RACE SIGNED
Rheumatoid Arthritis Caught Early: investigating biological mechanisms preceding chronification of joint inflammation to identify patients prior to presentation of classic chronic arthritis
Total Cost €
0EC-Contrib. €
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Project "RACE" data sheet
The following table provides information about the project.
| Coordinator |
ACADEMISCH ZIEKENHUIS LEIDEN
Organization address contact info |
| Coordinator Country | Netherlands [NL] |
| Total cost | 1˙500˙000 € |
| EC max contribution | 1˙500˙000 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2016-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-10-01 to 2022-09-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | ACADEMISCH ZIEKENHUIS LEIDEN | NL (LEIDEN) | coordinator | 1˙500˙000.00 |
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Project objective
Rheumatoid Arthritis (RA) causes long lasting disability. At the time of clinically evident arthritis and diagnosis, the disease is already persisting, requiring long-term suppressive treatment. My overarching aim is to prevent chronic arthritis and RA by inhibiting the evolving auto-immune response in a pre-arthritis phase. Currently, identification of RA-patients before the classic presentation with clinically evident chronic arthritis is beyond the state of the art. I here aim to achieve this early recognition by increasing the mechanistic understanding of pre-arthritis phases. I intend to study RA-specific auto-immune responses at the cellular and humoral level as well as markers reflecting local and systemic inflammation. These aspects are selected based on my world-wide validated rule to predict RA-development in early arthritis and on recent work on progression from Clinically Suspect Arthralgia (CSA) to clinical arthritis.
This project is now finally feasible, thanks to unique ‘pre-RA’ cohorts and cross-boundary preparatory work done with basic scientists, clinicians and engineers. My research concept is to integrate the products of separate trajectories in a longitudinal study and translate it to the clinic.
Patients with CSA will be studied serially in time. Using validated methods and novel techniques and insights we will: delineate molecular and predictive features of RA-specific auto-antibodies and auto-antibody secreting B-cells, identify improved markers of systemic inflammation and test and validate a computer-aided image analysis system to detect subclinical joint inflammation on MRI. Serial data will be combined to reveal interactions between markers and time relationships. Lastly a prediction model identifying imminent RA will be developed. The forefront position of my group allows national and international validation.
Together, this multidisciplinary and intersectorial project will open new horizons for preventive, targeted interventions.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
Aleid C Boer, Debbie M Boeters, Annette H M van der Helm-van Mil The use of MRI-detected synovitis to determine the number of involved joints for the 2010 ACR/EULAR classification criteria for Rheumatoid Arthritis – is it of additional benefit? published pages: annrheumdis-2018, ISSN: 0003-4967, DOI: 10.1136/annrheumdis-2018-213143 |
Annals of the Rheumatic Diseases | 2019-05-22 |
| 2019 |
Sarah Ohrndorf, Aleid C. Boer, Debbie M. Boeters, Robin M. ten Brinck, Gerd-R. Burmester, Marion C. Kortekaas, Annette H. M. van der Helm-van Mil Do musculoskeletal ultrasound and magnetic resonance imaging identify synovitis and tenosynovitis at the same joints and tendons? A comparative study in early inflammatory arthritis and clinically suspect arthralgia published pages: , ISSN: 1478-6362, DOI: 10.1186/s13075-019-1824-z |
Arthritis Research & Therapy 21/1 | 2019-05-22 |
| 2018 |
L. E. Burgers, D. M. Boeters, M. Reijnierse, A. H. M. van der Helm-van Mil Does the presence of magnetic resonance imaging-detected osteitis at diagnosis with rheumatoid arthritis lower the risk for achieving disease-modifying antirheumatic drug-free sustained remission: results of a longitudinal study published pages: , ISSN: 1478-6362, DOI: 10.1186/s13075-018-1553-8 |
Arthritis Research & Therapy 20/1 | 2019-05-22 |
| 2018 |
Robin M ten Brinck, Bastiaan T van Dijk, Hanna W van Steenbergen, Saskia le Cessie, Mattijs E Numans, Samantha L Hider, Christian Mallen, Annette van der Helm-van Mil Development and validation of a clinical rule for recognition of early inflammatory arthritis published pages: e023552, ISSN: 2044-6055, DOI: 10.1136/bmjopen-2018-023552 |
BMJ Open 8/11 | 2019-05-22 |
| 2017 |
Robin M. ten Brinck, Hanna W. van Steenbergen, Myrthe A. M. van Delft, Marije K. Verheul, Rene E. M. Toes, Leendert A. Trouw, Annette H. M. van der Helm – van Mil The risk of individual autoantibodies, autoantibody combinations and levels for arthritis development in clinically suspect arthralgia published pages: 2145-2153, ISSN: 1462-0324, DOI: 10.1093/rheumatology/kex340 |
