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PhotoMedMet SIGNED

Towards Novel Inert (Photo-)toxic Ru(II) Polypyridyl Complexes

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

PhotoMedMet project word cloud

Explore the words cloud of the PhotoMedMet project. It provides you a very rough idea of what is the project "PhotoMedMet" about.

vivo unfortunately double photodynamic frequently selectivity attributed photosensitizers pdt excite seminal 1950s impressive search chemotherapy vector coupled newly drug think excitation couple anticancer interesting prodrug shulman lack drugs relatively intend cancer modality tpa specificity limit pe kill therapy reasonable purposes cell polypyridyl last fight treatment invasive drawbacks metal absorption shown grant activation tackle antibodies nonetheless complexes followed inert least ru encountered photon neurotoxicity peptides interestingly dwyer simultaneous presented 1960s vitro bacteria compounds candidates pss revival alternative proven additional 2pe photo

Project "PhotoMedMet" data sheet

The following table provides information about the project.

Coordinator	ECOLE NATIONALE SUPERIEURE DE CHIMIE DE PARIS There are not information about this coordinator. Please contact Fabio for more information, thanks.
Coordinator Country	France [FR]
Project website	https://www.gassergroup.com
Total cost	662˙015 €
EC max contribution	662˙015 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2015-CoG
Funding Scheme	ERC-COG
Starting year	2016
Duration (year-month-day)	from 2016-10-01 to 2021-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ECOLE NATIONALE SUPERIEURE DE CHIMIE DE PARIS ECOLE NATIONALE SUPERIEURE DE CHIMIE DE PARIS Organization address address: 11 RUE PIERRE ET MARIE CURIE city: PARIS CEDEX 05 postcode: 75231 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS CEDEX 05)	coordinator	662˙015.00
2	ECOLE NATIONALE SUPERIEURE DE CHIMIE DE PARIS ECOLE NATIONALE SUPERIEURE DE CHIMIE DE PARIS Organization address address: RUE PIERRE ET MARIE CURIE 11 city: PARIS postcode: 75005 website: www.enscp.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	coordinator	0.00

Map

Project objective

In this grant application, I propose to investigate in-depth the potential of novel inert Ru(II) polypyridyl complexes as novel anticancer drug candidates. Such compounds were investigated by Dwyer and Shulman in 1950s and 1960s both in vitro and in vivo with relatively promising results. This impressive seminal work was unfortunately not followed-up. This lack of additional studies was recently attributed, at least in part, to the observed neurotoxicity of the complexes. Nonetheless, over the last years, there has been a revival of important in vitro studies of such inert Ru(II) polypyridyl complexes for anticancer purposes. However, without further in vivo studies, it is reasonable to think that similar neurotoxicity to that observed by Dwyer and Shulman could be encountered. In order to tackle these (potential) drawbacks, I propose to use a prodrug approach. Furthermore, I also intend to investigate the potential of inert Ru(II) polypyridyl complexes as photosensitizers (PSs) in photodynamic therapy (PDT). In the search for an alternative approach to chemotherapy, PDT has proven to be a promising, effective and non-invasive treatment modality. Importantly, in order to increase even further the potential of the PSs presented in this project, I propose to also excite them via simultaneous two-photon absorption (TPA) in the so-called two-photon excitation PDT (2 PE-PDT). Importantly, the newly Ru(II)-based PSs will be coupled to cancer cell-specific peptides or antibodies. This double selectivity (targeting vector and photo-activation) should limit the frequently encountered side-effects of (metal-based) anticancer drugs. Another important aim of this second part of this project will be the use of the Ru(II)-based PSs to kill bacteria. Interestingly, PDT has been recently shown to be an interesting alternative to fight bacteria. I therefore intend to couple Ru(II)-based (2PE )PSs to bacteria-specific peptides to bring bacteria specificity.

