The Translational Research Network for Prostate Cancer (TransPot) program adopts an innovative, multidisciplinary approach, providing highly sought-after, effective solutions for incurable prostate cancer (PC).
The TransPot scientific objective is to obtain an unmatched depth of molecular, mechanistic and informatics systems-level disease understanding in order to improve the prognosis and treatment of lethal PC, aimed to (i) provide important insights into molecular mechanisms driving treatment resistant PC including castrate-resistant PC (CRPC), (ii) identify novel therapeutic targets, (iii) develop and validate predictive models for disease progression, prognosis and responsiveness to current and novel (co-)treatment options, and (iv) provide superior, clinically relevant tools and biomarker signatures for personalising and optimising CRPC therapy.
Our research program is built on network-wide, state-of-the-art cancer biology-based mechanistic research integrated with a systems medicine approach:
1. Cancer biology-based mechanistic research incorporating a comprehensive range of model systems incorporating unique, pre-clinical and clinical resources and distinct phenotypic high content screen platforms.
2. A systems medicine approach with mathematical modelling to develop novel predictive/prognostic tools.
3. Centres of excellence in surgery, oncology and clinical trials, comprising clinical infrastructure and essential resources whereby candidate therapeutic targets and predictive/prognostic tools can be comprehensively evaluated, including accessing bio-repository resources.
We will train young scientists to apply multiple ‘omics’ technologies and approaches in model systems and systems biology to answer important clinically-relevant questions. Advances achieved will facilitate personalized targeted-medicine in treating lethal PC, and will impact beyond the scientific community by improving the well-being of advanced PC patients.
Deliverables
List of deliverables.
ESRs Recruitment
Other
2020-04-15 09:09:56
TransPot website and social media presence built, maintained and operated
Marouane Kdadra, Sebastian Höckner, Hing Leung, Werner Kremer, Eric Schiffer Metabolomics Biomarkers of Prostate Cancer: A Systematic Review published pages: 21, ISSN: 2075-4418, DOI: 10.3390/diagnostics9010021
Diagnostics 9/1
2020-04-15
2018
S. Umbreen, R.E. Steele, N. Poulose, S. Mcdade, N. Mccabe, I.G. Mills Approaches to enrich for androgen receptor binding sites in low-cell number samples published pages: e2499, ISSN: 1569-9056, DOI: 10.1016/s1569-9056(18)32982-8
European Urology Supplements 17/10
2020-04-15
2018
P. Singh, C.N. Robson, R. Heer In vitro prostate differentiation of induced pluripotent stem cells and organoid generation using seminal vesicle mesenchyme published pages: e2557, ISSN: 1569-9056, DOI: 10.1016/s1569-9056(18)33034-3
European Urology Supplements 17/10
2020-04-15
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "TRANSPOT" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "TRANSPOT" are provided by the European Opendata Portal: CORDIS opendata.
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