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Anticancer-PAM

Anticancer activity of plasma activated medium and its underlying mechanisms: Combined experimental and computational study

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

Anticancer-PAM project word cloud

Explore the words cloud of the Anticancer-PAM project. It provides you a very rough idea of what is the project "Anticancer-PAM" about.

overcoming gaining experiments created cold catalase seems generally treatment calculate reactive anti anticancer direct simulations oxygen itself cancer activated atomic aids medium perform rons patients stress stages exactly nitrogen activate oxidative cap atmospheric concentrations model injected effect pam species protein understand besides cells interaction liquid tissue plasma

Project "Anticancer-PAM" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITEIT ANTWERPEN Organization address address: PRINSSTRAAT 13 city: ANTWERPEN postcode: 2000 website: www.ua.ac.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Belgium [BE]
Project website	http://nano.uantwerpen.be/nanorefs/search.php
Total cost	160˙800 €
EC max contribution	160˙800 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-09-01 to 2019-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITEIT ANTWERPEN UNIVERSITEIT ANTWERPEN Organization address address: PRINSSTRAAT 13 city: ANTWERPEN postcode: 2000 website: www.ua.ac.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (ANTWERPEN)	coordinator	160˙800.00

Map

Project objective

Cold atmospheric plasma (CAP) is gaining increasing interest for cancer treatment, although the application is still in its early stages. Besides direct CAP treatment of cancer cells, plasma can also be used to activate a liquid medium, which seems to have similar anti-cancer effects as the plasma itself. This so-called plasma activated medium (PAM) is very promising for cancer treatment, as it can be more generally used, e.g., it might be directly injected into tissue of patients. However, the anticancer potential of PAM is not yet fully understood. This is exactly the focus of this project. We will measure the reactive oxygen and nitrogen species (RONS) concentrations in PAM, and also calculate them with a model for plasma-liquid interaction. In addition, we will study the effect of PAM on a catalase model protein by experiments, and perform atomic scale simulations for the interaction of RONS with this protein, to better understand the effect of PAM on cancer cells, because catalase aids cancer cells in overcoming oxidative stress created by PAM.

Publications

List of publications.
year	authors and title	journal	last update
2018	Naresh Kumar, Pankaj Attri, Sylvia Dewilde, Annemie Bogaerts Inactivation of human pancreatic ductal adenocarcinoma with atmospheric plasma treated media and water: a comparative study published pages: 255401, ISSN: 0022-3727, DOI: 10.1088/1361-6463/aac571	Journal of Physics D: Applied Physics 51/25	2020-03-11
2018	Naresh Kumar, Priyanka Shaw, Jamoliddin Razzokov, Maksudbek Yusupov, Pankaj Attri, Han Sup Uhm, Eun Ha Choi, Annemie Bogaerts Enhancement of cellular glucose uptake by reactive species: a promising approach for diabetes therapy published pages: 9887-9894, ISSN: 2046-2069, DOI: 10.1039/c7ra13389h	RSC Advances 8/18	2020-03-11
2019	Bhagirath Ghimire, Endre J. Szili, Pradeep Lamichhane, Robert D. Short, Jun Sup Lim, Pankaj Attri, Kai Masur, Klaus-Dieter Weltmann, Sung-Ha Hong, Eun Ha Choi The role of UV photolysis and molecular transport in the generation of reactive species in a tissue model with a cold atmospheric pressure plasma jet published pages: 93701, ISSN: 0003-6951, DOI: 10.1063/1.5086522	Applied Physics Letters 114/9	2020-03-11
2019	Pankaj Attri, Annemie Bogaerts Perspectives of Plasma-treated Solutions as Anticancer Drugs published pages: 436-438, ISSN: 1871-5206, DOI: 10.2174/187152061904190521102345	Anti-Cancer Agents in Medicinal Chemistry 19/4	2020-03-11

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