Explore the words cloud of the IMPRiND project. It provides you a very rough idea of what is the project "IMPRiND" about.
The following table provides information about the project.
Coordinator |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Organization address contact info |
Coordinator Country | United Kingdom [UK] |
Project website | http://imprind.org/ |
Total cost | 11˙363˙398 € |
EC max contribution | 4˙684˙998 € (41%) |
Programme |
1. H2020-EU.3.1.7. (Innovative Medicines Initiative 2 (IMI2)) |
Code Call | H2020-JTI-IMI2-2015-07-two-stage |
Funding Scheme | IMI2-RIA |
Starting year | 2017 |
Duration (year-month-day) | from 2017-03-01 to 2021-02-28 |
Take a look of project's partnership.
Assemblies of tau and α-synuclein were shown to spread along interconnected neuronal networks suggesting broadly relevant therapeutic directions for Alzheimer’s and Parkinson’s disease. This requires a pre-clinical stage of development that has yet to be met. The scale of neurodegenerative disease burden in Europe calls for an unprecedented research effort that can only be achieved through collaboration between leading European laboratories and the pharmaceutical industry. To meet this ambition the IMPRiND consortium will synergistically accelerate progress to map and target critical steps in the propagation, proteostatic response and protection against misfolded α-synuclein and tau. Specifically we aim to (1) identify disease-relevant assemblies, imprint their biological properties in vitro and generate homogeneous populations to assay and interfere with their pathogenic effects; (2) develop and miniaturise assays to monitor secretion, uptake, clearance and oligomerisation using bimolecular fluorescence complementation of oligomeric species or transfer of untagged assemblies to fluorescently labelled fibril-naïve cells and measure markers of early proteotoxicity that are suitable for live imaging high content screens; (3) deliver robust validation assays for these molecular events in complex cellular systems with greater functional resemblance to the native milieu of the brain such as iPSC-based and organotypic cultures (4) standardise pathological readouts in animal models for in vivo validation of modifiers, correlate them with novel peripheral or in situ markers using microdialysis to accelerate the assessment of therapeutic interventions and relevance to humans, e.g. by transplantation of human iPSC neurons in animals; (5) assess toxicity and druggability of potential targets. IMPRiND will construct this entire pipeline to examine the prion-like properties of α-synuclein and tau and test their tractability against disease progression.
Launch of website, Twitter and other dissemination activities | Documents, reports | 2020-01-22 14:45:24 |
Press release | Documents, reports | 2020-01-22 14:45:24 |
Take a look to the deliverables list in detail: detailed list of IMPRiND deliverables.
year | authors and title | journal | last update |
---|---|---|---|
2019 |
Parvez Alam, Luc Bousset, Ronald Melki, Daniel E. Otzen αâ€synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities published pages: 522-534, ISSN: 0022-3042, DOI: 10.1111/jnc.14808 |
Journal of Neurochemistry 150/5 | 2020-04-01 |
2019 |
Audrey Chabrat, Emmanuelle Lacassagne, Rodolphe Billiras, Sophie Landron, Amélie Pontisso-Mahout, Hélène Darville, Alain Dupront, Francis Coge, Esther Schenker, David Piwnica, Emmanuel Nivet, François Féron, Clotilde Mannoury la Cour Pharmacological Transdifferentiation of Human Nasal Olfactory Stem Cells into Dopaminergic Neurons published pages: 1-15, ISSN: 1687-966X, DOI: 10.1155/2019/2945435 |
Stem Cells International 2019 | 2020-04-01 |
2019 |
Taxiarchis Katsinelos, Benjamin J. Tuck, Aamir S. Mukadam, William A. McEwan The Role of Antibodies and Their Receptors in Protection Against Ordered Protein Assembly in Neurodegeneration published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.01139 |
Frontiers in Immunology 10 | 2020-04-01 |
2019 |
