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META-DORM SIGNED

Mechanobiology of METAstatic and DORMant cancer cells in bone marrow lesions

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

META-DORM project word cloud

Explore the words cloud of the META-DORM project. It provides you a very rough idea of what is the project "META-DORM" about.

balance mechanisms metastatic fatal types roles prevention form cells signalling persist prevent therapeutic cilium niche skeletal mechanically lesions usually individual significantly culturing observe survival poorly chemical homeostatic resistant effect stimulation implicated dormancy dormant cycle invaded remodelling warning hijacking active treatment physical suggests dramatically sites mechanosensor light tumours bone cancer mechanical once reside explore interactions cellular tumour shed resorption radiation environment chemotherapy decreases metastasis remission intriguingly normal plays will rates quiescent marrow reactivate first time months while cell primary chemosensing mechanobiological

Project "META-DORM" data sheet

The following table provides information about the project.

Coordinator	QUEEN MARY UNIVERSITY OF LONDON Organization address address: 327 MILE END ROAD city: LONDON postcode: E1 4NS website: http://www.qmul.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	https://stefaanverbruggen.com/
Total cost	183˙792 €
EC max contribution	183˙792 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-GF
Starting year	2018
Duration (year-month-day)	from 2018-01-01 to 2020-06-29

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	QUEEN MARY UNIVERSITY OF LONDON QUEEN MARY UNIVERSITY OF LONDON Organization address address: 327 MILE END ROAD city: LONDON postcode: E1 4NS website: http://www.qmul.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	183˙792.00
2	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK Organization address address: AMSTERDAM AVENUE 1210 ROOM city: NEW YORK postcode: 10027 7003 website: www.columbia.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (NEW YORK)	partner	0.00

Map

Project objective

While cancer survival rates have improved significantly in recent years, survival decreases dramatically after tumour metastasis. One of the most common sites for metastatic tumours to develop is bone. Intriguingly, evidence suggests that once they have invaded the bone marrow, individual metastatic cancer cells can persist for years in a quiescent or “dormant” state, and are resistant to both radiation and chemotherapy treatment. These dormant cells can reside for months or years while the cancer is in remission, and then “reactivate” without warning to form new, usually fatal, skeletal lesions. Tumour cells achieve this by “hijacking” the normal bone remodelling cycle, a homeostatic balance between bone formation and resorption, to form a metastatic niche within the marrow. However, the signalling mechanisms that cause metastasis and dormancy, particularly in such a mechanically active environment, are poorly understood. Therefore, the goal of this project is to investigate the chemical and physical interactions between bone and cancer cells, both during dormancy and mechanical stimulation, to provide new insight into bone metastatic lesions and explore novel therapeutic targets to prevent cancer metastasis. This will be achieved by culturing specific bone and cancer cell types together for the first time to observe changes in their signalling and behaviour. Dormancy will also be induced, to observe its effect on changes in signalling. Mechanical stimulation will be applied to investigate whether the complex mechanical environment of the bone marrow plays a role in cancer metastasis. Finally, a specific cellular mechanosensor, the primary cilium, which has been implicated in the development of cancer and is known to be involved in bone formation, will be investigated. This will shed new light on its chemosensing and mechanobiological roles in cancer metastasis, as well as explore its potential as a novel target for cancer treatment and prevention.

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The information about "META-DORM" are provided by the European Opendata Portal: CORDIS opendata.