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ROADMAP

Real world Outcomes across the AD spectrum for better care: Multimodal data Access Platform - Sofia ref.: 116020

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

ROADMAP project word cloud

Explore the words cloud of the ROADMAP project. It provides you a very rough idea of what is the project "ROADMAP" about.

disease integration framework datasets regulators patient providers synergies progression validate handling ad direct traction epidemiologic leverage companies standards focussing epad solutions engaging piloting pool markers economics modal models industry expertise dpuk ethical routinely actionable he interpretation pursue biomedical consist outcome hta elsi connections guidelines outcomes consensual rwe implications diverse outstanding national combining stakeholder collected deepen experts definition sourcing data service emif strategies packages parallel levels informatics communication contribution carers patients scalable foundation health sources tools transferable risk costing platform dataset classification world roadmap social professionals big strategy imi2 brings software characterisation groups

Project "ROADMAP" data sheet

The following table provides information about the project.

Coordinator	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Organization address address: WELLINGTON SQUARE UNIVERSITY OFFICES city: OXFORD postcode: OX1 2JD website: www.ox.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	https://roadmap-alzheimer.org/
Total cost	8˙210˙381 €
EC max contribution	3˙998˙250 € (49%)
Programme	1. H2020-EU.3.1.7. (Innovative Medicines Initiative 2 (IMI2))
Code Call	H2020-JTI-IMI2-2015-06-two-stage
Funding Scheme	IMI2-RIA
Starting year	2016
Duration (year-month-day)	from 2016-11-01 to 2018-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Organization address address: WELLINGTON SQUARE UNIVERSITY OFFICES city: OXFORD postcode: OX1 2JD website: www.ox.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (OXFORD)	coordinator	1˙073˙500.00
2	NATIONAL INSTITUTE FOR HEALTH AND CARE EXCELLENCE NATIONAL INSTITUTE FOR HEALTH AND CARE EXCELLENCE Organization address address: LEVEL 1A CITY TOWER PICCADILLY PLAZA city: MANCHESTER postcode: M1 4BT website: www.nice.org.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (MANCHESTER)	participant	292˙500.00
3	THE UNIVERSITY OF EDINBURGH THE UNIVERSITY OF EDINBURGH Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL website: www.ed.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EDINBURGH)	participant	291˙000.00
4	UNIVERSITEIT MAASTRICHT UNIVERSITEIT MAASTRICHT Organization address address: Minderbroedersberg 4-6 city: MAASTRICHT postcode: 6200 MD website: http://www.maastrichtuniversity.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (MAASTRICHT)	participant	291˙000.00
5	KOBENHAVNS UNIVERSITET KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	participant	252˙000.00
6	GOETEBORGS UNIVERSITET GOETEBORGS UNIVERSITET Organization address address: VASAPARKEN city: GOETEBORG postcode: 405 30 website: www.gu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (GOETEBORG)	participant	250˙500.00
7	AARHUS UNIVERSITET AARHUS UNIVERSITET Organization address address: NORDRE RINGGADE 1 city: AARHUS C postcode: 8000 website: www.au.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (AARHUS C)	participant	212˙250.00
8	FUNDACIO INSTITUT UNIVERSITARI PERA LA RECERCA A L'ATENCIO PRIMARIA DE SALUT JORDI GOL I GURINA FUNDACIO INSTITUT UNIVERSITARI PERA LA RECERCA A L'ATENCIO PRIMARIA DE SALUT JORDI GOL I GURINA Organization address address: GRAN VIA DE LES CORTS CATALANES 587 city: BARCELONA postcode: 8007 website: http://www.idiapjordigol.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	212˙250.00
9	SYNAPSE RESEARCH MANAGEMENT PARTNERS SL SYNAPSE RESEARCH MANAGEMENT PARTNERS SL Organization address address: CALLE VELAZQUEZ 94 PLANTA 1 city: MADRID postcode: 28006 website: www.synapse-managers.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	188˙750.00
