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MechanoSystems SIGNED

How to build a brain? Engineering molecular systems for mechanosensation and -protection in neurons

Total Cost €

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EC-Contrib. €

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Partnership

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 MechanoSystems project word cloud

Explore the words cloud of the MechanoSystems project. It provides you a very rough idea of what is the project "MechanoSystems" about.

deformations    failures    live    forces    peripheral    small    molecular    expertise    mechanics    mechanosensation    shape    gap    influence    central    biomechanics    connections    signals    sense    dementias    cytoskeleton    little    stresses    dynamic    physiology    modeling    disease    chaperones    prognosis    microfluidic    human    injury    linked    mathematical    treat    nervous    broadly    spinal    therapies    aging    intractable    cells    optogenetic    neurons    nerve    involve    environments    observations    pathological    damage    yield    organism    pave    elegans    cord    deform    detecting    diseases    lab    prosthetic    movements    cope    levels    mechanoprotection    integrate    transmitted    living    diseased    synaptic    touch    visualize    force    mechanoreceptors    designed    function    sound    tools    poor    neuropathies    strategies    limit    transformations    protein    specialized    organisms    ubiquitous    transmission    cell    neurodegenerative    caenorhabditis    envision    signaling    mechanical    imaging    material    critical    neuronal   

Project "MechanoSystems" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT DE CIENCIES FOTONIQUES 

Organization address
address: AVINGUDA CARL FRIEDRICH GAUSS 3
city: Castelldefels
postcode: 8860
website: www.icfo.eu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 1˙829˙288 €
 EC max contribution 1˙829˙288 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2022-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT DE CIENCIES FOTONIQUES ES (Castelldefels) coordinator 1˙829˙288.00

Map

 Project objective

Mechanical forces are ubiquitous signals that provide critical and dynamic information about the environments around cells and organisms. Signals about touch, sound, and movements are transmitted to specialized mechanoreceptors but also deform the neuronal cytoskeleton of the central nervous system, particularly when strong forces are involved. Although failures to sense and cope with stresses are linked to human diseases including peripheral neuropathies and dementias, little is known about the connections between biomechanics and disease. A major reason for this gap is the technical challenge of detecting forces and deformations within a living cell or organism. Given the poor prognosis associated with neurodegenerative diseases, spinal cord injury and neuropathies, there is a strong need to develop a better understanding of neuronal mechanics.

In the proposed work, we will define the changes in protein mechanics that contribute to pathological transformations in mechanosensation and mechanoprotection by developing a systems-level understanding of these processes in Caenorhabditis elegans. My lab will exploit our expertise in force application using microfluidic devices and state-of-the-art imaging to visualize mechanical forces in live cells during mechanosensation (Aim 1). We will integrate our observations with mathematical modeling to yield insight into how changes in material properties influence cell shape and physiology during aging of an organism (Aim 2). Over the long term, we will develop new strategies to limit mechanical damage in aging neurons using small protein chaperones and design a prosthetic optogenetic synaptic-transmission system to maintain neuronal signaling in diseased conditions (Aim 3). Broadly, I envision that the knowledge and tools designed in this work will pave the way for the development of future therapies to treat currently intractable diseases that involve changes in nerve-cell function on the molecular and systems levels.

 Publications

year authors and title journal last update
List of publications.
2019 Gisela Cabré, Aida Garrido-Charles, Miquel Moreno, Miquel Bosch, Montserrat Porta-de-la-Riva, Michael Krieg, Marta Gascón-Moya, Núria Camarero, Ricard Gelabert, José M. Lluch, Félix Busqué, Jordi Hernando, Pau Gorostiza, Ramon Alibés
Rationally designed azobenzene photoswitches for efficient two-photon neuronal excitation
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-08796-9
Nature Communications 10/1 2019-12-16
2018 Holger Fehlauer, Adam L. Nekimken, Anna A. Kim, Beth L. Pruitt, Miriam B. Goodman, Michael Krieg
Using a Microfluidics Device for Mechanical Stimulation and High Resolution Imaging of C. elegans
published pages: , ISSN: 1940-087X, DOI: 10.3791/56530
Journal of Visualized Experiments 132 2019-12-16
2019 Liping He, Sarun Gulyanon, Mirna Mihovilovic Skanata, Doycho Karagyozov, Ellie S. Heckscher, Michael Krieg, Gavriil Tsechpenakis, Marc Gershow, W. Daniel Tracey
Direction Selectivity in Drosophila Proprioceptors Requires the Mechanosensory Channel Tmc
published pages: 945-956.e3, ISSN: 0960-9822, DOI: 10.1016/j.cub.2019.02.025
Current Biology 29/6 2019-12-16

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