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IndiVISUAL

Role of individual retinal ganglion cell types in visual computation and behaviors

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 IndiVISUAL project word cloud

Explore the words cloud of the IndiVISUAL project. It provides you a very rough idea of what is the project "IndiVISUAL" about.

movements    processed    photon    inputs    vivo    brain    evoked    pharmacogenetic    bodies    innate    retino    pattern    visual    streamed    understand    discrimination    cells    accessory    function    link    ganglion    contains    cre    nucleus    time    insights    first    individual    activate    originating    imaging    behaviors    morphologically    cell    release    thousands    expressing    behavior    restricted    physiologically    superior    retinal    geniculate    silence    functionally    head    circuits    gain    escape    eye    recipient    morphological    region    compensatory    labeled    mechanistic    retina    approximately    visually    activation    colliculus    projections    optogenetic    nervous    mouse    neuronal    channels    relevance    selective    regions    convergence    cortex    mediated    layers    axonal    utilizing    terminals    lines    transgenic    divergence    mosaic    physiological    terminal    computation    lateral    tools    synaptic    optic    silencing    light    types   

Project "IndiVISUAL" data sheet

The following table provides information about the project.

Coordinator
AARHUS UNIVERSITET 

Organization address
address: NORDRE RINGGADE 1
city: AARHUS C
postcode: 8000
website: www.au.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website http://www.yoneharalab.com/
 Total cost 212˙194 €
 EC max contribution 212˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AARHUS UNIVERSITET DK (AARHUS C) coordinator 212˙194.00

Map

 Project objective

The nervous system contains thousands of morphologically and physiologically different neuronal cell types, organized in distinct circuits. Information processed by the retina is streamed into more than 10 retino-recipient brain regions through approximately 20 distinct visual channels, originating in retinal ganglion cell types. One key feature of visual processing is significant convergence and divergence of retinal ganglion cell type inputs to different brain regions. The objective of this proposal is to understand the relevance of this convergence and divergence of visual pathways. Recently, we have identified several Cre transgenic mouse lines in which labeled ganglion cells show a mosaic-like distribution pattern of ganglion cell bodies in the retina and restricted axonal projections in the retino-recipient layers of the lateral geniculate nucleus, superior colliculus, and accessory optic system. Utilizing these new cell-type-labeled mouse lines, we will first characterize the morphological and physiological properties of Cre-expressing cell types. Next, we will silence or activate the synaptic release of individual cell types at a selective terminal region, such as the visual cortex and superior colliculus, using pharmacogenetic and optogenetic tools, and test their effects on light responses by in-vivo two-photon imaging. Finally, we will investigate the effects of silencing and activation of individual synaptic terminals on behaviors that it has been proposed are mediated by specific visual pathways: visual discrimination mediated by the retino-geniculate pathway; innate escape and approach behavior by the superior colliculus; and visually evoked compensatory head and eye movements by the accessory optic pathway. We aim to link, for the first time, individual pathways of ganglion cell type function with visual computation and behavior in order to gain mechanistic insights into how neuronal circuits are functionally organized in our brain.

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The information about "INDIVISUAL" are provided by the European Opendata Portal: CORDIS opendata.

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