TRIGEM
Unlocking Triterpenoid Structural Diversity and Bioactivity through Genome Mining
Total Cost €
0EC-Contrib. €
0Partnership
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Explore the words cloud of the TRIGEM project. It provides you a very rough idea of what is the project "TRIGEM" about.
Project "TRIGEM" data sheet
The following table provides information about the project.
| Coordinator |
JOHN INNES CENTRE
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Project website | https://www.jic.ac.uk/directory/anne-osbourn/ |
| Total cost | 183˙454 € |
| EC max contribution | 183˙454 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2015 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-10-01 to 2018-09-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | JOHN INNES CENTRE | UK (NORWICH) | coordinator | 183˙454.00 |
Map
Project objective
The triterpenoids are one of the largest and most structurally complex plant natural products. They are widespread in the Plant Kingdom and have a huge array of structures and numerous associated biological activities. They have important roles in plant defence and signalling. They are also exploited by humans as food supplements, drugs and cosmetics across various sectors. In the past the discovery and production of triterpenoids has relied mainly on isolation from extracts of natural sources and subsequent structural elucidation and chemical modification. These methods suffer from low efficiency and high cost, and are not environmentally sustainable. We herein propose a greener and more sustainable but as yet largely unexplored synthetic biology-based approach that involves genome mining and metabolic engineering to synthesise structural variants of triterpenoids, with a view to discovering novel structures with biological activities for various application prospects in a rapid manner. This project will also shed new light on the biosynthetic pathways of triterpenoids by uncovering new genes and enzymes and will open up opportunities for production of important triterpenoids via further metabolic manipulations in plant or microbial ‘green factories’.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
Ancheng C. Huang, Young J. Hong, Andrew D. Bond, Dean J. Tantillo, Anne Osbourn Diverged Plant Terpene Synthases Reroute the Carbocation Cyclization Path towards the Formation of Unprecedented 6/11/5 and 6/6/7/5 Sesterterpene Scaffolds published pages: 1291-1295, ISSN: 1433-7851, DOI: 10.1002/anie.201711444 |
Angewandte Chemie International Edition 57/5 | 2019-06-13 |
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