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StemCellHabitat SIGNED

Metabolic and Timed Control of Stem Cell Fate in the Developing Animal

Total Cost €

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EC-Contrib. €

0

Partnership

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 StemCellHabitat project word cloud

Explore the words cloud of the StemCellHabitat project. It provides you a very rough idea of what is the project "StemCellHabitat" about.

decisions    stereotypical    cues    regulates    provides    regulation    age    live    progeny    drosophila    details    brain    physiological    metabolic    nb    tumors    previously    neurons    contributes    lineage    found    eukaryotes    metabolically    metabolite    dynamically    generation    combining    mechanistic    dissect    first    cells    unlimited    occurs    additional    model    positions    integrative    genetics    oxidative    stem    mechanisms    stage    right    phosphorylation    question    animal    types    integrating    regulate    sc    waves    highlighting    evident    time    unclear    little    regulator    tight    multidisciplinary    fantastic    directing    disappear    answer    neuroblasts    formed    levels    correct    melanogaster    fixed    proliferation    organism    fate    omics    regulated    combination    complexity    exit    dynamics    neural    temporal    spatial    scs    nbs    cycle    metabolism    3d    sorting    proper    developmental    hormones    cell    transcription    temporally    imaging   

Project "StemCellHabitat" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDADE NOVA DE LISBOA 

Organization address
address: CAMPUS DE CAMPOLIDE
city: LISBOA
postcode: 1099 085
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 1˙697˙493 €
 EC max contribution 1˙697˙493 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-02-01   to  2023-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDADE NOVA DE LISBOA PT (LISBOA) coordinator 1˙017˙858.00
2    INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLOGICA PT (OEIRAS) participant 679˙635.00

Map

 Project objective

Stem cell (SC) proliferation during development requires tight spatial and temporal regulation to ensure correct cell number and right cell types are formed at the proper positions. Currently very little is known about how SCs are regulated during development. Specifically, it is unclear how SC waves of proliferation are regulated and how the fate of their progeny changes during development. In addition, it has recently become evident that metabolism provides additional complexity in cell fate regulation, highlighting the need for integrating metabolic information across physiological levels. This project will answer the question of how the combination of metabolic state and temporal cues (animal developmental stage) regulate SC fate. I will use Drosophila melanogaster, an animal complex enough to be similar to higher eukaryotes and yet simple enough to dissect the mechanistic details of cell regulation and its impact on the organism. Drosophila neural stem cells, the neuroblasts (NB), are a fantastic model of temporally and metabolically regulated cells. NB lineage fate changes with time, directing the generation of a stereotypical set of neurons, after which they disappear. I have previously found that metabolism is an important regulator of NB cell cycle exit, which occurs in response to an increase in levels of oxidative phosphorylation. Using a multidisciplinary approach combining genetics, cell type/age sorting, multi-omics analysis, fixed and 3D-live NB imaging and metabolite dynamics, I propose an integrative approach to investigate how NBs are regulated in the developing animal. First I will dissect the mechanisms by which metabolism regulates NB fate. Second, I will investigate how metabolism contributes to NB unlimited proliferation and brain tumors. Finally, we will address how temporal transcription factors and hormones dynamically affect cell fate decisions during development.

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The information about "STEMCELLHABITAT" are provided by the European Opendata Portal: CORDIS opendata.

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