, Norbert Benecke, Hans-JÃ¼rgen DÃ¶hle, Susanne Friederich, Javier Gonzalez, Michael Hofreiter, Lembi LÃµugas, Ola Magnell, Anna-Sapfo Malaspinas, Arturo Morales-MuÃ±iz, Ludovic Orlando, Monika Reissmann, Alexandra Trinks, Arne Ludwig Decline of genetic diversity in ancient domestic stallions in Europe published pages: eaap9691, ISSN: 2375-2548, DOI: 10.1126/sciadv.aap9691	Science Advances 4/4	2019-08-05
2018	Diana I. Cruz-DÃ¡valos, MarÃa A. Nieves-ColÃ³n, Alexandra Sockell, G. David Poznik, Hannes Schroeder, Anne C. Stone, Carlos D. Bustamante, Anna-Sapfo Malaspinas, MarÃa C. Ãvila-Arcos In-solution Y-chromosome capture-enrichment on ancient DNA libraries published pages: , ISSN: 1471-2164, DOI: 10.1186/s12864-018-4945-x	BMC Genomics 19/1	2019-08-05
2018	Constanza de la Fuente, MarÃa C. Ãvila-Arcos, Jacqueline Galimany, Meredith L. Carpenter, Julian R. Homburger, Alejandro Blanco, Paloma Contreras, Diana Cruz DÃ¡valos, Omar Reyes, Manuel San Roman, AndrÃ©s Moreno-Estrada, Paula F. Campos, Celeste Eng, Scott Huntsman, Esteban G. Burchard, Anna-Sapfo Malaspinas, Carlos D. Bustamante, Eske Willerslev, Elena Llop, Ricardo A. Verdugo, Mauricio Moraga Genomic insights into the origin and diversification of late maritime hunter-gatherers from the Chilean Patagonia published pages: E4006-E4012, ISSN: 0027-8424, DOI: 10.1073/pnas.1715688115	Proceedings of the National Academy of Sciences 115/17	2019-08-05
2018	Marcia S. Ponce de LeÃ³n, Toetik Koesbardiati, John David Weissmann, Marco Milella, Carlos S. Reyna-Blanco, Gen Suwa, Osamu Kondo, Anna-Sapfo Malaspinas, Tim D. White, Christoph P. E. Zollikofer Human bony labyrinth is an indicator of population history and dispersal from Africa published pages: 4128-4133, ISSN: 0027-8424, DOI: 10.1073/pnas.1717873115	Proceedings of the National Academy of Sciences 115/16	2019-08-05
2018	Joanne L. Wright, Sally Wasef, Tim H. Heupink, Michael C. Westaway, Simon Rasmussen, Colin Pardoe, Gudju Gudju Fourmile, Michael Young, Trish Johnson, Joan Slade, Roy Kennedy, Patsy Winch, Mary Pappin, Tapij Wales, William â€œBadgerâ€ Bates, Sharnie Hamilton, Neville Whyman, Sheila van Holst Pellekaan, Peter J. McAllister, Paul S.C. TaÃ§on, Darren Curnoe, Ruiqiang Li, Craig Millar, Sankar Subrama Ancient nuclear genomes enable repatriation of Indigenous human remains published pages: eaau5064, ISSN: 2375-2548, DOI: 10.1126/sciadv.aau5064	Science Advances 4/12	2019-08-05
2018	Hugh McColl, Fernando Racimo, Lasse Vinner, Fabrice Demeter, Takashi Gakuhari, J. VÃctor Moreno-Mayar, George van Driem, Uffe Gram Wilken, Andaine Seguin-Orlando, Constanza de la Fuente Castro, Sally Wasef, Rasmi Shoocongdej, Viengkeo Souksavatdy, Thongsa Sayavongkhamdy, Mohd Mokhtar Saidin, Morten E. Allentoft, Takehiro Sato, Anna-Sapfo Malaspinas, Farhang A. Aghakhanian, Thorfinn Korneliussen, The prehistoric peopling of Southeast Asia published pages: 88-92, ISSN: 0036-8075, DOI: 10.1126/science.aat3628	Science 361/6397	2019-08-05

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The information about "CAMERA" are provided by the European Opendata Portal: CORDIS opendata.