HoldCancerBack SIGNED
What Holds Cancer Cells Back?
Total Cost €
0EC-Contrib. €
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0HoldCancerBack project word cloud
Explore the words cloud of the HoldCancerBack project. It provides you a very rough idea of what is the project "HoldCancerBack" about.
Project "HoldCancerBack" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITAET LEIPZIG
Organization address contact info |
| Coordinator Country | Germany [DE] |
| Project website | http://home.uni-leipzig.de/pwm/web/content-ERC.htm |
| Total cost | 2˙379˙250 € |
| EC max contribution | 2˙379˙250 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2016-ADG |
| Funding Scheme | ERC-ADG |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-08-01 to 2022-07-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITAET LEIPZIG | DE (LEIPZIG) | coordinator | 2˙379˙250.00 |
Map
Project objective
Since decades the bulk of cancer research focusses on the genetic and molecular level. To complement this knowledge, I will focus on the collective behaviour of cancer cells in cell clusters and in the extracellular matrix (ECM). Conventional cancer research tackles issues like genetic changes, signalling pathways or intracellular mechanisms, I want to answer the question: When is a cancer cell jammed or when can it overcome the yield stress to actively “flow” in a dense microenvironment (ME)? I have brought forward the basic idea within the concept of Physics of Cancer that changes in a cancer cell’s material properties determine its metastatic potential. As follows I propose the next breakthrough by determining a predictive phase diagram for unjamming transitions of cancer cells. Cancer cell jamming is quantified by cell speed as a measure of the motile forces and by cellular shape to account for the interplay between cell contractility and adhesion. Our self-propelled Voronoi model (SPV) will explain whether a cell is jammed by its neighbours or the ECM, overcoming the limitations of existing theories which only apply to specific environments. Building on my leadership in cell biomechanics and the exclusive access to two types of carcinomas (mamma, cervix), I will introduce highly innovative bionic modulators of intracellular mechanics and develop live cancer cell tracking in biopsies as a ground-breaking alternative to vital imaging. While these approaches are perfect to prove that unjamming transitions are key to tumour progression, I will investigate to what extent fluid, i.e. unjammed, tissue behaviour can be detected by magnetic resonance imaging elastography (MRE) as an individual predictive marker for metastasis. Moreover the results may guide surgeons when concerning the local spreading of cancer and thus greatly empower surgery in tumour therapies.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2020 |
Jörg Schnauß, B.U. Sebastian Schmidt, Christina B. Brazel, Senol Dogan, Wolfgang Losert, Ulf Anderegg, Josef A. Käs Influence of hyaluronic acid binding on the actin cortex measured by optical forces published pages: e201960215, ISSN: 1864-063X, DOI: 10.1002/jbio.201960215 |
Journal of Biophotonics | 2020-04-24 |
| 2020 |
Paul Van Liedekerke, Johannes Neitsch, Tim Johann, Enrico Warmt, Ismael Gonzà lez-Valverde, Stefan Hoehme, Steffen Grosser, Josef Kaes, Dirk Drasdo A quantitative high-resolution computational mechanics cell model for growing and regenerating tissues published pages: 189-220, ISSN: 1617-7959, DOI: 10.1007/s10237-019-01204-7 |
Biomechanics and Modeling in Mechanobiology 19/1 | 2020-04-15 |
| 2020 |
Kaspar-Josche Streitberger, Ledia Lilaj, Felix Schrank, Jürgen Braun, Karl-Titus Hoffmann, Martin Reiss-Zimmermann, Josef A. Käs, Ingolf Sack How tissue fluidity influences brain tumor progression published pages: 128-134, ISSN: 0027-8424, DOI: 10.1073/pnas.1913511116 |
