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DeLIVER SIGNED

Super-resolution optical microscopy of nanosized pore dynamics in endothelial cells

Total Cost €

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EC-Contrib. €

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Partnership

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DeLIVER project word cloud

Explore the words cloud of the DeLIVER project. It provides you a very rough idea of what is the project "DeLIVER" about.

little arise ec instil maximising mobile skills manipulation tissues active navigate clearance innovative economic nanoscopes prospects enterprises confidently biomedical extremely resolution pharmaceuticals transfer generation reconstruction scientific image discoveries first creative pores clinical blood biomedicine benefits career excellent cells area isolated artifacts deliver mind physics private reveal barrier super liver themselves analytical optical time name eyes metabolites physiology nanosized function academic newcomers enhanced international cross interface biomedically pollinated train combined sciences dead familiarize physical physiological human kidneys structures esrs endothelial vital slow specialised imaging training dynamics micro complementary organs brain trained speed intersectoral entrepreneurial tools nanoscopy fixed newly

Project "DeLIVER" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAET BIELEFELD Organization address address: UNIVERSITAETSSTRASSE 25 city: BIELEFELD postcode: 33615 website: www.uni-bielefeld.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Total cost	3˙728˙513 €
EC max contribution	3˙728˙513 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2017
Funding Scheme	MSCA-ITN-ETN
Starting year	2018
Duration (year-month-day)	from 2018-01-01 to 2021-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAET BIELEFELD UNIVERSITAET BIELEFELD Organization address address: UNIVERSITAETSSTRASSE 25 city: BIELEFELD postcode: 33615 website: www.uni-bielefeld.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BIELEFELD)	coordinator	747˙649.00
2	UNIVERSITETET I TROMSOE - NORGES ARKTISKE UNIVERSITET UNIVERSITETET I TROMSOE - NORGES ARKTISKE UNIVERSITET Organization address address: HANSINE HANSENS VEG 14 city: TROMSO postcode: 9019 website: http://uit.no/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (TROMSO)	participant	1˙145˙100.00
3	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Organization address address: WELLINGTON SQUARE UNIVERSITY OFFICES city: OXFORD postcode: OX1 2JD website: www.ox.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (OXFORD)	participant	273˙287.00
4	THE UNIVERSITY OF BIRMINGHAM THE UNIVERSITY OF BIRMINGHAM Organization address address: Edgbaston city: BIRMINGHAM postcode: B15 2TT website: www.bham.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BIRMINGHAM)	participant	273˙287.00
5	GOETEBORGS UNIVERSITET GOETEBORGS UNIVERSITET Organization address address: VASAPARKEN city: GOETEBORG postcode: 405 30 website: www.gu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (GOETEBORG)	participant	263˙659.00
6	CHERRY BIOTECH CHERRY BIOTECH Organization address address: 6 RUE GURVAND city: RENNES postcode: 35000 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (RENNES)	participant	262˙875.00
7	ELVESYS ELVESYS Organization address address: 1-3 BIS RUE ROBERT ET SONIA DELAUNAY city: PARIS postcode: 75011 website: www.elvesys.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	262˙875.00
8	VRIJE UNIVERSITEIT BRUSSEL VRIJE UNIVERSITEIT BRUSSEL Organization address address: PLEINLAAN 2 city: BRUSSEL postcode: 1050 website: www.vub.ac.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUSSEL)	participant	250˙560.00
9	LAVISION BIOTEC GMBH LAVISION BIOTEC GMBH Organization address address: ASTASTRASSE 14 city: BIELEFELD postcode: 33617 website: www.lavisionbiotec.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BIELEFELD)	participant	249˙216.00
10	ANZAC Health & Medical Research Foundation ANZAC Health & Medical Research Foundation Organization address address: GATE 3, HOSPITAL ROAD, city: CONCORD NSW postcode: 2139 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AU (CONCORD NSW)	partner	0.00
11	BAYER AKTIENGESELLSCHAFT BAYER AKTIENGESELLSCHAFT Organization address address: KAISER-WILHEM-ALLEE 1 city: Leverkusen postcode: 51373 website: http://pharma.bayer.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Leverkusen)	partner	0.00
12	Norinnova Technology Transfer AS Norinnova Technology Transfer AS Organization address address: Sykehusvegen 23 city: Tromsø postcode: 9294 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (Tromsø)	partner	0.00
13	THE UNIVERSITY OF HONG KONG THE UNIVERSITY OF HONG KONG Organization address address: Pokfulam Road city: Pokfulam postcode: n.a. website: www.hku.hk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	HK (Pokfulam)	partner	0.00
14	United States Department of Health and Human Services United States Department of Health and Human Services Organization address address: Independence Avenue S. W. 200 city: Washington D.C. postcode: 20201 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (Washington D.C.)	partner	0.00

