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HoldCancerBack SIGNED

What Holds Cancer Cells Back?

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 HoldCancerBack project word cloud

Explore the words cloud of the HoldCancerBack project. It provides you a very rough idea of what is the project "HoldCancerBack" about.

genetic    idea    types    individual    alternative    biopsies    mre    bulk    perfect    follows    motile    breakthrough    question    stress    biomechanics    flow    fluid    signalling    overcoming    voronoi    since    vital    answer    interplay    yield    empower    detected    innovative    metastatic    bionic    tumour    live    material    intracellular    jamming    quantified    theories    guide    cell    molecular    exclusive    cellular    dense    progression    physics    actively    environments    predictive    unjamming    conventional    tackles    jammed    forces    surgery    me    model    elastography    diagram    collective    tissue    resonance    cells    speed    self    ecm    clusters    spv    microenvironment    mamma    matrix    spreading    mechanics    complement    contractility    cancer    magnetic    marker    prove    modulators    ground    surgeons    extracellular    propelled    local    imaging    carcinomas    metastasis    basic    neighbours    shape    cervix    tracking    transitions    introduce    unjammed    limitations    therapies    breaking    concerning    decades    adhesion    building    focusses    mechanisms    leadership    overcome   

Project "HoldCancerBack" data sheet

The following table provides information about the project.

Coordinator		 UNIVERSITAET LEIPZIG 

Organization address
address: RITTERSTRASSE 26
city: LEIPZIG
postcode: 4109
website: www.uni-Ieipzig.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Germany [DE]
 Project website http://home.uni-leipzig.de/pwm/web/content-ERC.htm
 Total cost 2˙379˙250 €
 EC max contribution 2˙379˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-08-01   to  2022-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET LEIPZIG DE (LEIPZIG) coordinator 2˙379˙250.00

Map

 Project objective

Since decades the bulk of cancer research focusses on the genetic and molecular level. To complement this knowledge, I will focus on the collective behaviour of cancer cells in cell clusters and in the extracellular matrix (ECM). Conventional cancer research tackles issues like genetic changes, signalling pathways or intracellular mechanisms, I want to answer the question: When is a cancer cell jammed or when can it overcome the yield stress to actively “flow” in a dense microenvironment (ME)? I have brought forward the basic idea within the concept of Physics of Cancer that changes in a cancer cell’s material properties determine its metastatic potential. As follows I propose the next breakthrough by determining a predictive phase diagram for unjamming transitions of cancer cells. Cancer cell jamming is quantified by cell speed as a measure of the motile forces and by cellular shape to account for the interplay between cell contractility and adhesion. Our self-propelled Voronoi model (SPV) will explain whether a cell is jammed by its neighbours or the ECM, overcoming the limitations of existing theories which only apply to specific environments. Building on my leadership in cell biomechanics and the exclusive access to two types of carcinomas (mamma, cervix), I will introduce highly innovative bionic modulators of intracellular mechanics and develop live cancer cell tracking in biopsies as a ground-breaking alternative to vital imaging. While these approaches are perfect to prove that unjamming transitions are key to tumour progression, I will investigate to what extent fluid, i.e. unjammed, tissue behaviour can be detected by magnetic resonance imaging elastography (MRE) as an individual predictive marker for metastasis. Moreover the results may guide surgeons when concerning the local spreading of cancer and thus greatly empower surgery in tumour therapies.

