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AD-gut SIGNED

Alzheimer Disease - gut connection

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

AD-gut project word cloud

Explore the words cloud of the AD-gut project. It provides you a very rough idea of what is the project "AD-gut" about.

discovered probiotic accomplishment successful harvested baseline cerebral mice mouse western pathology prevention nor technologies conventionally microbial risk world diagnostics date slow disease strategies survival amyloid wild contrast personalized efficient medicine gf strategy brain disorder derive involvement revealed microbiome diagnosis natural indirect modulation encapsulation alzheimer microbiota samples road strains transplantation ultimately 16s dementia germ free bacterial marketing guarantee setting gut designing optimizing sequencing onset cocktails remarkable preventive altogether cure intestinal ad model opposed therapeutic halt rrna shift fecal paves neurodegenerative healthy standard diagnostic raised beta horizons biomedical drastic dramatically

Project "AD-gut" data sheet

The following table provides information about the project.

Coordinator	ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Organization address address: BATIMENT CE 3316 STATION 1 city: LAUSANNE postcode: 1015 website: www.epfl.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Switzerland [CH]
Project website	http://adgut.eu/
Total cost	7˙686˙620 €
EC max contribution	5˙092˙886 € (66%)
Programme	1. H2020-EU.2.1.3. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials)
Code Call	H2020-NMP-2015-two-stage
Funding Scheme	RIA
Starting year	2016
Duration (year-month-day)	from 2016-04-01 to 2020-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Organization address address: BATIMENT CE 3316 STATION 1 city: LAUSANNE postcode: 1015 website: www.epfl.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (LAUSANNE)	coordinator	0.00
2	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: MUENCHEN postcode: 80539 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	1˙551˙003.00
3	KATHOLIEKE UNIVERSITEIT LEUVEN KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: OUDE MARKT 13 city: LEUVEN postcode: 3000 website: www.kuleuven.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LEUVEN)	participant	1˙499˙810.00
4	LUNDS UNIVERSITET LUNDS UNIVERSITET Organization address address: Paradisgatan 5c city: LUND postcode: 22100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (LUND)	participant	1˙287˙403.00
5	VIB VZW VIB VZW Organization address address: RIJVISSCHESTRAAT 120 city: ZWIJNAARDE - GENT postcode: 9052 website: www.vib.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (ZWIJNAARDE - GENT)	participant	754˙668.00
6	UNIVERSITAET BERN UNIVERSITAET BERN Organization address address: HOCHSCHULSTRASSE 6 city: BERN postcode: 3012 website: http://www.unibe.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BERN)	participant	0.00

Map

Project objective

Alzheimer’s disease (AD) is the leading cause of dementia in the Western world and to date no cure nor any preventive strategy are available for this neurodegenerative disorder. Bacterial 16S rRNA sequencing from fecal samples revealed a remarkable shift in the gut microbiota of conventionally-raised AD mice compared to healthy, wild-type mice. Based on these findings, we generated germ-free Alzheimer (GF-AD) mouse model and discovered a drastic reduction of cerebral Aβ amyloid pathology when compared to control AD mice with natural intestinal microbiota. In contrast, fecal transplantation of GF-AD with harvested microbiota from conventionally-raised AD mice dramatically increased cerebral Aβ pathology.

Altogether, these results strongly support a microbial involvement in the development of AD and show how gut microbiome modulation can slow down or halt its onset. This paves the road to new indirect diagnostic and therapeutic approaches for AD prevention, based on gut microbiota modulation through probiotic cocktails.

Based on these findings, the present proposal aims at designing and optimizing an efficient encapsulation strategy to guarantee the survival and the delivery of probiotic strains in the gut as opposed to standard strategies targeting directly the brain. A successful accomplishment of this goal will also allow to derive AD risk factors and to establish an objective baseline setting for AD diagnosis. Ultimately, the present project will open new horizons in biomedical diagnostics and personalized medicine through the marketing of these technologies and therapeutic concepts.

Deliverables

List of deliverables.
Production of m-MOOCs	Websites, patent fillings, videos etc.	2019-08-29 13:02:42
Workshop	Websites, patent fillings, videos etc.	2019-08-29 13:02:41
Creation of website	Websites, patent fillings, videos etc.	2019-08-29 13:02:41
Mid-term press release	Websites, patent fillings, videos etc.	2019-08-29 13:02:42

Take a look to the deliverables list in detail: detailed list of AD-gut deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Christiane Seidler, Maksymilian Marek Zegota, Marco Raabe, Seah Ling Kuan, David Y. W. Ng, Tanja Weil Dynamic Core-Shell Bioconjugates for Targeted Protein Delivery and Release published pages: 3474-3479, ISSN: 1861-4728, DOI: 10.1002/asia.201800843	Chemistry - An Asian Journal 13/22	2019-06-06
2019	M. Pieszka, A. M. Sobota, J. GaÄanin, T. Weil, D. Y. W. Ng Orthogonally Stimulated Assembly/Disassembly of Depsiâ€peptides by Rational Chemical Design published pages: , ISSN: 1439-7633, DOI: 10.1002/cbic.201800781m	ChemBioChem	2019-05-15
2019	Wang, Y.; Horlamus, F.; Henkel, M.; Kovacic, F.; Schlaefle, S.; Hausmann, R.; Wittgens, A.; Rosenau, F. Growth of engineered Pseudomonas putida KT2440 on glucose, xylose, and arabinose: Hemicellulose hydrolysates and their major sugars as sustainable carbon sources published pages: , ISSN: 1757-1693, DOI: 10.1111/gcbb.12590	GCB Bioenergy 11	2019-05-15
2018	K. Dâ€™hoe, S. Vet, K. Faust, F. Moens, G. Falony, D. Gonze, V. Llorens-Rico, L. Gelens, J. Danckaert, L. De Vuyst and J. Raes Integrated culturing, modeling and transcriptomics uncovers complex interactions and emergent behavior in a three-species synthetic gut community published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.37090	eLife	2019-05-15
2017	T. Harach, N. Marungruang, N. Duthilleul, V. Cheatham, K. D. Mc Coy, G. Frisoni, J. J. Neher, F. FÃ¥k, M. Jucker, T. Lasser, T. Bolmont Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota published pages: , ISSN: 2045-2322, DOI: 10.1038/srep41802	Scientific Reports 7/1	2019-05-15
2018	G. R. B. Huys, J. Raes Go with the flow or solitary confinement: a look inside the single-cell toolbox for isolation of rare and uncultured microbes published pages: 1/8, ISSN: 1369-5274, DOI: 10.1016/j.mib.2018.05.002	Current Opinion in Microbiology Vol. 44	2019-05-15
2019	GaÄanin, J.; Hedrich, J.; Sieste, S.; Glasser, G.; Lieberwirth, I.; Schilling, C.; Fischer, S.; Barth, H.; Knoell, B.; Synatschke, C.; Weil, T. Autonomous Ultrafast Self-Healing Hydrogels by pH-Responsive Functional Nanofiber Gelators as Cell Matrices published pages: , ISSN: 0935-9648, DOI: 10.1002/adma.201805044	Advanced Materials 31	2019-05-15

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