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GAIT

From symptom relief to disease modifying allergy treatment with Glycan-Allergen Immunotherapy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 GAIT project word cloud

Explore the words cloud of the GAIT project. It provides you a very rough idea of what is the project "GAIT" about.

initialize    healthy    prevalence    replace    corticosteroids    allergen    company    clinical    market    grass    placebo    attempts    sia    protection    incorporated    plans    global    tolerance    endogenous    worldwide    allergens    refine    substances    safe    glycans    mechanisms    instead    disease    chronic    negotiations    immunotherapy    individuals    medicine    pharmaceutical    patient    decongestants    immune    dc4u    alleviating    risks    pollen    treat    human    diseases    recognition    efficacy    strategy    dose    alarming    investors    curative    self    ipr    doses    underlying    responsible    license    characterised    symptom    medical    course    pace    life    shown    extract    healthcare    therapeutics    business    suited    trials    develops    vivo    followed    plan    treatment    elaborated    relieving    elaborate    dominated    allergy    generation    harm    protein    licensing    cured    sme    ait    therapy    20    severe    annual    gp    profitability    inducing    proprietary    iia    modifying    antihistamines   

Project "GAIT" data sheet

The following table provides information about the project.

Coordinator
DC4U 

Organization address
address: DE CORRIDOR 21E
city: BREUKELEN
postcode: 3621 ZA
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://www.dc4u-technologies.nl
 Total cost 71˙429 €
 EC max contribution 50˙000 € (70%)
 Programme 1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology)
2. H2020-EU.2.3.1. (Mainstreaming SME support, especially through a dedicated instrument)
 Code Call H2020-SMEINST-1-2016-2017
 Funding Scheme SME-1
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2017-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DC4U NL (BREUKELEN) coordinator 50˙000.00

Map

 Project objective

The annual increase in prevalence of allergy related diseases develops at an alarming pace worldwide. Responsible disease mechanisms are characterised by unwanted immune responses to substances which do not harm healthy individuals. The allergy therapeutics market is now dominated by symptom alleviating antihistamines, decongestants and corticosteroids. The main patient need is to get cured with a disease modifying medicine instead of the chronic use of symptom relieving products. Allergen-specific Immunotherapy (AIT) attempts to treat the underlying cause by inducing allergen-specific immune tolerance. However, currently used AIT with high doses of extract is not effective enough (only 20% better than placebo), risks severe side effects and requires 5 years of treatment.

DC4U is developing a new generation of disease modifying allergy treatment with the potential to replace symptom relieving products and current AIT. We apply a new and unique technology to present allergens to the immune system as being SELF and SAFE, using glycans as endogenous human protein recognition elements. Our lead product, “sia-GP”, is a grass pollen allergy treatment for life long protection, achieved in a short treatment course. DC4U has shown highly promising in-vivo dose-response efficacy results and will further develop this proprietary product up to and including Phase IIa clinical trials. This will be followed by out-licensing to a pharmaceutical company. Effective curative tolerance inducing therapy will contribute to global medical needs and reduction of healthcare costs.

In this SME-1 we will elaborate and refine our clinical plans, IPR strategy, market analysis and profitability analysis. Furthermore, we will initialize discussions and negotiations with several possible investors and licensing partners. All will be incorporated in an elaborated European business plan with best suited to out-license sia-GP after Phase IIa clinical trials.

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The information about "GAIT" are provided by the European Opendata Portal: CORDIS opendata.

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