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PAINTBOX SIGNED

Pancreatic islet dysfunction and type 2 diabetes – beyond the genome

Total Cost €

EC-Contrib. €

Partnership

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PAINTBOX project word cloud

Explore the words cloud of the PAINTBOX project. It provides you a very rough idea of what is the project "PAINTBOX" about.

sequencing t2d exploits variants expertise strategies clinical powerful islet mathematical disease metabolic gene whereas association fulfill persist medicine innovative pathogenetic technologies epigenomic interdisciplinary prevent genomic previously models patient genome opens paintbox despite techniques cure tools combine capitalizes surprisingly translation editing environmental pioneered prevalence discoveries diabetes worldwide cohorts multidisciplinary cohort world genetic efforts proportion groundbreaking urgent acute annotation treatment me heritability prospective pancreatic islets prevention human mathematics small disorders epi prediction uncover ways primary epigenetic generate mechanisms tissue play twenty criteria epigenetics permit causing horizons

Project "PAINTBOX" data sheet

The following table provides information about the project.

Coordinator	LUNDS UNIVERSITET Organization address address: Paradisgatan 5c city: LUND postcode: 22100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Sweden [SE]
Total cost	1˙969˙445 €
EC max contribution	1˙969˙445 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2016-COG
Funding Scheme	ERC-COG
Starting year	2017
Duration (year-month-day)	from 2017-10-01 to 2022-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	LUNDS UNIVERSITET LUNDS UNIVERSITET Organization address address: Paradisgatan 5c city: LUND postcode: 22100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (LUND)	coordinator	1˙969˙445.00

Map

Project objective

The prevalence of type 2 diabetes (T2D) is rapidly increasing worldwide and despite great efforts to prevent and cure the disease, the increase persist. There is an urgent need to develop innovative and effective prevention and treatment strategies for T2D.

Recent genome-wide association studies were expected to uncover disease-causing mechanisms in common metabolic disorders. Surprisingly, the identified genetic variants only explain a small proportion of the estimated heritability of T2D. Novel studies, going beyond the genome, are therefore needed to identify key mechanisms causing T2D. These studies should focus on pancreatic islets, the tissue of primary pathogenetic importance for diabetes. Also, mechanisms that allow environmental factors to come into play are likely to be important. Epigenetics fulfill such criteria, and our previous work has pioneered epigenetic discoveries in T2D.

PAINTBOX is a multidisciplinary research program through which I will combine advanced sequencing technologies and novel epigenetic methods with mathematical models and clinical medicine to develop new prediction and treatment strategies for T2D. Innovative techniques and access to some of the world´s best patient cohorts permit me to address the role of epigenetics in development of T2D in new ways. The annotation of these discoveries will be done using genome-wide epigenomic and targeted gene-editing tools together with mathematics, whereas the translation of those findings will be achieved using powerful prospective cohorts for T2D and clinical studies.

PAINTBOX capitalizes on the largest existing human islet cohort and large prospective cohorts, and expertise that I have built-up over the past twenty years, but also exploits novel epi-genomic and gene-editing technologies that have not previously been used for T2D. I expect this novel interdisciplinary project to generate groundbreaking results that opens up new horizons for prediction, prevention and treatment of T2D.

Publications

List of publications.
year	authors and title	journal	last update
2018	Mahboubeh Daneshpajooh, Lena Eliasson, Karl Bacos, Charlotte Ling MC1568 improves insulin secretion in islets from type 2 diabetes patients and rescues Î²-cell dysfunction caused by Hdac7 upregulation published pages: 1231-1235, ISSN: 0940-5429, DOI: 10.1007/s00592-018-1201-4	Acta Diabetologica 55/12	2019-07-18
2019	Charlotte Ling, Tina RÃ¶nn Epigenetics in Human Obesity and Type 2 Diabetes published pages: 1028-1044, ISSN: 1550-4131, DOI: 10.1016/j.cmet.2019.03.009	Cell Metabolism 29/5	2019-07-18

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