Publications

List of publications.
year	authors and title	journal	last update
2020	Johannes Karges, Gilles Gasser Synthesis, Characterisation and Biological Evaluation of Ï€-Extended Fe(II) Bipyridine Complexes as Potential Photosensitizers for Photodynamic Therapy published pages: 119196, ISSN: 0020-1693, DOI: 10.1016/j.ica.2019.119196	Inorganica Chimica Acta 499	2019-11-22
2019	Elise Villemin, Yih Ching Ong, Christophe M. Thomas, Gilles Gasser Polymer encapsulation of ruthenium complexes for biological and medicinal applications published pages: 261-282, ISSN: 2397-3358, DOI: 10.1038/s41570-019-0088-0	Nature Reviews Chemistry 3/4	2019-11-22
2019	Marta Jakubaszek, Jeremie Rossier, Johannes Karges, Joachim Delasoie, Bruno Goud, Gilles Gasser, Fabio Zobi Evaluation of the Potential of Cobalamin Derivatives Bearing Ru(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy published pages: , ISSN: 0018-019X, DOI: 10.1002/hlca.201900104	Helvetica Chimica Acta 102/7	2019-11-22
2019	Johannes Karges, Olivier Blacque, Hui Chao, Gilles Gasser Polymeric Bis(dipyrrinato) Zinc(II) Nanoparticles as Selective Imaging Probes for Lysosomes of Cancer Cells published pages: 12422-12432, ISSN: 0020-1669, DOI: 10.1021/acs.inorgchem.9b02019	Inorganic Chemistry 58/18	2019-11-22
2019	Johannes Karges, Uttara Basu, Olivier Blacque, Hui Chao, Gilles Gasser Polymeric Encapsulation of Novel Homoleptic Bis(dipyrrinato) Zinc(II) Complexes with Long Lifetimes for Applications as Photodynamic Therapy Photosensitisers published pages: 14334-14340, ISSN: 1433-7851, DOI: 10.1002/anie.201907856	Angewandte Chemie International Edition 58/40	2019-11-22
2019	Huaiyi Huang, Samya Banerjee, Kangqiang Qiu, Pingyu Zhang, Olivier Blacque, Thomas Malcomson, Martin J. Paterson, Guy J. Clarkson, Michael Staniforth, Vasilios G. Stavros, Gilles Gasser, Hui Chao, Peter J. Sadler Targeted photoredox catalysis in cancer cells published pages: 1041-1048, ISSN: 1755-4330, DOI: 10.1038/s41557-019-0328-4	Nature Chemistry 11/11	2019-11-22
2019	Johannes Karges, Franz Heinemann, Federica Maschietto, Malay Patra, Olivier Blacque, Ilaria Ciofini, Bernhard Spingler, Gilles Gasser A Ru(II) polypyridyl complex bearing aldehyde functions as a versatile synthetic precursor for long-wavelength absorbing photodynamic therapy photosensitizers published pages: 2666-2675, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2019.05.011	Bioorganic & Medicinal Chemistry 27/12	2019-11-22
2019	Johannes Karges, Marta Jakubaszek, Cristina Mari, Kristof Zarschler, Bruno Goud, Holger Stephan, Gilles Gasser Synthesis and Characterization of an Epidermal Growth Factor Receptorâ€Selective Ru II Polypyridylâ€“Nanobody Conjugate as a Photosensitizer for Photodynamic Therapy published pages: , ISSN: 1439-4227, DOI: 10.1002/cbic.201900419	ChemBioChem	2019-11-22
2019	Johannes Karges, Olivier Blacque, Philippe Goldner, Hui Chao, Gilles Gasser Towards Long Wavelength Absorbing Photodynamic Therapy Photosensitizers via the Extension of a [Ru(bipy) 3 ] 2+ Core published pages: 3704-3712, ISSN: 1434-1948, DOI: 10.1002/ejic.201900569	European Journal of Inorganic Chemistry 2019/32	2019-11-22
2019	Anna K. Renfrew, Johannes Karges, Rosario Scopelliti, Felix D. Bobbink, Patrycja Nowakâ€Sliwinska, Gilles Gasser, Paul J. Dyson Towards Lightâ€Activated Rutheniumâ€“Arene (RAPTAâ€Type) Prodrug Candidates published pages: 2876-2882, ISSN: 1439-4227, DOI: 10.1002/cbic.201900236	ChemBioChem 20/22	2019-11-22