10	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Organization address address: DR MOLEWATERPLEIN 40 city: ROTTERDAM postcode: 3015 GD website: www.erasmusmc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ROTTERDAM)	participant	181˙000.00
11	LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE Organization address address: Houghton Street 1 city: LONDON postcode: WC2A 2AE website: www.lse.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	178˙500.00
12	ALZHEIMER EUROPE ALZHEIMER EUROPE Organization address address: RUE DICKS 14 city: LUXEMBOURG postcode: 1417 website: www.alzheimer-europe.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	LU (LUXEMBOURG)	participant	176˙000.00
13	AGENTSCHAP COLLEGE TER BEOORDELING VAN GENEESMIDDELEN AGENTSCHAP COLLEGE TER BEOORDELING VAN GENEESMIDDELEN Organization address address: GRAADT VAN ROGGENWEG 500 city: UTRECHT postcode: 3531AH website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	participant	122˙000.00
14	IXICO TECHNOLOGIES LIMITED IXICO TECHNOLOGIES LIMITED Organization address address: 4TH FLOOR GRIFFIN COURT 15 LONG LANE city: LONDON postcode: EC1A 9PN website: www.ixico.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	117˙000.00
15	ACADEMISCH ZIEKENHUIS LEIDEN ACADEMISCH ZIEKENHUIS LEIDEN Organization address address: ALBINUSDREEF 2 city: LEIDEN postcode: 2333 ZA website: www.lumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	110˙000.00
16	RIJKSUNIVERSITEIT GRONINGEN RIJKSUNIVERSITEIT GRONINGEN Organization address address: Broerstraat 5 city: GRONINGEN postcode: 9712CP website: www.rug.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (GRONINGEN)	participant	50˙000.00
17	AC IMMUNE SA AC IMMUNE SA Organization address address: Parc Scientifique EPFL, PSE B city: Lausanne postcode: 1015 website: www.acimmune.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (Lausanne)	participant	0.00
18	BIOGEN IDEC LIMITED BIOGEN IDEC LIMITED Organization address address: INNOVATION HOUSE 70 NORDEN ROAD city: MAIDENHEAD postcode: SL6 3AY website: http://www.biogen.com/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (MAIDENHEAD)	participant	0.00
19	CHU HOPITAUX DE BORDEAUX CHU HOPITAUX DE BORDEAUX Organization address address: RUE DUBERNAT 12 city: TALENCE postcode: 33404 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (TALENCE)	participant	0.00
20	Eli Lilly and Company Limited Eli Lilly and Company Limited Organization address address: Lilly House, Priestley Road city: Basingstoke postcode: RG24 9NL website: www.lilly.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (Basingstoke)	participant	0.00
21	F. HOFFMANN-LA ROCHE AG F. HOFFMANN-LA ROCHE AG Organization address address: GRENZACHERSTRASSE 124 city: BASEL postcode: 4070 website: www.roche.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BASEL)	participant	0.00
22	GE HEALTHCARE LIMITED GE HEALTHCARE LIMITED Organization address address: AMERSHAM PLACE city: LITTLE CHALFONT postcode: HP7 9NA website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LITTLE CHALFONT)	participant	0.00
23	H. LUNDBECK AS H. LUNDBECK AS Organization address address: OTTILIAVEJ 7-9 city: VALBY postcode: 2500 website: www.lundbeck.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (VALBY)	participant	0.00
24	JANSSEN PHARMACEUTICA NV JANSSEN PHARMACEUTICA NV Organization address address: TURNHOUTSEWEG 30 city: BEERSE postcode: 2340 website: www.janssenpharmaceutica.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BEERSE)	participant	0.00
25	NOVARTIS PHARMA AG NOVARTIS PHARMA AG Organization address address: LICHTSTRASSE 35 city: BASEL postcode: 4056 website: www.novartis.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BASEL)	participant	0.00
26	TAKEDA DEVELOPMENT CENTRE EUROPE LTD TAKEDA DEVELOPMENT CENTRE EUROPE LTD Organization address address: ALDWYCH 61 city: LONDON postcode: WC2B 4AE website: www.takeda.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	0.00

