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PHYSBIOHSC SIGNED

Understanding the physical biology of adult blood stem cells

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "PHYSBIOHSC" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF YORK 

Organization address
address: HESLINGTON
city: YORK NORTH YORKSHIRE
postcode: YO10 5DD
website: http://www.york.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2022-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF YORK UK (YORK NORTH YORKSHIRE) coordinator 1˙046˙670.00
2    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 453˙330.00

Map

 Project objective

The discovery of functional heterogeneity in normal and malignant stem cells has shifted our understanding of how single cells are subverted to drive cancer. To design therapies for diseases of stem cell origin and to better provide cell populations for clinical applications, it is critical to understand this diversity at the single cell level. This proposal focuses on understanding the complex biology of normal and malignant stem cells and the impact of individual mutations on clonal evolution by studying the physical and quantitative aspects of single blood stem cells.

This proposal aims to study single blood stem cell biomechanics and clonal evolution by leveraging new inter-disciplinary technologies and approaches and applying them to functionally defined mouse and human blood stem cell populations. It will combine in vitro and in vivo biological assays with mathematical modelling and microfluidic technology in an iterative manner across both human and mouse stem cell populations.

 Deliverables

List of deliverables.
Data Management Plan Open Research Data Pilot 2019-11-11 10:00:11

Take a look to the deliverables list in detail:  detailed list of PHYSBIOHSC deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Anne-Marie Lyne, David G. Kent, Elisa Laurenti, Kerstin Cornils, Ingmar Glauche, Leïla Perié
A track of the clones: new developments in cellular barcoding
published pages: 15-20, ISSN: 0301-472X, DOI: 10.1016/j.exphem.2018.11.005
Experimental Hematology 68 2020-01-28
2018 Henry Lee-Six, Nina Friesgaard Øbro, Mairi S. Shepherd, Sebastian Grossmann, Kevin Dawson, Miriam Belmonte, Robert J. Osborne, Brian J. P. Huntly, Inigo Martincorena, Elizabeth Anderson, Laura O’Neill, Michael R. Stratton, Elisa Laurenti, Anthony R. Green, David G. Kent, Peter J. Campbell
Population dynamics of normal human blood inferred from somatic mutations
published pages: 473-478, ISSN: 0028-0836, DOI: 10.1038/s41586-018-0497-0
Nature 561/7724 2019-11-11

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The information about "PHYSBIOHSC" are provided by the European Opendata Portal: CORDIS opendata.

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