Rheumatology 56/12 | 2019-05-22 |
| 2018 |
Aleid C Boer, Tom W J Huizinga, Annette H M van der Helm-van Mil Depression and anxiety associate with less remission after 1 year in rheumatoid arthritis published pages: e1-e1, ISSN: 0003-4967, DOI: 10.1136/annrheumdis-2017-212867 |
Annals of the Rheumatic Diseases 78/1 | 2019-05-22 |
| 2018 |
Aleid C. Boer, Annelies Boonen, Annette H. M. van der Helm van Mil Is Anti-Citrullinated Protein Antibody-Positive Rheumatoid Arthritis Still a More Severe Disease Than Anti-Citrullinated Protein Antibody-Negative Rheumatoid Arthritis? A Longitudinal Cohort Study in Rheumatoid Arthritis Patients Diagnosed From 2000 Onwar published pages: 987-996, ISSN: 2151-464X, DOI: 10.1002/acr.23497 |
Arthritis Care & Research 70/7 | 2019-05-22 |
| 2018 |
Debbie M. Boeters, Leendert A. Trouw, Annette H. M. van der Helm-van Mil, Hanna W. van Steenbergen Does information on novel identified autoantibodies contribute to predicting the progression from undifferentiated arthritis to rheumatoid arthritis: a study on anti-CarP antibodies as an example published pages: , ISSN: 1478-6362, DOI: 10.1186/s13075-018-1591-2 |
Arthritis Research & Therapy 20/1 | 2019-05-22 |
| 2018 |
Aleid C. Boer, Robin M. ten Brinck, Andrea W. M. Evers, Annette H. M. van der Helm-van Mil Does psychological stress in patients with clinically suspect arthralgia associate with subclinical inflammation and progression to inflammatory arthritis? published pages: , ISSN: 1478-6362, DOI: 10.1186/s13075-018-1587-y |
Arthritis Research & Therapy 20/1 | 2019-05-22 |
| 2018 |
R. M. ten Brinck, H. W. van Steenbergen, A. H. M. van der Helm–van Mil Sequence of joint tissue inflammation during rheumatoid arthritis development published pages: , ISSN: 1478-6362, DOI: 10.1186/s13075-018-1756-z |
Arthritis Research & Therapy 20/1 | 2019-05-22 |
| 2018 |
Yousra J Dakkak, Désirée M van der Heijde, Monique Reijnierse, Annette H M van der Helm-van Mil Validity of the rheumatoid arthritis MRI score applied to the forefeet using the OMERACT filter: a systematic literature review published pages: e000796, ISSN: 2056-5933, DOI: 10.1136/rmdopen-2018-000796 |
RMD Open 4/2 | 2019-05-22 |
| 2018 |
Leonie E Burgers, Robin M ten Brinck, Annette H M van der Helm-van Mil Is joint pain in patients with arthralgia suspicious for progression to rheumatoid arthritis explained by subclinical inflammation? A cross-sectional MRI study published pages: 86-93, ISSN: 1462-0324, DOI: 10.1093/rheumatology/key220 |
Rheumatology 58/1 | 2019-05-22 |
| 2018 |
R. M. ten Brinck, R. E. M. Toes, A. H. M. van der Helm–van Mil Inflammation functions as a key mediator in the link between ACPA and erosion development: an association study in Clinically Suspect Arthralgia published pages: , ISSN: 1478-6362, DOI: 10.1186/s13075-018-1574-3 |
Arthritis Research & Therapy 20/1 | 2019-05-22 |
| 2019 |
Y. J. Dakkak, D. M. Boeters, A. C. Boer, M. Reijnierse, A. H. M. van der Helm-van Mil What is the additional value of MRI of the foot to the hand in undifferentiated arthritis to predict rheumatoid arthritis development? published pages: , ISSN: 1478-6362, DOI: 10.1186/s13075-019-1845-7 |
Arthritis Research & Therapy 21/1 | 2019-05-22 |
| 2018 |
Debbie M Boeters, Wouter P Nieuwenhuis, Hanna W van Steenbergen, Monique Reijnierse, Robert B M Landewé, Annette H M van der Helm-van Mil Are MRI-detected erosions specific for RA? A large explorative cross-sectional study published pages: annrheumdis-2017, ISSN: 0003-4967, DOI: 10.1136/annrheumdis-2017-212252 |
Annals of the Rheumatic Diseases | 2019-05-22 |
| 2018 |
Debbie M Boeters, Aleid C Boer, Annette H M van der Helm-van Mil Evaluation of the predictive accuracy of MRI-detected erosions in hand and foot joints in patients with undifferentiated arthritis published pages: 144-146, ISSN: 0003-4967, DOI: 10.1136/annrheumdis-2018-213851 |
Annals of the Rheumatic Diseases 78/1 | 2019-05-22 |
| 2017 |
Debbie M Boeters, Karim Raza, Annette H M vander Helm-van Mil Which patients presenting with arthralgia eventually develop rheumatoid arthritis? The current state of the art published pages: e000479, ISSN: 2056-5933, DOI: 10.1136/rmdopen-2017-000479 |
RMD Open 3/2 | 2019-05-22 |
| 2017 |
Hanna W. van Steenbergen, José A. Pereira da Silva, Tom W. J. Huizinga, Annette H. M. van der Helm-van Mil Preventing progression from arthralgia to arthritis: targeting the right patients published pages: 32-41, ISSN: 1759-4790, DOI: 10.1038/nrrheum.2017.185 |
Nature Reviews Rheumatology 14/1 | 2019-05-22 |
| 2018 |
Robin M ten Brinck, Hanna W van Steenbergen, Annette H M van der Helm-van Mil Development of clinically apparent synovitis: a longitudinal study at the joint level during progression to inflammatory arthritis published pages: e000748, ISSN: 2056-5933, DOI: 10.1136/rmdopen-2018-000748 |
RMD Open 4/2 | 2019-05-22 |
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