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AUTISMS SIGNED

Decomposing Heterogeneity in Autism Spectrum Disorders

Total Cost €

EC-Contrib. €

Partnership

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AUTISMS project word cloud

Explore the words cloud of the AUTISMS project. It provides you a very rough idea of what is the project "AUTISMS" about.

society multivariate strategies individual disorders deep public signal medicine health translational warranting size unsupervised techniques personalized manifests subgroups highlight issue intervention computational genomic idea characterizing broad prioritization big precision patient autism valuable asd kinds promise social neural phenotypic accelerate substantial levels discovering pronounced discovery engage etiological decomposing progress 2 reduce sex ideals measured treatment burden stratification goals subtypes differentiate distinctions families multiple examine heterogeneity biological monitoring hold lives variables data begin clinical population autisms language spectrum individuals circuits preferences

Project "AUTISMS" data sheet

The following table provides information about the project.

Coordinator	FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA Organization address address: VIA MOREGO 30 city: GENOVA postcode: 16163 website: www.iit.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Total cost	1˙499˙444 €
EC max contribution	1˙499˙444 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-STG
Funding Scheme	ERC-STG
Starting year	2018
Duration (year-month-day)	from 2018-01-01 to 2022-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA Organization address address: VIA MOREGO 30 city: GENOVA postcode: 16163 website: www.iit.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (GENOVA)	coordinator	1˙122˙969.00
2	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Organization address address: FRANKLIN STREET 1111, 12 FLOOR city: OAKLAND CA postcode: 94607 website: http://www.universityofcalifornia.edu/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (OAKLAND CA)	participant	281˙250.00
3	UNIVERSITY OF CYPRUS UNIVERSITY OF CYPRUS Organization address address: KALLIPOLEOS STREET 75 city: NICOSIA postcode: 1678 website: www.ucy.ac.cy contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CY (NICOSIA)	participant	95˙224.00

Map

Project objective

Autism spectrum disorders (ASD) affect 1-2% of the population and are a major public health issue. Heterogeneity between affected ASD individuals is substantial both at clinical and etiological levels, thus warranting the idea that we should begin characterizing the ASD population as multiple kinds of ‘autisms’. Without an advanced understanding of how heterogeneity manifests in ASD, it is likely that we will not make pronounced progress towards translational research goals that can have real impact on patient’s lives. This research program is focused on decomposing heterogeneity in ASD at multiple levels of analysis. Using multiple ‘big data’ resources that are both ‘broad’ (large sample size) and ‘deep’ (multiple levels of analysis measured within each individual), I will examine how known variables such as sex, early language development, early social preferences, and early intervention treatment response may be important stratification variables that differentiate ASD subgroups at phenotypic, neural systems/circuits, and genomic levels of analysis. In addition to examining known stratification variables, this research program will engage in data-driven discovery via application of advanced unsupervised computational techniques that can highlight novel multivariate distinctions in the data that signal important ASD subgroups. These data-driven approaches may hold promise for discovering novel ASD subgroups at biological and phenotypic levels of analysis that may be valuable for prioritization in future work developing personalized assessment, monitoring, and treatment strategies for subsets of the ASD population. By enhancing the precision of our understanding about multiple subtypes of ASD this work will help accelerate progress towards the ideals of personalized medicine and help to reduce the burden of ASD on individuals, families, and society.

