#	Pagina
attuale pagina	/open-h2020/projects/209694/index.html

Opendata, web and dolomites

LABEL-DIOX

Late-stage catalytic carboxylation techniques with labelled carbon dioxide: new opportunities for radiolabelling

Total Cost €

EC-Contrib. €

Partnership

Views

LABEL-DIOX project word cloud

Explore the words cloud of the LABEL-DIOX project. It provides you a very rough idea of what is the project "LABEL-DIOX" about.

performed disposal carbon opportunity organisms behaves excretion labeled event dramatically data abundant syntheses decision metabolism expensive blocks diox sensitive delaying invaluable acute synthesis rely radiolabelled efficiency moisture privileged terminated reduce version motifs sequences building chemists living protocol 14c agrochemicals acids changing carboxylic label co2 pharmaceuticals operates understand catalysts industrial consideration earth discovery revenues myriad radiolabelling carboxylation offers drug drugs lengthy waste nor isotope air mild stage absorption ed utilizes labelled incorporation components conduct adme unfortunately minimize containing preclinical

Project "LABEL-DIOX" data sheet

The following table provides information about the project.

Coordinator	FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA Organization address address: AVENIDA PAISSOS CATALANS 16 city: TARRAGONA postcode: 43007 website: www.iciq.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	149˙750 €
EC max contribution	149˙750 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2016-PoC
Funding Scheme	ERC-POC
Starting year	2017
Duration (year-month-day)	from 2017-12-01 to 2019-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA Organization address address: AVENIDA PAISSOS CATALANS 16 city: TARRAGONA postcode: 43007 website: www.iciq.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (TARRAGONA)	coordinator	149˙750.00

Map

Project objective

Absorption, distribution, metabolism and excretion´s studies (ADME) are essential for drug discovery and development, providing invaluable preclinical data to understand how the drug behaves in living organisms, thus allowing to make a decision on whether the drug should be terminated or advanced to the next step. At present, most of these studies are performed with a radiolabelled 14C-labelled version of the drug; unfortunately, current radiolabelling syntheses rely on lengthy-step sequences or rather expensive 14C-labelled building blocks, dramatically raising the costs for the research and development, and delaying the execution of preclinical studies. Taking into consideration that carboxylic acids are privileged motifs in a myriad of agrochemicals or pharmaceuticals, LABEL-DIOX offers the opportunity of promoting a late-stage carboxylation event with labeled CO2. The protocol is user-friendly, with components that are neither air- nor moisture sensitive, utilizes earth-abundant catalysts and operates under mild conditions. LABEL-DIOX will increase the overall efficiency of the carbon isotope incorporation, reduce the costs that would have resulted from the design of a lengthy radiolabelled synthesis, minimize the costs for waste disposal and dramatically increase the revenues, thus changing the way industrial chemists conduct radiolabelling of drugs containing carboxylic acids.

Publications

List of publications.
year	authors and title	journal	last update
2019	Andreu Tortajada, Yaya Duan, Basudev Sahoo, Fei Cong, Georgios Toupalas, Antoine Sallustrau, Olivier Loreau, Davide Audisio, Ruben Martin Catalytic Decarboxylation/Carboxylation Platform for Accessing Isotopically Labeled Carboxylic Acids published pages: 5897-5901, ISSN: 2155-5435, DOI: 10.1021/acscatal.9b01921	ACS Catalysis 9/7	2019-11-26

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "LABEL-DIOX" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "LABEL-DIOX" are provided by the European Opendata Portal: CORDIS opendata.