Explore the words cloud of the PurinesDX project. It provides you a very rough idea of what is the project "PurinesDX" about.
The following table provides information about the project.
Coordinator |
ROYAL COLLEGE OF SURGEONS IN IRELAND
Organization address contact info |
Coordinator Country | Ireland [IE] |
Project website | http://www.purinesdx.eu |
Total cost | 3˙487˙463 € |
EC max contribution | 3˙487˙463 € (100%) |
Programme |
1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers) |
Code Call | H2020-MSCA-ITN-2017 |
Funding Scheme | MSCA-ITN-ETN |
Starting year | 2017 |
Duration (year-month-day) | from 2017-09-01 to 2021-08-31 |
Take a look of project's partnership.
Brain disorders affect ~179 million people and their families in Europe alone, with an annual cost to the taxpayer estimated at €800 billion- a greater economic burden than cardiovascular disease and cancer combined. Despite diverse etiology, overlap in clinical symptoms and comorbidities between brain disorders suggests shared patho-mechanisms. In particular, hyperexcitible states driven by glial activation and neuroinflammation appear near ubiquitous. Targeting these mechanisms offers the potential to ameliorate symptoms and reverse disease progression across a broad span of brain disorders. Functioning as a gatekeeper to neuroinflammation and mechanistic link between neuronal hyperexcitability and glial activation, the ATP-gated, ionotropic purinergic P2X7 receptor (P2X7R) offers the most promising target for pharmacological intervention in the neuroinflammation-hyperexcitability pathway, to date. With breakthroughs in understanding P2X7R function, highly promising effects demonstrated for antagonists in models of brain disease and vast investment in P2X7R-related drug development programmes, now is the perfect time to pool resources. PurinesDX brings together global leaders in translational research in purinergic signalling, Europe’s leading clinical specialists in a broad range of brain diseases, and industrial partners specializing in drug and biomarker development. Sharing unique genetic tools, newly developed diagnostic devices and novel, selective and brain-stable P2X7R antagonists, the synergism facilitated within PurinesDX will extend to the training of an urgently needed new generation of highly skilled, innovative, creative and entrepreneurial scientists. Alongside the provision of this interdisciplinary, international and intersectoral environment, an original and high level training in state-of-the-art neuroscience will be provided, nurturing a cohort of highly competitive researchers with potential to drive a new era of neuroscience research.
Network-wide training events M18 | Documents, reports | 2020-02-12 17:31:28 |
Network-wide training events M24 | Documents, reports | 2020-02-12 17:31:30 |
Risk protocol M18 | Documents, reports | 2020-02-12 17:31:31 |
Dissemination diary and report of dissemination events M24 | Other | 2020-02-12 17:31:32 |
Report on communication and public engagement activities M24 | Documents, reports | 2020-02-12 17:31:29 |
Report on gender equality in PurinesDX M24 | Documents, reports | 2020-02-12 17:31:31 |
Launch of website, Twitter, Facebook, LinkedIn, GooglePlus | Documents, reports | 2019-07-08 11:33:29 |
Network-wide training events M12 | Documents, reports | 2019-07-08 11:33:28 |
Dissemination diary and report of dissemination events M12 | Other | 2019-07-08 11:33:28 |
Report on communication and public engagement activities M12 | Documents, reports | 2019-07-08 11:33:28 |
Recruitment completion and ESR contracts | Other | 2019-07-08 11:33:28 |
Report on communication and public engagement activities M6 | Documents, reports | 2019-07-08 11:33:28 |
Network-wide training events M8 | Documents, reports | 2019-07-08 11:33:28 |
Supervisory Board of the network | Other | 2019-07-08 11:33:29 |
Report on gender equality in PurinesDX M12 | Documents, reports | 2019-07-08 11:33:29 |
Take a look to the deliverables list in detail: detailed list of PurinesDX deliverables.
year | authors and title | journal | last update |
---|---|---|---|
2018 |
Gabriele Stephan, Lumei Huang, Yong Tang, Sandra Vilotti, Elsa Fabbretti, Ye Yu, Wolfgang Nörenberg, Heike Franke, Flóra Gölöncsér, Beáta Sperlágh, Anke Dopychai, Ralf Hausmann, Günther Schmalzing, Patrizia Rubini, Peter Illes The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03728-5 |
Nature Communications 9/1 | 2019-11-07 |
2018 |
Edward H. Beamer, Jeronimo Jurado-Arjona, Eva M. Jimenez-Mateos, James Morgan, Cristina R. Reschke, Aidan Kenny, Gioacchino de Leo, Luis A. Olivos-Oré, Marina Arribas-Blázquez, Stephen F. Madden, Jesús Merchán-Rubira, Norman Delanty, Michael A. Farrell, Donncha F. O’Brien, Jesus Avila, Miguel Diaz-Hernandez, M. Teresa Miras-Portugal, Antonio R. Artalejo, Felix Hernandez, David C. Henshall, T MicroRNA-22 Controls Aberrant Neurogenesis and Changes in Neuronal Morphology After Status Epilepticus published pages: , ISSN: 1662-5099, DOI: 10.3389/fnmol.2018.00442 |
Frontiers in Molecular Neuroscience 11 | 2019-11-07 |
2019 |
Carlos MartÃnez-Frailes, Caterina Di Lauro, Carolina Bianchi, Laura de Diego-GarcÃa, Ãlvaro Sebastián-Serrano, Lisardo Boscá, Miguel DÃaz-Hernández Amyloid Peptide Induced Neuroinflammation Increases the P2X7 Receptor Expression in Microglial Cells, Impacting on Its Functionality published pages: , ISSN: 1662-5102, DOI: 10.3389/fncel.2019.00143 |
Frontiers in Cellular Neuroscience 13 | 2019-08-05 |
2018 |
Tobias Engel, Raquel Gómez-Sintes, Mariana Alves, Eva M. Jimenez-Mateos, Marta Fernández-Nogales, Amaya Sanz-Rodriguez, James Morgan, Edward Beamer, Alberto RodrÃguez-Matellán, Mark Dunleavy, Takanori Sano, Jesus Avila, Miguel Medina, Felix Hernandez, José J. Lucas, David C. Henshall Bi-directional genetic modulation of GSK-3β exacerbates hippocampal neuropathology in experimental status epilepticus published pages: , ISSN: 2041-4889, DOI: 10.1038/s41419-018-0963-5 |
Cell Death & Disease 9/10 | 2019-07-08 |
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The information about "PURINESDX" are provided by the European Opendata Portal: CORDIS opendata.