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STEM-AGING SIGNED

Tissue regeneration and aging: the decisive quiescent stem-cell state

Total Cost €

EC-Contrib. €

Partnership

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STEM-AGING project word cloud

Explore the words cloud of the STEM-AGING project. It provides you a very rough idea of what is the project "STEM-AGING" about.

asymmetric waste fate turnover regeneration impairs divided rhythms homeostasis heterogeneity malfunction biology preferred regenerating 2016 tissues reporter 2014 unifying tracing ablation mice substitution molecular stemness stem underlie regulation experimental regenerative drive aged nature muscle variables though decline contributions maintenance converge basis active lies protein switch mechanisms cell cma senescence isolating autophagy hypothesis fundamental cells segregation connect age skeletal senescent quiescent follows quiescence completion chaperone circadian tissue mediated aging proteotoxic proteostasis regulators organs sensitive instructor poorly basic

Project "STEM-AGING" data sheet

The following table provides information about the project.

Coordinator	UNIVERSIDAD POMPEU FABRA Organization address address: PLACA DE LA MERCE, 10-12 city: BARCELONA postcode: 8002 website: www.upf.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	2˙499˙949 €
EC max contribution	2˙499˙949 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2016-ADG
Funding Scheme	ERC-ADG
Starting year	2017
Duration (year-month-day)	from 2017-11-01 to 2022-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSIDAD POMPEU FABRA UNIVERSIDAD POMPEU FABRA Organization address address: PLACA DE LA MERCE, 10-12 city: BARCELONA postcode: 8002 website: www.upf.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	coordinator	1˙251˙824.00
2	CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.) CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.) Organization address address: CALLE MELCHOR FERNANDEZ ALMAGRO 3 city: MADRID postcode: 28029 website: www.cnic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	1˙248˙125.00

Map

Project objective

The basic mechanisms of stem cell malfunction during aging are poorly understood even though they underlie the regenerative decline of most organs and tissues as we age. Based on our recent contributions (Nature 2014, Nature 2016), the fields of tissue regeneration and aging converge on the key role of the quiescent state, the preferred state of stem cells in low turnover tissues such as skeletal muscle. Our unifying hypothesis is that stem-cell quiescence maintenance, which requires active proteostasis (protein homeostasis), lies at the basis of stemness, and that its substitution by a senescence state in aging impairs regeneration. How these variables connect to drive stem cell aging is not known. Crucial experimental systems in this proposal are sensitive reporter mice for proteostasis, senescence and quiescence/fate in aging muscle stem cells. The project is divided as follows: Objective 1. Proteostasis and stem cell quiescence maintenance: tracing proteostasis in quiescent stem cells from autophagy and chaperone-mediated autophagy (CMA) reporter mice during aging / impact of autophagy/CMA loss on quiescence and regeneration / molecular regulators of proteostasis. Objective 2. Proteostasis and quiescent stem cell heterogeneity and fate: asymmetric segregation of proteotoxic waste as an instructor of stem cell heterogeneity and regenerative fate. Objective 3. The quiescence-to-senescence-switch in aging muscle stem cells: tracing and isolating senescent stem cells in senescence-cell reporter mice during aging / impact of senescent cell ablation on regenerating aged muscle. Objective 4. Circadian regulation in the quiescent stem-cell state: impact of aging on circadian rhythms and consequences for quiescence maintenance and regeneration. We expect that completion of these objectives will provide new fundamental knowledge on stem-cell biology, regeneration and aging.

Publications

List of publications.
year	authors and title	journal	last update
2017	Guiomar Solanas, Francisca Oliveira Peixoto, Eusebio Perdiguero, MercÃ¨ JardÃ, Vanessa Ruiz-Bonilla, Debayan Datta, Aikaterini Symeonidi, AndrÃ©s Castellanos, Patrick-Simon Welz, Juan MartÃn Caballero, Paolo Sassone-Corsi, Pura MuÃ±oz-CÃ¡noves, Salvador Aznar Benitah Aged Stem Cells Reprogram Their Daily Rhythmic Functions to Adapt to Stress published pages: 678-692.e20, ISSN: 0092-8674, DOI: 10.1016/j.cell.2017.07.035	Cell 170/4	2019-08-06

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The information about "STEM-AGING" are provided by the European Opendata Portal: CORDIS opendata.