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ARC-NeuroHet SIGNED

Unravelling neuronal heterogeneity in energy homeostasis regulation

Total Cost €

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EC-Contrib. €

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Partnership

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 ARC-NeuroHet project word cloud

Explore the words cloud of the ARC-NeuroHet project. It provides you a very rough idea of what is the project "ARC-NeuroHet" about.

brain    exceptional    deregulation    expression    msca    subpopulation    population    circuits    hormonal    regulate    p2y6    projections    sub    nucleus    unknown    food    total    neuron    expenditure    neuronal    integrate    balance    axonal    genetically    unravel    glucose    opportunity    map    reinforce    obesity    homeostasis    prominent    adapt    recombinase    systemic    insulin    receptor    molecular    blood    physiological    function    sensitivity    vivo    signals    strategies    regulation    technologies    diabetes    participate    drugable    nutrient    neurons    unveil    dissect    first    plan    combine    arc    populations    maintenance    curb    line    actual    facet    udp    professional    innovative    circuit    chronic    location    arcuate    completion    agrp    diseases    activation    energy    implicated    fellowship    techniques    downstream    heterogeneity    hypothalamus    markers    independent    maturity    intake    evidences    activators    reintegration    dynamic    experimental   

Project "ARC-NeuroHet" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: Munich
postcode: 80539
website: www.mpg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2019-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (Munich) coordinator 171˙460.00

Map

 Project objective

This MSCA Reintegration proposal is aimed to study the heterogeneity of neuronal populations implicated in the maintenance of energy balance. Because of their location, neurons in the arcuate nucleus of the hypothalamus (ARC) integrate nutrient and hormonal signals carried in the blood. Then, they regulate downstream neuron’s activity in order to adapt food intake and energy expenditure. Deregulation of energy homeostasis can lead to obesity and diabetes, two of the major chronic diseases in the EU. AgRP neurons, an ARC population, have a prominent role in the regulation of food intake and systemic insulin sensitivity. They establish axonal projections with several brain areas and recent evidences show that each sub-circuit can have a specific function in the regulation of food intake and/or glucose homeostasis. For this fellowship I propose to use an innovative experimental approach to investigate a specific novel AgRP neuronal subpopulation, characterized by the expression of the UDP-receptor, P2Y6, as a first step to unravel the heterogeneity of the total population. Although P2Y6 activation increases short-term food intake, its effects on glucose homeostasis are still unknown. I plan to combine new recombinase technologies with state of the art techniques to genetically identify the AgRP, P2Y6 subpopulation and then: 1) characterize their in vivo dynamic response to physiological activators; 2) map specific AgRP, P2Y6 sub-circuits and dissect their role in each facet of energy homeostasis; and 3) investigate new molecular markers, as possible drugable targets. Results from this project will unveil new aspects of neuronal heterogeneity that participate in the regulation of energy homeostasis and will contribute to design new strategies to curb the actual obesity trends. The completion of this MSCA fellowship represents an exceptional opportunity to reinforce my professional maturity and to develop my independent research line.

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The information about "ARC-NEUROHET" are provided by the European Opendata Portal: CORDIS opendata.

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