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Opendata, web and dolomites

SMILE

Synchrotron Miniaturization enabling Innovative Laboratory Equipment in soft x-ray tomography.

Total Cost €

EC-Contrib. €

Partnership

Views

Outcomes and
results

SMILE project word cloud

Explore the words cloud of the SMILE project. It provides you a very rough idea of what is the project "SMILE" about.

healthcare optical imaging researcher disease predicted disruptive hours 3m2 resolution image customer fold labs market ease ray annually natural soft reducing restricted miniaturizing exists progression 500 queue million regulatory synchrotron delivered moving 3d approx 200 source commercial therapy gives daily electron addressable microscope prototype relates months cell sxt100 discovery subcellular assembly siriusxt technologies near innovation model suitable serviceability pilots spend images drug six contrast 000m2 structure microscopes generating size world area cells carry 500m internal locations few productivity manufacturing business biological smile 15 global cures

Project "SMILE" data sheet

The following table provides information about the project.

Coordinator	SIRIUSXT LIMITED Organization address address: SUITTE 133, SCIENCE CENTRE NORTH, BELFIELD city: DUBLIN postcode: 4 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Ireland [IE]
Project website	http://www.siriusxt.com
Total cost	3˙000˙935 €
EC max contribution	3˙000˙935 € (100%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-SMEINST-2-2016-2017
Funding Scheme	SME-2
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2019-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	SIRIUSXT LIMITED SIRIUSXT LIMITED Organization address address: SUITTE 133, SCIENCE CENTRE NORTH, BELFIELD city: DUBLIN postcode: 4 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	coordinator	3˙000˙935.00

Map

Project objective

The aim of SMILE is to support SiriusXT in moving a prototype of its soft x-ray microscope (SXT100) from prototype to commercial product through addressing ease-of-assembly, manufacturing scale-up, serviceability, customer pilots, regulatory pathways and business model requirements. The disruptive innovation delivered by SMILE is to open up the market for soft x-ray imaging from approx. 100 users today to an immediate target addressable market of over 3,000 disease research and drug discovery organisations by reducing the cost of the microscope assembly by a factor of over 200 (from over €500 million to €2.5 million) and miniaturizing its size, by a factor of 5,000 (from 15,000m2 area to approx. 3m2). Soft x-ray imaging is the only means available today of generating high resolution, high contrast, 3D images of the internal structure of whole biological cells in their near-natural state. Cell researchers currently spend approx. €500m annually on electron and optical microscopes in order to increase their understanding of subcellular structure and how this relates to disease progression and therapy, however neither of these technologies is capable of imaging the whole internal cell structure. The SXT100 gives disease research and drug discovery organisations daily access to a soft x-ray microscope in their own labs, rather than having to queue for often more than six months to get a few hours of access to one of only four synchrotron locations around the world where a suitable soft x-ray source and microscope exists today. The SXT100 will not only increase a researcher’s productivity 100-fold, in the number of biological cells they can image, but it also allows them to carry out a range of disease progression studies, not possible today because of the restricted access to these synchrotron microscopes. SMILE is predicted to have a significant impact in addressing the EU/global challenge in reducing the cost of healthcare delivery and developing cures for disease.

Deliverables

List of deliverables.
D3.3: Demo Inline Fluorescence Microscope	Demonstrators, pilots, prototypes	2019-09-09 12:57:49
D3.2: Demo Sample Holder	Demonstrators, pilots, prototypes	2019-09-09 12:57:49
D7.5 PR	Websites, patent fillings, videos etc.	2019-09-09 12:57:49
D2.4: Assembly & Test	Demonstrators, pilots, prototypes	2019-09-09 12:57:49
D7.3: Website	Websites, patent fillings, videos etc.	2019-09-09 12:57:49

Take a look to the deliverables list in detail: detailed list of SMILE deliverables.

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The information about "SMILE" are provided by the European Opendata Portal: CORDIS opendata.