Leonidas Stefanis, Evangelia Emmanouilidou, Marina Pantazopoulou, Deniz Kirik, Kostas Vekrellis, George K. Tofaris How is alphaâ€synuclein cleared from the cell? published pages: 577-590, ISSN: 0022-3042, DOI: 10.1111/jnc.14704 |
Journal of Neurochemistry 150/5 | 2020-04-01 |
2020 |
Josquin Courte, Luc Bousset, Ysander Von Boxberg, Catherine Villard, Ronald Melki, Jean-Michel Peyrin The expression level of alpha-synuclein in different neuronal populations is the primary determinant of its prion-like seeding published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-020-61757-x |
Scientific Reports 10/1 | 2020-04-01 |
2019 |
Guerrero-Ferreira, Ricardo; Taylor, Nicholas MI; Arteni, Ana-Andreea; Kumari, Pratibha; Mona, Daniel; Ringler, Philippe; Britschgi, Markus; Lauer, Matthias E; Makky, Ali; Verasdonck, Joeri; Riek, Roland; Melki, Ronald; Meier, Beat H; Böckmann, Anja; Bousset, Luc; Stahlberg, Henning Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy published pages: , ISSN: 2050-084X, DOI: 10.3929/ethz-b-000391777 |
EISSN: 2050-084X 1 | 2020-04-01 |
2020 |
Francesca De Giorgi, Florent Laferrière, Federica Zinghirino, Emilie Faggiani, Alons Lends, Mathilde Bertoni, Xuan Yu, Axelle Grélard, Estelle Morvan, Birgit Habenstein, Nathalie Dutheil, Evelyne Doudnikoff, Jonathan Daniel, Stéphane Claverol, Chuan Qin, Antoine Loquet, Erwan Bezard, François Ichas Emergence of stealth polymorphs that escape α-synuclein amyloid monitoring, take over and acutely spread in neurons published pages: , ISSN: 2041-1723, DOI: 10.1101/2020.02.11.943670 |
Nature Comunication | 2020-04-01 |
2020 |
Amulya Nidhi Shrivastava, Luc Bousset, Marianne Renner, Virginie Redeker, Jimmy Savistchenko, Antoine Triller, Ronald Melki Differential Membrane Binding and Seeding of Distinct α-Synuclein Fibrillar Polymorphs published pages: , ISSN: 0006-3495, DOI: 10.1016/j.bpj.2020.01.022 |
Biophysical Journal | 2020-04-01 |
2019 |
Wenjuan Zhang, Benjamin Falcon, Alexey G Murzin, Juan Fan, R Anthony Crowther, Michel Goedert, Sjors HW Scheres Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases published pages: , ISSN: 2050-084X, DOI: 10.1101/468892 |
Elife | 2020-04-01 |
2019 |
Nolwen L. Rey, Luc Bousset, Sonia George, Zachary Madaj, Lindsay Meyerdirk, Emily Schulz, Jennifer A. Steiner, Ronald Melki, Patrik Brundin α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb published pages: , ISSN: 2051-5960, DOI: 10.1186/s40478-019-0859-3 |
Acta Neuropathologica Communications 7/1 | 2020-04-01 |
2020 |
Antonio Dominguez-Meijide1, Eftychia Vasili, Annekatrin König, Maria-Sol Cima-Omori, Andrei Leonov, Sergey Ryazanov, Markus Zweckstetter, Christian Griesinger, Tiago F. Outeiro Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization published pages: , ISSN: , DOI: 10.1101/2020.01.27.921643 |
2020-04-01 | |
2019 |
Alexis Fenyi, Laurène Leclair-Visonneau, Thomas Clairembault, Emmanuel Coron, Michel Neunlist, Ronald Melki, Pascal Derkinderen, Luc Bousset Detection of alpha-synuclein aggregates in gastrointestinal biopsies by protein misfolding cyclic amplification published pages: 38-43, ISSN: 0969-9961, DOI: 10.1016/j.nbd.2019.05.002 |
Neurobiology of Disease 129 | 2020-04-01 |
2020 |
Wenjuan Zhang, Airi Tarutani, Kathy L. Newell, Alexey G. Murzin, Tomoyasu Matsubara, Benjamin Falcon, Ruben Vidal, Holly J. Garringer, Yang Shi, Takeshi Ikeuchi, Shigeo Murayama, Bernardino Ghetti, Masato Hasegawa, Michel Goedert, Sjors H.W. Scheres Novel tau filament fold in corticobasal degeneration, a four-repeat tauopathy published pages: , ISSN: 2041-1723, DOI: 10.1101/811703 |
Nature | 2020-04-01 |
2018 |
Alexis Fenyi, Audrey Coens, Tracy Bellande, Ronald Melki, Luc Bousset Assessment of the efficacy of different procedures that remove and disassemble alpha-synuclein, tau and A-beta fibrils from laboratory material and surfaces published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-28856-2 |
Scientific Reports 8/1 | 2020-01-22 |
2019 |
