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ARC-NeuroHet SIGNED

Unravelling neuronal heterogeneity in energy homeostasis regulation

Total Cost €

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EC-Contrib. €

0

Partnership

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 ARC-NeuroHet project word cloud

Explore the words cloud of the ARC-NeuroHet project. It provides you a very rough idea of what is the project "ARC-NeuroHet" about.

genetically    integrate    systemic    technologies    insulin    first    brain    physiological    facet    location    total    completion    techniques    intake    glucose    independent    experimental    innovative    fellowship    circuit    signals    arcuate    sub    populations    opportunity    markers    chronic    food    balance    blood    reinforce    evidences    activators    plan    expenditure    molecular    heterogeneity    deregulation    dynamic    msca    actual    diabetes    arc    drugable    neuronal    homeostasis    maturity    implicated    circuits    activation    p2y6    line    reintegration    strategies    hormonal    professional    sensitivity    adapt    prominent    downstream    agrp    nucleus    recombinase    unveil    dissect    function    expression    population    energy    unravel    maintenance    curb    udp    participate    vivo    exceptional    neurons    nutrient    map    hypothalamus    regulate    subpopulation    obesity    receptor    combine    unknown    diseases    neuron    regulation    axonal    projections   

Project "ARC-NeuroHet" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: Munich
postcode: 80539
website: www.mpg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2019-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (Munich) coordinator 171˙460.00

Map

 Project objective

This MSCA Reintegration proposal is aimed to study the heterogeneity of neuronal populations implicated in the maintenance of energy balance. Because of their location, neurons in the arcuate nucleus of the hypothalamus (ARC) integrate nutrient and hormonal signals carried in the blood. Then, they regulate downstream neuron’s activity in order to adapt food intake and energy expenditure. Deregulation of energy homeostasis can lead to obesity and diabetes, two of the major chronic diseases in the EU. AgRP neurons, an ARC population, have a prominent role in the regulation of food intake and systemic insulin sensitivity. They establish axonal projections with several brain areas and recent evidences show that each sub-circuit can have a specific function in the regulation of food intake and/or glucose homeostasis. For this fellowship I propose to use an innovative experimental approach to investigate a specific novel AgRP neuronal subpopulation, characterized by the expression of the UDP-receptor, P2Y6, as a first step to unravel the heterogeneity of the total population. Although P2Y6 activation increases short-term food intake, its effects on glucose homeostasis are still unknown. I plan to combine new recombinase technologies with state of the art techniques to genetically identify the AgRP, P2Y6 subpopulation and then: 1) characterize their in vivo dynamic response to physiological activators; 2) map specific AgRP, P2Y6 sub-circuits and dissect their role in each facet of energy homeostasis; and 3) investigate new molecular markers, as possible drugable targets. Results from this project will unveil new aspects of neuronal heterogeneity that participate in the regulation of energy homeostasis and will contribute to design new strategies to curb the actual obesity trends. The completion of this MSCA fellowship represents an exceptional opportunity to reinforce my professional maturity and to develop my independent research line.

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The information about "ARC-NEUROHET" are provided by the European Opendata Portal: CORDIS opendata.

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