PHYSBIOHSC SIGNED
Understanding the physical biology of adult blood stem cells
Total Cost €
0EC-Contrib. €
0Partnership
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Explore the words cloud of the PHYSBIOHSC project. It provides you a very rough idea of what is the project "PHYSBIOHSC" about.
Project "PHYSBIOHSC" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITY OF YORK
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Total cost | 1˙500˙000 € |
| EC max contribution | 1˙500˙000 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2016-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-05-01 to 2022-04-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITY OF YORK | UK (YORK NORTH YORKSHIRE) | coordinator | 1˙046˙670.00 |
| 2 | THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE | UK (CAMBRIDGE) | participant | 453˙330.00 |
Map
Project objective
The discovery of functional heterogeneity in normal and malignant stem cells has shifted our understanding of how single cells are subverted to drive cancer. To design therapies for diseases of stem cell origin and to better provide cell populations for clinical applications, it is critical to understand this diversity at the single cell level. This proposal focuses on understanding the complex biology of normal and malignant stem cells and the impact of individual mutations on clonal evolution by studying the physical and quantitative aspects of single blood stem cells.
This proposal aims to study single blood stem cell biomechanics and clonal evolution by leveraging new inter-disciplinary technologies and approaches and applying them to functionally defined mouse and human blood stem cell populations. It will combine in vitro and in vivo biological assays with mathematical modelling and microfluidic technology in an iterative manner across both human and mouse stem cell populations.
Deliverables
| Data Management Plan | Open Research Data Pilot | 2019-11-11 10:00:11 |
Take a look to the deliverables list in detail: detailed list of PHYSBIOHSC deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
Anne-Marie Lyne, David G. Kent, Elisa Laurenti, Kerstin Cornils, Ingmar Glauche, Leïla Perié A track of the clones: new developments in cellular barcoding published pages: 15-20, ISSN: 0301-472X, DOI: 10.1016/j.exphem.2018.11.005 |
Experimental Hematology 68 | 2020-01-28 |
| 2018 |
Henry Lee-Six, Nina Friesgaard Øbro, Mairi S. Shepherd, Sebastian Grossmann, Kevin Dawson, Miriam Belmonte, Robert J. Osborne, Brian J. P. Huntly, Inigo Martincorena, Elizabeth Anderson, Laura O’Neill, Michael R. Stratton, Elisa Laurenti, Anthony R. Green, David G. Kent, Peter J. Campbell Population dynamics of normal human blood inferred from somatic mutations published pages: 473-478, ISSN: 0028-0836, DOI: 10.1038/s41586-018-0497-0 |
Nature 561/7724 | 2019-11-11 |
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