2019	Johannes Karges, Olivier Blacque, Marta Jakubaszek, Bruno Goud, Philippe Goldner, Gilles Gasser Systematic investigation of the antiproliferative activity of a series of ruthenium terpyridine complexes published pages: 110752, ISSN: 0162-0134, DOI: 10.1016/j.jinorgbio.2019.110752	Journal of Inorganic Biochemistry 198	2019-11-22
2018	Marta Jakubaszek, Bruno Goud, Stefano Ferrari, Gilles Gasser Mechanisms of action of Ru( ii ) polypyridyl complexes in living cells upon light irradiation published pages: 13040-13059, ISSN: 1359-7345, DOI: 10.1039/C8CC05928D	Chemical Communications 54/93	2019-06-07
2019	Uttara Basu, Sven Otto, Katja Heinze, Gilles Gasser Biological Evaluation of the NIR-Emissive Ruby Analogue [Cr(ddpd) 2 ][BF 4 ] 3 as a Photodynamic Therapy Photosensitizer published pages: 37-41, ISSN: 1434-1948, DOI: 10.1002/ejic.201801023	European Journal of Inorganic Chemistry 2019/1	2019-06-07
2019	Afonso P. Basto, Nicoleta Anghel, Riccardo Rubbiani, Joachim MÃ¼ller, David Stibal, Federico Giannini, Georg SÃ¼ss-Fink, Vreni Balmer, Gilles Gasser, Julien Furrer, Andrew Hemphill Targeting of the mitochondrion by dinuclear thiolato-bridged arene ruthenium complexes in cancer cells and in the apicomplexan parasite Neospora caninum published pages: 462-474, ISSN: 1756-5901, DOI: 10.1039/c8mt00307f	Metallomics 11/2	2019-06-07
2019	Younes Ellahioui, Malay Patra, Cristina Mari, Rim Kaabi, Johannes Karges, Gilles Gasser, Santiago GÃ³mez-Ruiz Mesoporous silica nanoparticles functionalised with a photoactive ruthenium( ii ) complex: exploring the formulation of a metal-based photodynamic therapy photosensitiser published pages: 5940-5951, ISSN: 1477-9226, DOI: 10.1039/c8dt02392a	Dalton Transactions 48/18	2019-06-07
2018	Sul Hwa Yu, Malay Patra, Stefano Ferrari, Paulina Ramirez Garcia, Nicholas A. Veldhuis, Lisa M. Kaminskas, Bim Graham, John F. Quinn, Michael R. Whittaker, Gilles Gasser, Thomas P. Davis Linker chemistry dictates the delivery of a phototoxic organometallic rhenium( i ) complex to human cervical cancer cells from core crosslinked star polymer nanoparticles published pages: 7805-7810, ISSN: 2050-7518, DOI: 10.1039/C8TB02464B	Journal of Materials Chemistry B 6/47	2019-06-07
2019	Johannes Karges, Philippe Goldner, Gilles Gasser Synthesis, Characterization, and Biological Evaluation of Red-Absorbing Fe(II) Polypyridine Complexes published pages: 4, ISSN: 2304-6740, DOI: 10.3390/inorganics7010004	Inorganics 7/1	2019-06-07
2018	Karun Mutreja, Jana Krietsch, Jeannine Hess, Sebastian Ursich, Matteo Berti, Fabienne K. Roessler, Ralph Zellweger, Malay Patra, Gilles Gasser, Massimo Lopes ATR-Mediated Global Fork Slowing and Reversal Assist Fork Traverse and Prevent Chromosomal Breakage at DNA Interstrand Cross-Links published pages: 2629-2642.e5, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.08.019	Cell Reports 24/10	2019-06-07
2018	Faustine d\'Orchymont, Jeannine Hess, Gordana Panic, Marta Jakubaszek, Lea Gemperle, Jennifer Keiser, Gilles Gasser Synthesis, characterization and biological activity of organometallic derivatives of the antimalarial drug mefloquine as new antischistosomal drug candidates published pages: 1905-1909, ISSN: 2040-2503, DOI: 10.1039/c8md00396c	MedChemComm 9/11	2019-06-07
2018	Marie Flamme, Emma Clarke, Gilles Gasser, Marcel Hollenstein Applications of Ruthenium Complexes Covalently Linked to Nucleic Acid Derivatives published pages: 1515, ISSN: 1420-3049, DOI: 10.3390/molecules23071515	Molecules 23/7	2019-06-07

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