MNEMONIC SIGNED
Magnetic Enzyme Metal Organic Framework Composites
Total Cost €
0EC-Contrib. €
0Partnership
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0MNEMONIC project word cloud
Explore the words cloud of the MNEMONIC project. It provides you a very rough idea of what is the project "MNEMONIC" about.
Project "MNEMONIC" data sheet
The following table provides information about the project.
| Coordinator |
TECHNISCHE UNIVERSITAET GRAZ
Organization address contact info |
| Coordinator Country | Austria [AT] |
| Total cost | 166˙156 € |
| EC max contribution | 166˙156 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2016 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-11-01 to 2019-10-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | TECHNISCHE UNIVERSITAET GRAZ | AT (GRAZ) | coordinator | 166˙156.00 |
Map
Project objective
The aim of this interdisciplinary project is to develop composites consisting of metal-organic frameworks (MOFs), magnetic nanoparticles (MNPs), and enzymes. The MOF coating protects the biomacromolecule from inhospitable conditions, and provides a permeable and selective molecular gate for the diffusion of substrates and products, thanks to its intrinsic and tunable porosity. External magnetic forces acts on the MNPs to allow for precise positioning of this ternary system. These highly efficient, long-lasting, robust, and dynamically positionable crystalline biocatalysts will be synthesized using the recently discovered biomimetic mineralization process, in which MOF precursors, metal ions, and organic ligands nucleates on the biomacromolecule without the need of stabilizing polymers or organic solvents, in aqueous solution at room temperature. This innovative technique has been proven successful for a wide range of protein and enzymes, and is currently the best performing procedure available for this class of porous material in terms of efficiency of enzyme encapsulation, absence of leaching, and reactions conditions and time. Key aspects of the project will be: the production of enzymes suitable for a multistep process; the synthesis and characterization of the composites; finally their integration into fluidic devices. The effects of process variables on particle size and morphology, enzyme loading and activity, MOF robustness, magnetic properties, and recyclability of the composite will be investigated with a multifaceted analytic approach. The long-term impact of this project includes technological benefits for industrial biotechnology, owing to the superior resistance of MOF-coated enzymes towards organic solvents, heat, and inhibitors, along with the presence of MNPs that permits the easy recovery of the MagEnzMOFs and their integration into fluidic reactors, to provide continuous production with high automation.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Ricco, R., Amenitsch, H., Falcaro, P. Magnetically responsive horseradish peroxidase@ZIF-8 for biocatalysts published pages: , ISSN: 1359-7345, DOI: |
Chemical Communications | 2020-02-05 |
| 2019 |
Arpita Poddar, José J. Conesa, Kang Liang, Sudip Dhakal, Philipp Reineck, Gary Bryant, Eva Pereiro, Raffaele Ricco, Heinz Amenitsch, Christian Doonan, Xavier Mulet, Cara M. Doherty, Paolo Falcaro, Ravi Shukla Encapsulation, Visualization and Expression of Genes with Biomimetically Mineralized Zeolitic Imidazolate Frameworkâ€8 (ZIFâ€8) published pages: 1902268, ISSN: 1613-6810, DOI: 10.1002/smll.201902268 |
Small 15/36 | 2020-02-05 |
| 2018 |
Alessandra Pinna, Raffaele Ricco\', Rossana Migheli, Gaia Rocchitta, Pier Andrea Serra, Paolo Falcaro, Luca Malfatti, Plinio Innocenzi A MOF-based carrier for in situ dopamine delivery published pages: 25664-25672, ISSN: 2046-2069, DOI: 10.1039/c8ra04969f |
RSC Advances 8/45 | 2019-12-16 |
| 2019 |
F. Carraro, M. de J. Velasquez-Hernandez, E. Astria, W. Liang, L. Twight, C. Parise, Z. Huang, G. Meng, R. Ricco, X. Zou, L. Villanova, O. Kappe, C. Doonan, P. Falcaro Phase dependent encapsulation and release profile of ZIF-based biocomposites published pages: , ISSN: 2041-6539, DOI: |
Chemical Science | 2019-12-16 |
| 2019 |
Efwita Astria, Martin Thonhofer, Raffaele Ricco, Weibin Liang, Angela Chemelli, Andrew Tarzia, Karen Alt, Christoph E. Hagemeyer, Johannes Rattenberger, Hartmuth Schroettner, Tanja Wrodnigg, Heinz Amenitsch, David M. Huang, Christian J. Doonan, Paolo Falcaro Carbohydrates@MOFs published pages: 969-977, ISSN: 2051-6355, DOI: 10.1039/c8mh01611a |
Materials Horizons 6/5 | 2019-12-16 |
| 2018 |
Raffaele Riccò, Oliver Linder-Patton, Kenji Sumida, Mark J. Styles, Kang Liang, Heinz Amenitsch, Christian J. Doonan, Paolo Falcaro Conversion of Copper Carbonate into a Metal–Organic Framework published pages: 5630-5638, ISSN: 0897-4756, DOI: 10.1021/acs.chemmater.8b01891 |
Chemistry of Materials 30/16 | 2019-12-16 |
| 2018 |
R. Riccò, S. Nizzero, E. Penna, A. Meneghello, E. Cretaio, F. Enrichi Ultra-small dye-doped silica nanoparticles via modified sol-gel technique published pages: , ISSN: 1388-0764, DOI: 10.1007/s11051-018-4227-1 |
Journal of Nanoparticle Research 20/5 | 2019-12-16 |
| 2019 |
Miriam de J. Velásquez-Hernández, Raffaele Ricco, Francesco Carraro, F. Ted Limpoco, Mercedes Linares-Moreau, Erich Leitner, Helmar Wiltsche, Johannes Rattenberger, Hartmuth Schröttner, Philipp Frühwirt, Eduard M. Stadler, Georg Gescheidt, Heinz Amenitsch, Christian J. Doonan, Paolo Falcaro Degradation of ZIF-8 in phosphate buffered saline media published pages: 4538-4544, ISSN: 1466-8033, DOI: 10.1039/c9ce00757a |
CrystEngComm 21/31 | 2019-12-16 |
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