Publications

List of publications.
year	authors and title	journal	last update
2019	Saashi A. Bedford, Min Tae M. Park, Gabriel A. Devenyi, Stephanie Tullo, Jurgen Germann, Raihaan Patel, Evdokia Anagnostou, Simon Baron-Cohen, Edward T. Bullmore, Lindsay R. Chura, Michael C. Craig, Christine Ecker, Dorothea L. Floris, Rosemary J. Holt, Rhoshel Lenroot, Jason P. Lerch, Michael V. Lombardo, Declan G. M. Murphy, Armin Raznahan, Amber N. V. Ruigrok, Elizabeth Smith, Michael D. Spence Large-scale analyses of the relationship between sex, age and intelligence quotient heterogeneity and cortical morphometry in autism spectrum disorder published pages: , ISSN: 1359-4184, DOI: 10.1038/s41380-019-0420-6	Molecular Psychiatry	2020-01-30
2019	Julian Tillmann, Antonia San JosÃ© CÃ¡ceres, Chris H. Chatham, Daisy Crawley, Rosemary Holt, Bethany Oakley, Tobias Banaschewski, Simon Baron-Cohen, Sven BÃ¶lte, Jan K. Buitelaar, Sarah Durston, Lindsay Ham, Eva Loth, Emily Simonoff, Will Spooren, Declan G. Murphy, Tony Charman Investigating the factors underlying adaptive functioning in autism in the EU-AIMS Longitudinal European Autism Project published pages: , ISSN: 1939-3792, DOI: 10.1002/aur.2081	Autism Research	2020-01-30
2019	Eric Courchesne, Tiziano Pramparo, Vahid H. Gazestani, Michael V. Lombardo, Karen Pierce, Nathan E. Lewis The ASD Living Biology: from cell proliferation to clinical phenotype published pages: 88-107, ISSN: 1359-4184, DOI: 10.1038/s41380-018-0056-y	Molecular Psychiatry 24/1	2020-01-30
2019	Marianne Oldehinkel, Maarten Mennes, Andre Marquand, Tony Charman, Julian Tillmann, Christine Ecker, Flavio Dellâ€™Acqua, Daniel Brandeis, Tobias Banaschewski, Sarah Baumeister, Carolin Moessnang, Simon Baron-Cohen, Rosemary Holt, Sven BÃ¶lte, Sarah Durston, Prantik Kundu, Michael V. Lombardo, Will Spooren, Eva Loth, Declan G.M. Murphy, Christian F. Beckmann, Jan K. Buitelaar, Jumana Ahmad, Sara A Altered Connectivity Between Cerebellum, Visual, and Sensory-Motor Networks in Autism Spectrum Disorder: Results from the EU-AIMS Longitudinal European Autism Project published pages: 260-270, ISSN: 2451-9022, DOI: 10.1016/j.bpsc.2018.11.010	Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 4/3	2020-01-30
2019	Michael V. Lombardo, Bonnie Auyeung, Tiziano Pramparo, AngÃ©lique Quartier, JÃ©rÃ©mie Courraud, Rosemary J. Holt, Jack Waldman, Amber N. V. Ruigrok, Natasha Mooney, Richard A. I. Bethlehem, Meng-Chuan Lai, Prantik Kundu, Edward T. Bullmore, Jean-Louis Mandel, AmÃ©lie Piton, Simon Baron-Cohen Sex-specific impact of prenatal androgens on social brain default mode subsystems published pages: , ISSN: 1359-4184, DOI: 10.1038/s41380-018-0198-y	Molecular Psychiatry	2020-01-30
2018	Meng-Chuan Lai, Michael V Lombardo, Bhismadev Chakrabarti, Amber NV Ruigrok, Edward T Bullmore, John Suckling, Bonnie Auyeung, Francesca HappÃ©, Peter Szatmari, Simon Baron-Cohen, Anthony J Bailey, Patrick F Bolton, Sarah Carrington, Marco Catani, Michael C Craig, Eileen M Daly, Sean CL Deoni, Christine Ecker, Julian Henty, Peter Jezzard, Patrick Johnston, Derek K Jones, Anya Madden, Diane Mullins Neural self-representation in autistic women and association with â€˜compensatory camouflagingâ€™ published pages: 136236131880715, ISSN: 1362-3613, DOI: 10.1177/1362361318807159	Autism	2020-01-30
2018	Michael V. Lombardo, Tiziano Pramparo, Vahid Gazestani, Varun Warrier, Richard A. I. Bethlehem, Cynthia Carter Barnes, Linda Lopez, Nathan E. Lewis, Lisa Eyler, Karen Pierce, Eric Courchesne Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes published pages: 1680-1688, ISSN: 1097-6256, DOI: 10.1038/s41593-018-0281-3	Nature Neuroscience 21/12	2020-01-30
2018	Juan M. GÃ³rriz, Javier RamÃrez, F. Segovia, Francisco J. MartÃnez, Meng-Chuan Lai, Michael V. Lombardo, Simon Baron-Cohen, John Suckling A Machine Learning Approach to Reveal the NeuroPhenotypes of Autisms published pages: 1850058, ISSN: 0129-0657, DOI: 10.1142/s0129065718500582	International Journal of Neural Systems	2020-01-30
2018	Caroline Mann, Anke Bletsch, Derek Andrews, Eileen Daly, Clodagh Murphy, Declan Murphy, Christine Ecker The effect of age on vertex-based measures of the grey-white matter tissue contrast in autism spectrum disorder published pages: , ISSN: 2040-2392, DOI: 10.1186/s13229-018-0232-6	Molecular Autism 9/1	2020-01-30
2019	Michael V. Lombardo, Meng-Chuan Lai, Simon Baron-Cohen Big data approaches to decomposing heterogeneity across the autism spectrum published pages: , ISSN: 1359-4184, DOI: 10.1038/s41380-018-0321-0	Molecular Psychiatry	2020-01-30

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