 Publications

year authors and title journal last update
List of publications.
2020 Jörg Schnauß, B.U. Sebastian Schmidt, Christina B. Brazel, Senol Dogan, Wolfgang Losert, Ulf Anderegg, Josef A. Käs
Influence of hyaluronic acid binding on the actin cortex measured by optical forces
published pages: e201960215, ISSN: 1864-063X, DOI: 10.1002/jbio.201960215 		Journal of Biophotonics 2020-04-24
2020 Paul Van Liedekerke, Johannes Neitsch, Tim Johann, Enrico Warmt, Ismael Gonzàlez-Valverde, Stefan Hoehme, Steffen Grosser, Josef Kaes, Dirk Drasdo
A quantitative high-resolution computational mechanics cell model for growing and regenerating tissues
published pages: 189-220, ISSN: 1617-7959, DOI: 10.1007/s10237-019-01204-7 		Biomechanics and Modeling in Mechanobiology 19/1 2020-04-15
2020 Kaspar-Josche Streitberger, Ledia Lilaj, Felix Schrank, Jürgen Braun, Karl-Titus Hoffmann, Martin Reiss-Zimmermann, Josef A. Käs, Ingolf Sack
How tissue fluidity influences brain tumor progression
published pages: 128-134, ISSN: 0027-8424, DOI: 10.1073/pnas.1913511116 		Proceedings of the National Academy of Sciences 117/1 2020-02-12
2019 Mehrgan Shahryari, Heiko Tzschätzsch, Jing Guo, Stephan R. Marticorena Garcia, Georg Böning, Uli Fehrenbach, Lisa Stencel, Patrick Asbach, Bernd Hamm, Joseph A. Käs, Jürgen Braun, Timm Denecke, Ingolf Sack
Tomoelastography Distinguishes Noninvasively between Benign and Malignant Liver Lesions
published pages: 5704-5710, ISSN: 0008-5472, DOI: 10.1158/0008-5472.can-19-2150 		Cancer Research 79/22 2020-02-12
2019 Carlotta Ficorella, Rebeca Martínez Vázquez, Paul Heine, Eugenia Lepera, Jing Cao, Enrico Warmt, Roberto Osellame, Josef A Käs
Normal epithelial and triple-negative breast cancer cells show the same invasion potential in rigid spatial confinement
published pages: 83016, ISSN: 1367-2630, DOI: 10.1088/1367-2630/ab3572 		New Journal of Physics 21/8 2019-12-17
2019 Hans Kubitschke, Benjamin Wolf, Erik Morawetz, Lars-Christian Horn, Bahriye Aktas, Ulrich Behn, Michael Höckel, Josef Käs
Roadmap to Local Tumour Growth: Insights from Cervical Cancer
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-49182-1 		Scientific Reports 9/1 2019-12-17
2019 Tom Golde, Martin Glaser, Cary Tutmarc, Iman Elbalasy, Constantin Huster, Gaizka Busteros, David M. Smith, Harald Herrmann, Josef A. Käs, Jörg Schnauß
The role of stickiness in the rheology of semiflexible polymers
published pages: 4865-4872, ISSN: 1744-683X, DOI: 10.1039/C9SM00433E 		Soft Matter 15/24 2019-09-09
2019 Frank Sauer, Linda Oswald, Angela Ariza de Schellenberger, Heiko Tzschätzsch, Felix Schrank, Tony Fischer, Jürgen Braun, Claudia Tanja Mierke, Rustem Valiullin, Ingolf Sack, Josef Alfons Käs
Collagen networks determine viscoelastic properties of connective tissues yet do not hinder diffusion of the aqueous solvent
published pages: 3055-3064, ISSN: 1744-683X, DOI: 10.1039/c8sm02264j 		Soft Matter 15/14 2019-06-11
2018 Felix Meinhövel, Roland Stange, Jörg Schnauß, Michael Sauer, Josef A Käs, Torsten W Remmerbach
Changing cell mechanics—a precondition for malignant transformation of oral squamous carcinoma cells
published pages: 34001, ISSN: 2057-1739, DOI: 10.1088/2057-1739/aac72d 		Convergent Science Physical Oncology 4/3 2019-03-18
2018 Claudia Tanja Mierke, Frank Sauer, Steffen Grosser, Stefanie Puder, Tony Fischer, Josef Alfons Käs
The two faces of enhanced stroma: Stroma acts as a tumor promoter and a steric obstacle
published pages: e3831, ISSN: 0952-3480, DOI: 10.1002/nbm.3831 		NMR in Biomedicine 31/10 2019-03-18
2018 Jessica S. Lorenz, Jörg Schnauß, Martin Glaser, Martin Sajfutdinow, Carsten Schuldt, Josef A. Käs, David M. Smith
Synthetic Transient Crosslinks Program the Mechanics of Soft, Biopolymer-Based Materials
published pages: 1706092, ISSN: 0935-9648, DOI: 10.1002/adma.201706092 		Advanced Materials 30/13 2019-03-18
2017 Linda Oswald, Steffen Grosser, David M Smith, Josef A Käs
Jamming transitions in cancer
published pages: 483001, ISSN: 0022-3727, DOI: 10.1088/1361-6463/aa8e83 		Journal of Physics D: Applied Physics 50/48 2019-03-18
2018 Tom Golde, Constantin Huster, Martin Glaser, Tina Händler, Harald Herrmann, Josef A. Käs, Jörg Schnauß
Glassy dynamics in composite biopolymer networks
published pages: 7970-7978, ISSN: 1744-683X, DOI: 10.1039/c8sm01061g 		Soft Matter 14/39 2019-03-18
2017 Dan Strehle, Paul Mollenkopf, Martin Glaser, Tom Golde, Carsten Schuldt, Josef A. Käs, Jörg Schnauß
Single Actin Bundle Rheology
published pages: 1804, ISSN: 1420-3049, DOI: 10.3390/molecules22101804 		Molecules 22/10 2019-03-18

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The information about "HOLDCANCERBACK" are provided by the European Opendata Portal: CORDIS opendata.

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