Map

Project objective

The aim of ROADMAP is to provide the foundation for a Europe-wide real world evidence (RWE) platform in AD by piloting multi-modal data integration tools and engaging with all key stakeholder groups for consensual definition of patient outcomes, tools and methods that are actionable and relevant. ROADMAP will leverage best practice and exploit synergies with other projects and initiatives at the national and European levels in pursue of scalable and transferable solutions for dataset characterisation, outcome classification, data standards, data sourcing, software application and guidelines on the handling and interpretation of RWE data. In parallel, the project will deepen understanding of the ethical, legal and social implications (ELSI) and health economics (HE) impact of a RWE approach for a meaningful contribution to the Big Data for Better Outcomes programme in IMI2.

The ROADMAP programme will consist of 8 integrated work packages by which the Consortium will work to (1) identify relevant AD outcomes and progression markersÍ¾ (2) identify and pool AD-related RWE across data sourcesÍ¾ (3) develop and validate disease progression models combining diverse datasets and strategiesÍ¾ (4) develop risk/value-based costing and health economics models for HTA/regulators, service providers, industry and carersÍ¾ (5) establish stakeholder-based guidelines for RWEÍ¾ (6) develop a communication strategy focussing on the needs of patients and professionalsÍ¾ (7) develop an ELSI framework for the development and application of RWE in AD.

The ROADMAP consortium brings together outstanding expertise, experience and traction in the field, including many of Europe’s top institutions, authorities, companies, experts in AD, biomedical informatics and analysis of epidemiologic and routinely collected health data sources, providing direct connections to key initiatives such as DPUK, EMIF, EPAD and others.

Deliverables

List of deliverables.
Final report on dissemination activities (including impact measures) and project tools developed	Documents, reports	2019-10-08 14:19:00
Interim Report on dissemination activities and communication strategy update	Documents, reports	2019-10-08 14:19:01
Update on potential data sources with RWE data in Europe	Documents, reports	2019-10-08 14:18:53
Initial set of communication tools	Documents, reports	2019-10-08 14:19:01
First list of priority Real World Evidence relevant outcomes for AD	Documents, reports	2019-10-08 14:19:04
First report on proof of concept technical solutions for RWE data harmonisation and integration	Documents, reports	2019-10-08 14:18:47
Project website	Websites, patent fillings, videos etc.	2019-10-08 14:19:01
Final report on requirements for ELSI framework for a RWE approach in AD	Documents, reports	2019-10-08 14:19:02
Landscaping paper on ethics of outcome prioritisation in AD treatment	Documents, reports	2019-10-08 14:19:04
Structured review of existing C-E models and evidence	Documents, reports	2019-10-08 14:18:59
Final report on proof of concept technical solutions for RWE data harmonisation and integration	Documents, reports	2019-10-08 14:18:59
Brief on findings of ELSI focus groups for RWE approach to AD	Documents, reports	2019-10-08 14:19:02
Catalogue of RWE relevant AD models and simplistic disease stage framework	Documents, reports	2019-10-08 14:19:02
Report of systematic review of published an unpublished data identifying important and relevant outcomes in AD and criteria for disease progression	Documents, reports	2019-10-08 14:19:04
Overview of potential data sources with RWE data in Europe	Documents, reports	2019-10-08 14:18:48
Summary of gaps between data requirements and currently available data	Documents, reports	2019-10-08 14:18:40
Interim report on the EXAG activities and outputs	Documents, reports	2019-10-08 14:18:59
Review of ELSI issues in RWE approach	Documents, reports	2019-10-08 14:19:01
Report on results from â€˜hypothesis-freeâ€™ disease trajectory analyses	Documents, reports	2019-10-08 14:18:59
RWE progression marker and outcome classification matrix for AD	Documents, reports	2019-10-08 14:18:36
Recommendations for the development/interpretation of RWE AD models	Documents, reports	2019-07-25 18:35:48
Mapping algorithms from real world outcomes to preference-based measures	Documents, reports	2019-07-25 18:35:48
Selection of appropriate disease models for validation	Documents, reports	2019-07-25 18:35:48
Proof of concept AD C-E model	Documents, reports	2019-07-25 18:35:48
Guidelines for combining RCT, cohort, and EHR-based data for RWE in AD	Documents, reports	2019-07-25 18:35:48
Report on results from pilot model validation exercises	Documents, reports	2019-07-25 18:35:48
Guiding principles and recommendations for the development and incorporation of RWE into clinical and market access development plans for AD	Documents, reports	2019-07-25 18:35:49
Guidelines for use of smart devices as a measure of RWE	Documents, reports	2019-07-25 18:35:48
Paper on the regulatory and HTA experience with AD-approved products	Documents, reports	2019-07-25 18:35:48
Report on results from analysis of pharmacological interventions	Documents, reports	2019-07-25 18:35:49

