ChirPyr SIGNED
Access to chiral pyridine derivatives via catalytic asymmetric synthesis
Total Cost €
0EC-Contrib. €
0Partnership
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0ChirPyr project word cloud
Explore the words cloud of the ChirPyr project. It provides you a very rough idea of what is the project "ChirPyr" about.
Project "ChirPyr" data sheet
The following table provides information about the project.
| Coordinator |
RIJKSUNIVERSITEIT GRONINGEN
Organization address contact info |
| Coordinator Country | Netherlands [NL] |
| Project website | http://www.sr-harutyunyan.com |
| Total cost | 177˙598 € |
| EC max contribution | 177˙598 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2016 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-10-01 to 2019-09-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | RIJKSUNIVERSITEIT GRONINGEN | NL (GRONINGEN) | coordinator | 177˙598.00 |
Map
Project objective
Pyridine and its derivatives are abundant structural motives in nature and widely used in medicinal chemistry. In this research program we propose to develop catalytic enantioselective methods for the synthesis of chiral pyridines with tertiary and quaternary stereocenters through the catalytic addition of readily available and highly reactive organometallics to conjugated alkenyl pyridines. Furthermore, the proposed methodology will be used for the generation of contiguous stereocenters via sequential conjugate addition/Mg-aza-enolate trapping strategies. The synthesis of this kind of chiral compounds will permit further functionalization of pyridine products through the partial or total hydrogenation reactions of aromatic pyridine rings, or the introduction of different electrophiles in various positions of the aromatic ring.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Denisa Vargová, Juana M. Pérez, Syuzanna R. Harutyunyan, Radovan Šebesta Trapping of chiral enolates generated by Lewis acid promoted conjugate addition of Grignard reagents to unreactive Michael acceptors by various electrophiles published pages: 11766-11769, ISSN: 1359-7345, DOI: 10.1039/c9cc05041h |
Chemical Communications 55/78 | 2020-04-08 |
| 2019 |
Francesco Lanza, Juana Pérez, Ravindra Jumde, Syuzanna Harutyunyan Lewis Acid Promoted Trapping of Chiral Aza-enolates published pages: 1253-1262, ISSN: 0039-7881, DOI: 10.1055/s-0037-1611657 |
Synthesis 51/05 | 2020-04-08 |
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