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GAIT

From symptom relief to disease modifying allergy treatment with Glycan-Allergen Immunotherapy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 GAIT project word cloud

Explore the words cloud of the GAIT project. It provides you a very rough idea of what is the project "GAIT" about.

plans    medical    replace    dc4u    protection    followed    tolerance    modifying    immune    iia    worldwide    allergens    immunotherapy    dominated    protein    generation    initialize    pollen    mechanisms    allergen    diseases    pharmaceutical    attempts    elaborate    ipr    placebo    endogenous    plan    patient    therapy    pace    shown    recognition    strategy    healthcare    refine    investors    ait    efficacy    chronic    disease    allergy    sia    responsible    clinical    suited    curative    negotiations    prevalence    medicine    incorporated    risks    sme    treat    profitability    proprietary    cured    license    instead    relieving    inducing    decongestants    individuals    safe    doses    alleviating    vivo    20    licensing    human    substances    alarming    dose    severe    extract    trials    therapeutics    company    underlying    treatment    grass    business    course    healthy    harm    antihistamines    self    develops    corticosteroids    characterised    market    glycans    annual    global    life    elaborated    gp    symptom   

Project "GAIT" data sheet

The following table provides information about the project.

Coordinator
DC4U 

Organization address
address: DE CORRIDOR 21E
city: BREUKELEN
postcode: 3621 ZA
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://www.dc4u-technologies.nl
 Total cost 71˙429 €
 EC max contribution 50˙000 € (70%)
 Programme 1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology)
2. H2020-EU.2.3.1. (Mainstreaming SME support, especially through a dedicated instrument)
 Code Call H2020-SMEINST-1-2016-2017
 Funding Scheme SME-1
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2017-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DC4U NL (BREUKELEN) coordinator 50˙000.00

Map

 Project objective

The annual increase in prevalence of allergy related diseases develops at an alarming pace worldwide. Responsible disease mechanisms are characterised by unwanted immune responses to substances which do not harm healthy individuals. The allergy therapeutics market is now dominated by symptom alleviating antihistamines, decongestants and corticosteroids. The main patient need is to get cured with a disease modifying medicine instead of the chronic use of symptom relieving products. Allergen-specific Immunotherapy (AIT) attempts to treat the underlying cause by inducing allergen-specific immune tolerance. However, currently used AIT with high doses of extract is not effective enough (only 20% better than placebo), risks severe side effects and requires 5 years of treatment.

DC4U is developing a new generation of disease modifying allergy treatment with the potential to replace symptom relieving products and current AIT. We apply a new and unique technology to present allergens to the immune system as being SELF and SAFE, using glycans as endogenous human protein recognition elements. Our lead product, “sia-GP”, is a grass pollen allergy treatment for life long protection, achieved in a short treatment course. DC4U has shown highly promising in-vivo dose-response efficacy results and will further develop this proprietary product up to and including Phase IIa clinical trials. This will be followed by out-licensing to a pharmaceutical company. Effective curative tolerance inducing therapy will contribute to global medical needs and reduction of healthcare costs.

In this SME-1 we will elaborate and refine our clinical plans, IPR strategy, market analysis and profitability analysis. Furthermore, we will initialize discussions and negotiations with several possible investors and licensing partners. All will be incorporated in an elaborated European business plan with best suited to out-license sia-GP after Phase IIa clinical trials.

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The information about "GAIT" are provided by the European Opendata Portal: CORDIS opendata.

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