Take a look to the deliverables list in detail: detailed list of ROADMAP deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2017	SzÃ³cska, MiklÃ³s and Jayawardana, Sahan and Smand, Carin and Salimullah, Tayyab and Reed, Catherine and Hanif, Shahid Big data for better outcomes: supporting health care system transformation in Europe published pages: , ISSN: 1356-1030, DOI:	EUROHEALTH	2019-07-25
2018	Jacoline C. Bouvy, Pall Jonsson, Diana Oâ€™Rourke, Antonella Santuccione Chadha, Niklas Hedberg, Amr Makady, Entela Xoxi, Christine Gispen-de Wied, Anja Schiel, Raj Long, John Gallacher Regulatory and Health Technology Assessment Considerations for Disease-Modifying Drugs in Alzheimerâ€™s Disease published pages: 1085-1090, ISSN: 1172-7047, DOI: 10.1007/s40263-018-0581-x	CNS Drugs 32/12	2019-07-25
2019	Claire Tochel, Michael Smith, Helen Baldwin, Anders Gustavsson, Amanda Ly, Christin Bexelius, Mia Nelson, Christophe Bintener, Enrico Fantoni, Josep Garre-Olmo, Olin Janssen, Christoph Jindra, Isabella F. JÃ¸rgensen, Alex McKeown, Buket Ã–ztÃ¼rk, Anna Ponjoan, Michele H. Potashman, Catherine Reed, Emilse Roncancio-Diaz, Stephanie Vos, Cathie Sudlow What outcomes are important to patients with mild cognitive impairment or Alzheimer\'s disease, their caregivers, and health-care professionals? AÂ systematic review published pages: 231-247, ISSN: 2352-8729, DOI: 10.1016/j.dadm.2018.12.003	Alzheimer\'s & Dementia: Diagnosis, Assessment & Disease Monitoring 11	2019-07-25
2019	Zuzanna Angehrn, Clementine Nordon, Andrew Turner, Dianne Gove, Helene Karcher, Alexander Keenan, Monika Neumann, Jelena Sostar, Frederic de Reydet de Vulpillieres Ethical and social implications of using predictive modeling for Alzheimerâ€™s disease prevention: a systematic literature review protocol published pages: e026468, ISSN: 2044-6055, DOI: 10.1136/bmjopen-2018-026468	BMJ Open 9/3	2019-07-25
2019	Anna Ponjoan, Josep Garre-Olmo, Jordi Blanch, Ester Fages, Lia Alves-Cabratosa, Ruth MartÃ-Lluch, Marc Comas-CufÃ, DÃdac Parramon, MarÃa Garcia-Gil, Rafel Ramos Epidemiology of dementia: prevalence and incidence estimates using validated electronic health records from primary care published pages: 217-228, ISSN: 1179-1349, DOI: 10.2147/clep.s186590	Clinical Epidemiology Volume 11	2019-07-25

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