Opendata, web and dolomites
  1. home
  2. trasparenza
  3. open h2020
  4. fluorodendrinostic

FluoroDendriNostic

Combined fluorinated polymer and poly-L-lysine dendrimer as new potential contrast agents for magnetic resonance imaging 19F

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0
 Outcomes and results

 FluoroDendriNostic project word cloud

Explore the words cloud of the FluoroDendriNostic project. It provides you a very rough idea of what is the project "FluoroDendriNostic" about.

vitro    poly    early    amphiphilic    variety    purely    supramolecular    complementary    alternative    spectroscopic    fluorinated    noise    good    cancer    expertise    copolymer    structure    created    dendritic    immunogenic    morphologies    ultimate    afford    self    attractive    lysine    magnetic    biocompatible    destructive    amphiphiles    platform    dendrigrafts    compounds    nanoparticles    blocks    series    signature    micelles    fluoropolymer    invasive    polymerization    originally    contrast    fluoropolymers    organization    synthesize    vivo    functionalization    host    materials    19f    signal    vesicles    assembly    powerful    dgls    mri    polymers    combining    polymer    phenomena    techniques    resonance    arborescent    diseases    coatings    agents    suitable    drug    cylinders    tumors    technique    hydrogenated    biomedical    diagnosis    dendrimer    fundamental    regular    biosynthetic    of    shown    team    researcher    bearing    copolymers    nanoreactors    structures    imaging    ratio    hydrophobic    solvent    aggregates    molecular   

Project "FluoroDendriNostic" data sheet

The following table provides information about the project.

Coordinator		 THE UNIVERSITY OF BIRMINGHAM 

Organization address
address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT
website: www.bham.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country United Kingdom [UK]
 Project website https://www.oreillygrouplab.com/
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2018-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) coordinator 38˙219.00
2    THE UNIVERSITY OF WARWICK UK (COVENTRY) participant 145˙235.00

Map

 Project objective

Early diagnosis of diseases, including tumors, is the ultimate goal of biomedical imaging. Magnetic resonance imaging (MRI) is a technique for non-destructive and non-invasive diagnosis of a number of diseases including cancer. Recently, contrast agents bearing 19F have been introduced as an attractive alternative to purely hydrogenated compounds, because of their high signal to noise ratio as result of their unique spectroscopic signature. This project aims to design, synthesize and characterize a series of novel fluorinated amphiphilic structures based on a fluoropolymer and a dendrimer (so called DendriGrafts, DGLs) based on poly-L-lysine. DGLs are a new type of arborescent biosynthetic polymer of regular and controlled structure. They have been shown to be biocompatible and non-immunogenic. It proposed that these DGLs to have potential as a powerful platform for the functionalization of hydrophobic polymers and to afford fluoropolymers for applications in 19F MRI. Combining DGLs and fluoropolymers in a good solvent for one of the blocks, is proposed to enable self-assembly of the amphiphiles into a variety of morphologies and molecular aggregates (including micelles, vesicles or cylinders). Increasing attention has been given to this type of supramolecular organization and to their potential use in applications such as coatings, drug delivery systems, nanoparticles or nanoreactors. Thus, this project will not only study the fundamental phenomena of self-organization of these novel copolymers but will also result in new materials suitable for application as novel agents in 19F MRI. Combining the complementary expertise from the Experienced Researcher in dendritic polymers, the host team in polymerization techniques and polymer self-assembly, a series of novel copolymer systems will be originally created in this project and finally studied by in vitro and in vivo.

 Publications

year authors and title journal last update
List of publications.
2019 Couturaud Benoit; Panagiotis G. Georgiou; Spyridon Varlas; Joseph R. Jones; Maria C. Arno; Jeffrey C. Foster; Rachel K. O\'Reilly
Poly(Pentafluorophenyl Methacrylate)-Based Nano-Objects Developed by Photo-PISA as Scaffolds for Post-Polymerization Functionalization
published pages: , ISSN: , DOI: 10.5281/zenodo.2545669 		2019-05-25
2018 Jeffrey C. Foster; Spyridon Varlas; Benoit Couturaud; Joseph R. Jones; Robert Keogh; Robert T. Mathers; Rachel K. O\'Reilly
Predicting Monomers for Use in Polymerization-Induced Self-Assembly
published pages: , ISSN: , DOI: 10.5281/zenodo.2545666 		2019-05-25

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "FLUORODENDRINOSTIC" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "FLUORODENDRINOSTIC" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

RipGEESE (2020)

Identifying the ripples of gene regulation evolution in the evolution of gene sequences to determine when animal nervous systems evolved

Read More  

CIRICC (2019)

Complicity: Individual Responsibility in Collective Contexts

Read More  

NarrowbandSSL (2019)

Development of Narrow Band Blue and Red Emitting Macromolecules for Solution-Processed Solid State Lighting Devices

Read More