Opendata, web and dolomites

ThermalMR SIGNED

Thermal Magnetic Resonance: A New Instrument to Define the Role of Temperature in Biological Systems and Disease for Diagnosis and Therapy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ThermalMR project word cloud

Explore the words cloud of the ThermalMR project. It provides you a very rough idea of what is the project "ThermalMR" about.

nanocarriers    understand    diverse    adapt    implications    responsive    diagnosis    magnetic    manipulations    contrasts    focal    intense    critical    transfer    exquisitely    biological    model    rf    explored    relevance    medicine    therapeutic    demonstrated    thermalmr    device    mainstay    drug    life    capacity    physical    frequencies    heat    performed    vivo    radio    thermal    subsequent    modulation    thermo    dosage    uhf    models    fidelity    temperature    resolution    pathological    imperative    strategies    release    signatures    loaded    dosimetry    regions    followed    entirely    intervention    tissues    ultrahigh    invasive    dimension    inherent    profiling    safety    arrays    lacks    meet    physics    clinical    generate    subjects    thermometry    pioneering    resonance    transmitter    conventional    healthy    mr    eradicate    density    19f    fluorinated    feasibility    expression    instrument    biology    link    probes    imaging    modulate    quantifiable    tissue    revolutionary    employs    barriers    precise    poorly    efficacy    simulations    explore    phenotyping    manipulation    opens    animal    electrical    applicability    molecular    tool    gene   

Project "ThermalMR" data sheet

The following table provides information about the project.

Coordinator
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC) 

Organization address
address: ROBERT ROSSLE STRASSE 10
city: BERLIN
postcode: 13125
website: www.mdc-berlin.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.mdc-berlin.de/news/2017/20170322-millionenfoerderung-vom-europaeischen-forschungsrat-fuer-zwei-mdc-forscher
 Total cost 2˙043˙804 €
 EC max contribution 2˙043˙804 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC) DE (BERLIN) coordinator 2˙043˙804.00

Map

 Project objective

Temperature is a physical parameter with diverse biological implications and crucial clinical relevance. With an ever increasing interest in thermal applications, non-invasive in vivo methods to modulate temperature and characterize subsequent effects are imperative. Magnetic resonance (MR) is a mainstay of diagnosis but lacks inherent means for focal thermal modulation. Ultrahigh field (UHF) MR employs higher radio frequencies (RF) than conventional MR and has unique potential to provide focal temperature manipulation and high resolution imaging (ThermalMR). Our simulations show that we can adapt an UHF- MR device to generate heat in highly focused regions of tissue by using high-density RF transmitter arrays. This new instrument will provide a revolutionary method for precise in vivo temperature manipulations. To establish high-fidelity thermal dosimetry, we will investigate pioneering strategies that exploit electrical and heat transfer tissue properties. For thermal dosage control, novel methods of MR thermometry will be developed. The capacity of ThermalMR for thermal intervention will be demonstrated in model systems. Its efficacy for drug release will be explored using new thermo-responsive nanocarriers loaded with fluorinated probes, exquisitely quantifiable with 19F MR. The applicability and safety of ThermalMR will be demonstrated in animal models followed by a feasibility study in healthy subjects. To link thermal responses of MR contrasts with molecular signatures, gene expression profiling will be performed. The aim is to understand the thermal properties of healthy and pathological tissues and explore the use of temperature modulation as a therapeutic tool. ThermalMR will eradicate the main barriers to the study and use of temperature - a critical dimension of life that is of intense clinical interest, but so far very poorly understood. This approach opens an entirely new research field of thermal phenotyping: where physics, biology and medicine meet.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "THERMALMR" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "THERMALMR" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

HyperBio (2019)

Vis-NIR Hyperspectral imaging for biomaterial quality control

Read More  

BALANCE (2019)

Mapping Dispersion Spectroscopically in Large Gas-Phase Molecular Ions

Read More  

OSIRIS (2020)

Automatic measurement of speech understanding using EEG

Read More