Map

Project objective

DeLIVER will train a new generation of ESRs in the development and application of newly developed high speed and high resolution imaging tools in biomedical research. ESRs will be cross-pollinated with concepts and skills in physics and biomedicine, in particular in super-resolution optical imaging (a.k.a. optical nanoscopy), analytical image reconstruction, and optical micro-manipulation methods. These skills are applied to reveal for the first time the function and dynamics of nanosized pores in endothelial cells (EC) that present the main barrier between the blood and vital organs for human physiology, such as the liver, brain, kidneys, and the eyes. Very little is known about the extremely important physiological function of these unique structures and their role in the transfer and/or clearance of metabolites and pharmaceuticals to vital organs. The current generation of optical nanoscopes, however, is rather slow and can only be applied to isolated, typically fixed (i.e. dead) cells rather than biomedically relevant tissues. Also, newcomers to the field need to familiarize themselves with a whole new set of potential problems that might arise in the use of optical nanoscopy, such as image reconstruction-related artifacts to name just one example.This is an area of research where European enterprises are very active. Excellent training in new scientific and complementary skills, combined with international and intersectoral work experience, will instil an innovative, creative and entrepreneurial mind-set in DeLIVER's ESRs, maximising economic benefits based on scientific discoveries. These specialised, highly trained, and mobile ESRs will have greatly enhanced career prospects. The training in novel physical methods with highly relevant experience in the biomedical sciences will allow them to confidently navigate at the interface of academic, clinical and private sector research.

Publications

List of publications.
year	authors and title	journal	last update
2019	Adrien Descloux, Marcel MÃ¼ller, Vytautas Navikas, Andreas Markwirth, Robin van den Eynde, Tomas Lukes, Wolfgang HÃ¼bner, Theo Lasser, Aleksandra Radenovic, Peter Dedecker, Thomas Huser High-speed multiplane structured illumination microscopy of living cells using an image-splitting prism published pages: 143-148, ISSN: 2192-8614, DOI: 10.1515/nanoph-2019-0346	Nanophotonics 9/1	2020-03-05
2019	Robin Van den Eynde, Alice Sandmeyer, Wim Vandenberg, Sam DuwÃ©, Wolfgang HÃ¼bner, Thomas Huser, Peter Dedecker, Marcel MÃ¼ller Quantitative comparison of camera technologies for cost-effective super-resolution optical fluctuation imaging (SOFI) published pages: 44001, ISSN: 2515-7647, DOI: 10.1088/2515-7647/ab36ae	Journal of Physics: Photonics 1/4	2020-03-05
2019	Andreas Markwirth, Mario Lachetta, Viola MÃ¶nkemÃ¶ller, Rainer Heintzmann, Wolfgang HÃ¼bner, Thomas Huser, Marcel MÃ¼ller Video-rate multi-color structured illumination microscopy with simultaneous real-time reconstruction published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-12165-x	Nature Communications 10/1	2020-03-05
2020	Cihang Kong, Christian Pilger, Henning Hachmeister, Xiaoming Wei, Tom H. Cheung, Cora S. W. Lai, Nikki P. Lee, Kevin. K. Tsia, Kenneth K. Y. Wong, Thomas Huser High-contrast, fast chemical imaging by coherent Raman scattering using a self-synchronized two-colour fibre laser published pages: , ISSN: 2047-7538, DOI: 10.1038/s41377-020-0259-2	Light: Science & Applications 9/1	2020-03-05
2020	NIKHIL JAYAKUMAR, Azeem Ahmad, Dalip Mehta, Balpreet Ahluwalia Sampling moirÃ© method: a tool for sensing quadratic phase distortion and its correction for accurate quantitative phase microscopy published pages: , ISSN: 1094-4087, DOI: 10.1364/oe.383461	Optics Express	2020-03-05
2018	Cristina I. Ã˜ie, Viola MÃ¶nkemÃ¶ller, Wolfgang HÃ¼bner, Mark SchÃ¼ttpelz, Hong Mao, Balpreet S. Ahluwalia, Thomas R. Huser, Peter McCourt New ways of looking at very small holes â€“ using optical nanoscopy to visualize liver sinusoidal endothelial cell fenestrations published pages: 575-596, ISSN: 2192-8614, DOI: 10.1515/nanoph-2017-0055	Nanophotonics 7/3	2020-02-21
2018	Viola MÃ¶nkemÃ¶ller, Hong Mao, Wolfgang HÃ¼bner, Gianina Dumitriu, Peter Heimann, Gahl Levy, Thomas Huser, Barbara Kaltschmidt, Christian Kaltschmidt, Cristina I. Ã˜ie Primary rat LSECs preserve their characteristic phenotype after cryopreservation published pages: 10, ISSN: 2045-2322, DOI: 10.1038/s41598-018-32103-z	Scientific Reports 8/1	2020-02-21
2019	Lothar Schermelleh, Alexia Ferrand, Thomas Huser, Christian Eggeling, Markus Sauer, Oliver Biehlmaier, Gregor P. C. Drummen Super-resolution microscopy demystified published pages: 72-84, ISSN: 1465-7392, DOI: 10.1038/s41556-018-0251-8	Nature Cell Biology 21/1	2020-02-21

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