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PHYSBIOHSC SIGNED

Understanding the physical biology of adult blood stem cells

Total Cost €

EC-Contrib. €

Partnership

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PHYSBIOHSC project word cloud

Explore the words cloud of the PHYSBIOHSC project. It provides you a very rough idea of what is the project "PHYSBIOHSC" about.

cells iterative clonal microfluidic diseases heterogeneity individual stem cancer blood biology cell biomechanics combine physical leveraging shifted inter discovery single populations functional evolution mutations human subverted manner quantitative assays clinical diversity therapies biological mathematical vivo understand critical drive vitro disciplinary mouse origin technologies normal functionally malignant

Project "PHYSBIOHSC" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY OF YORK Organization address address: HESLINGTON city: YORK NORTH YORKSHIRE postcode: YO10 5DD website: http://www.york.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	1˙500˙000 €
EC max contribution	1˙500˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2016-STG
Funding Scheme	ERC-STG
Starting year	2017
Duration (year-month-day)	from 2017-05-01 to 2022-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY OF YORK UNIVERSITY OF YORK Organization address address: HESLINGTON city: YORK NORTH YORKSHIRE postcode: YO10 5DD website: http://www.york.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (YORK NORTH YORKSHIRE)	coordinator	1˙046˙670.00
2	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	453˙330.00

Map

Project objective

The discovery of functional heterogeneity in normal and malignant stem cells has shifted our understanding of how single cells are subverted to drive cancer. To design therapies for diseases of stem cell origin and to better provide cell populations for clinical applications, it is critical to understand this diversity at the single cell level. This proposal focuses on understanding the complex biology of normal and malignant stem cells and the impact of individual mutations on clonal evolution by studying the physical and quantitative aspects of single blood stem cells.

This proposal aims to study single blood stem cell biomechanics and clonal evolution by leveraging new inter-disciplinary technologies and approaches and applying them to functionally defined mouse and human blood stem cell populations. It will combine in vitro and in vivo biological assays with mathematical modelling and microfluidic technology in an iterative manner across both human and mouse stem cell populations.

Deliverables

List of deliverables.
Data Management Plan	Open Research Data Pilot	2019-11-11 10:00:11

Take a look to the deliverables list in detail: detailed list of PHYSBIOHSC deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Anne-Marie Lyne, David G. Kent, Elisa Laurenti, Kerstin Cornils, Ingmar Glauche, LeÃ¯la PeriÃ© A track of the clones: new developments in cellular barcoding published pages: 15-20, ISSN: 0301-472X, DOI: 10.1016/j.exphem.2018.11.005	Experimental Hematology 68	2020-01-28
2018	Henry Lee-Six, Nina Friesgaard Ã˜bro, Mairi S. Shepherd, Sebastian Grossmann, Kevin Dawson, Miriam Belmonte, Robert J. Osborne, Brian J. P. Huntly, Inigo Martincorena, Elizabeth Anderson, Laura Oâ€™Neill, Michael R. Stratton, Elisa Laurenti, Anthony R. Green, David G. Kent, Peter J. Campbell Population dynamics of normal human blood inferred from somatic mutations published pages: 473-478, ISSN: 0028-0836, DOI: 10.1038/s41586-018-0497-0	Nature 561/7724	2019-11-11

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The information about "PHYSBIOHSC" are provided by the European Opendata Portal: CORDIS opendata.