Proceedings of the National Academy of Sciences 117/1 | 2020-02-12 |
| 2019 |
Mehrgan Shahryari, Heiko Tzschätzsch, Jing Guo, Stephan R. Marticorena Garcia, Georg Böning, Uli Fehrenbach, Lisa Stencel, Patrick Asbach, Bernd Hamm, Joseph A. Käs, Jürgen Braun, Timm Denecke, Ingolf Sack Tomoelastography Distinguishes Noninvasively between Benign and Malignant Liver Lesions published pages: 5704-5710, ISSN: 0008-5472, DOI: 10.1158/0008-5472.can-19-2150 |
Cancer Research 79/22 | 2020-02-12 |
| 2019 |
Carlotta Ficorella, Rebeca MartÃnez Vázquez, Paul Heine, Eugenia Lepera, Jing Cao, Enrico Warmt, Roberto Osellame, Josef A Käs Normal epithelial and triple-negative breast cancer cells show the same invasion potential in rigid spatial confinement published pages: 83016, ISSN: 1367-2630, DOI: 10.1088/1367-2630/ab3572 |
New Journal of Physics 21/8 | 2019-12-17 |
| 2019 |
Hans Kubitschke, Benjamin Wolf, Erik Morawetz, Lars-Christian Horn, Bahriye Aktas, Ulrich Behn, Michael Höckel, Josef Käs Roadmap to Local Tumour Growth: Insights from Cervical Cancer published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-49182-1 |
Scientific Reports 9/1 | 2019-12-17 |
| 2019 |
Tom Golde, Martin Glaser, Cary Tutmarc, Iman Elbalasy, Constantin Huster, Gaizka Busteros, David M. Smith, Harald Herrmann, Josef A. Käs, Jörg Schnauß The role of stickiness in the rheology of semiflexible polymers published pages: 4865-4872, ISSN: 1744-683X, DOI: 10.1039/C9SM00433E |
Soft Matter 15/24 | 2019-09-09 |
| 2019 |
Frank Sauer, Linda Oswald, Angela Ariza de Schellenberger, Heiko Tzschätzsch, Felix Schrank, Tony Fischer, Jürgen Braun, Claudia Tanja Mierke, Rustem Valiullin, Ingolf Sack, Josef Alfons Käs Collagen networks determine viscoelastic properties of connective tissues yet do not hinder diffusion of the aqueous solvent published pages: 3055-3064, ISSN: 1744-683X, DOI: 10.1039/c8sm02264j |
Soft Matter 15/14 | 2019-06-11 |
| 2018 |
Felix Meinhövel, Roland Stange, Jörg Schnauß, Michael Sauer, Josef A Käs, Torsten W Remmerbach Changing cell mechanics—a precondition for malignant transformation of oral squamous carcinoma cells published pages: 34001, ISSN: 2057-1739, DOI: 10.1088/2057-1739/aac72d |
Convergent Science Physical Oncology 4/3 | 2019-03-18 |
| 2018 |
Claudia Tanja Mierke, Frank Sauer, Steffen Grosser, Stefanie Puder, Tony Fischer, Josef Alfons Käs The two faces of enhanced stroma: Stroma acts as a tumor promoter and a steric obstacle published pages: e3831, ISSN: 0952-3480, DOI: 10.1002/nbm.3831 |
NMR in Biomedicine 31/10 | 2019-03-18 |
| 2018 |
Jessica S. Lorenz, Jörg Schnauß, Martin Glaser, Martin Sajfutdinow, Carsten Schuldt, Josef A. Käs, David M. Smith Synthetic Transient Crosslinks Program the Mechanics of Soft, Biopolymer-Based Materials published pages: 1706092, ISSN: 0935-9648, DOI: 10.1002/adma.201706092 |
Advanced Materials 30/13 | 2019-03-18 |
| 2017 |
Linda Oswald, Steffen Grosser, David M Smith, Josef A Käs Jamming transitions in cancer published pages: 483001, ISSN: 0022-3727, DOI: 10.1088/1361-6463/aa8e83 |
Journal of Physics D: Applied Physics 50/48 | 2019-03-18 |
| 2018 |
Tom Golde, Constantin Huster, Martin Glaser, Tina Händler, Harald Herrmann, Josef A. Käs, Jörg Schnauß Glassy dynamics in composite biopolymer networks published pages: 7970-7978, ISSN: 1744-683X, DOI: 10.1039/c8sm01061g |
Soft Matter 14/39 | 2019-03-18 |
| 2017 |
Dan Strehle, Paul Mollenkopf, Martin Glaser, Tom Golde, Carsten Schuldt, Josef A. Käs, Jörg Schnauß Single Actin Bundle Rheology published pages: 1804, ISSN: 1420-3049, DOI: 10.3390/molecules22101804 |
Molecules 22/10 | 2019-03-18 |
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