Panagiota Mavroeidi, Fedra Arvanitaki, Anastasia-Kiriaki Karakitsou, Maria Vetsi, Ismini Kloukina, Markus Zweckstetter, Karin Giller, Stefan Becker, Zachary A. Sorrentino, Benoit I. Giasson, Poul Henning Jensen, Leonidas Stefanis, Maria Xilouri Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models published pages: , ISSN: 0001-6322, DOI: 10.1007/s00401-019-02014-y |
Acta Neuropathologica | 2020-01-22 |
2019 |
Eftychia Vasili, Antonio Dominguez-Meijide, Tiago Fleming Outeiro Spreading of α-Synuclein and Tau: A Systematic Comparison of the Mechanisms Involved published pages: , ISSN: 1662-5099, DOI: 10.3389/fnmol.2019.00107 |
Frontiers in Molecular Neuroscience 12 | 2020-01-22 |
2019 |
Gregor Bieri, Michel Brahic, Luc Bousset, Julien Couthouis, Nicholas J. Kramer, Rosanna Ma, Lisa Nakayama, Marie Monbureau, Erwin Defensor, Birgitt Schüle, Mehrdad Shamloo, Ronald Melki, Aaron D. Gitler LRRK2 modifies α-syn pathology and spread in mouse models and human neurons published pages: , ISSN: 0001-6322, DOI: 10.1007/s00401-019-01995-0 |
Acta Neuropathologica | 2020-01-22 |
2018 |
Benjamin Falcon, Wenjuan Zhang, Alexey G. Murzin, Garib Murshudov, Holly J. Garringer, Ruben Vidal, R. Anthony Crowther, Bernardino Ghetti, Sjors H. W. Scheres, Michel Goedert Structures of filaments from Pick’s disease reveal a novel tau protein fold published pages: 137-140, ISSN: 0028-0836, DOI: 10.1038/s41586-018-0454-y |
Nature 561/7721 | 2020-01-22 |
2018 |
Benjamin Falcon, Wenjuan Zhang, Manuel Schweighauser, Alexey G. Murzin, Ruben Vidal, Holly J. Garringer, Bernardino Ghetti, Sjors H. W. Scheres, Michel Goedert Tau filaments from multiple cases of sporadic and inherited Alzheimer’s disease adopt a common fold published pages: 699-708, ISSN: 0001-6322, DOI: 10.1007/s00401-018-1914-z |
Acta Neuropathologica 136/5 | 2020-01-22 |
2019 |
Amulya Nidhi Shrivastava, Virginie Redeker, Laura Pieri, Luc Bousset, Marianne Renner, Karine Madiona, Caroline Mailhesâ€Hamon, Audrey Coens, Luc Buée, Philippe Hantraye, Antoine Triller, Ronald Melki Clustering of Tau fibrils impairs the synaptic composition of α3â€Na + /K + â€ATPase and AMPA receptors published pages: e99871, ISSN: 0261-4189, DOI: 10.15252/embj.201899871 |
The EMBO Journal 38/3 | 2020-01-22 |
2019 |
Simona Gribaudo, Philippe Tixador, Luc Bousset, Alexis Fenyi, Patricia Lino, Ronald Melki, Jean-Michel Peyrin, Anselme L. Perrier Propagation of α-Synuclein Strains within Human Reconstructed Neuronal Network published pages: 230-244, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2018.12.007 |
Stem Cell Reports 12/2 | 2020-01-22 |
2018 |
Maria Grazia Spillantini, Michel Goedert Neurodegeneration and the ordered assembly of α-synuclein published pages: 137-148, ISSN: 0302-766X, DOI: 10.1007/s00441-017-2706-9 |
Cell and Tissue Research 373/1 | 2020-01-22 |
2018 |
Michel Goedert, Yoshiki Yamaguchi, Sushil K. Mishra, Makoto Higuchi, Naruhiko Sahara Tau Filaments and the Development of Positron Emission Tomography Tracers published pages: , ISSN: 1664-2295, DOI: 10.3389/fneur.2018.00070 |
Frontiers in Neurology 9 | 2020-01-22 |
2017 |
Anthony W. P. Fitzpatrick, Benjamin Falcon, Shaoda He, Alexey G. Murzin, Garib Murshudov, Holly J. Garringer, R. Anthony Crowther, Bernardino Ghetti, Michel Goedert, Sjors H. W. Scheres Cryo-EM structures of tau filaments from Alzheimer’s disease published pages: 185-190, ISSN: 0028-0836, DOI: 10.1038/nature23002 |
Nature 547/7662 | 2020-01-22 |
2017 |
George K. Tofaris A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson’s Disease published pages: 569-576, ISSN: 1877-7171, DOI: 10.3233/JPD-171176 |
Journal of Parkinson\'s Disease 7/4 | 2020-01-22 |
2018 |
Franziska Kundel, Liu Hong, Benjamin Falcon, William A. McEwan, Thomas C. T. Michaels, Georg Meisl, Noemi Esteras, Andrey Y. Abramov, Tuomas J. P. Knowles, Michel Goedert, David Klenerman Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading published pages: , ISSN: 1948-7193, DOI: 10.1021/acschemneuro.8b00094 |
ACS Chemical Neuroscience | 2020-01-22 |
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