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ThermalMR SIGNED

Thermal Magnetic Resonance: A New Instrument to Define the Role of Temperature in Biological Systems and Disease for Diagnosis and Therapy

Total Cost €

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EC-Contrib. €

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Partnership

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 ThermalMR project word cloud

Explore the words cloud of the ThermalMR project. It provides you a very rough idea of what is the project "ThermalMR" about.

dimension    manipulations    efficacy    models    release    thermalmr    model    rf    responsive    regions    molecular    explore    tissues    resonance    diagnosis    strategies    modulate    intense    life    heat    eradicate    critical    inherent    signatures    thermo    demonstrated    mr    tool    imperative    vivo    manipulation    dosimetry    precise    feasibility    frequencies    diverse    density    lacks    employs    clinical    biological    explored    phenotyping    nanocarriers    radio    healthy    link    electrical    mainstay    thermal    invasive    pioneering    meet    tissue    understand    expression    opens    contrasts    adapt    ultrahigh    intervention    subsequent    focal    therapeutic    physics    19f    exquisitely    revolutionary    arrays    poorly    subjects    barriers    fidelity    transfer    quantifiable    transmitter    profiling    device    imaging    fluorinated    drug    temperature    performed    entirely    magnetic    capacity    physical    gene    implications    followed    resolution    thermometry    safety    probes    medicine    applicability    conventional    simulations    generate    dosage    uhf    pathological    biology    relevance    animal    loaded    instrument    modulation   

Project "ThermalMR" data sheet

The following table provides information about the project.

Coordinator
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC) 

Organization address
address: ROBERT ROSSLE STRASSE 10
city: BERLIN
postcode: 13125
website: www.mdc-berlin.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.mdc-berlin.de/news/2017/20170322-millionenfoerderung-vom-europaeischen-forschungsrat-fuer-zwei-mdc-forscher
 Total cost 2˙043˙804 €
 EC max contribution 2˙043˙804 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC) DE (BERLIN) coordinator 2˙043˙804.00

Map

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 Project objective

Temperature is a physical parameter with diverse biological implications and crucial clinical relevance. With an ever increasing interest in thermal applications, non-invasive in vivo methods to modulate temperature and characterize subsequent effects are imperative. Magnetic resonance (MR) is a mainstay of diagnosis but lacks inherent means for focal thermal modulation. Ultrahigh field (UHF) MR employs higher radio frequencies (RF) than conventional MR and has unique potential to provide focal temperature manipulation and high resolution imaging (ThermalMR). Our simulations show that we can adapt an UHF- MR device to generate heat in highly focused regions of tissue by using high-density RF transmitter arrays. This new instrument will provide a revolutionary method for precise in vivo temperature manipulations. To establish high-fidelity thermal dosimetry, we will investigate pioneering strategies that exploit electrical and heat transfer tissue properties. For thermal dosage control, novel methods of MR thermometry will be developed. The capacity of ThermalMR for thermal intervention will be demonstrated in model systems. Its efficacy for drug release will be explored using new thermo-responsive nanocarriers loaded with fluorinated probes, exquisitely quantifiable with 19F MR. The applicability and safety of ThermalMR will be demonstrated in animal models followed by a feasibility study in healthy subjects. To link thermal responses of MR contrasts with molecular signatures, gene expression profiling will be performed. The aim is to understand the thermal properties of healthy and pathological tissues and explore the use of temperature modulation as a therapeutic tool. ThermalMR will eradicate the main barriers to the study and use of temperature - a critical dimension of life that is of intense clinical interest, but so far very poorly understood. This approach opens an entirely new research field of thermal phenotyping: where physics, biology and medicine meet.

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The information about "THERMALMR" are provided by the European Opendata Portal: CORDIS opendata.

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