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NANOSTORM SIGNED

Design of Nanomaterials for Targeted Therapies Guided by Super Resolution Imaging

Total Cost €

EC-Contrib. €

Partnership

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NANOSTORM project word cloud

Explore the words cloud of the NANOSTORM project. It provides you a very rough idea of what is the project "NANOSTORM" about.

guide vitro relations unprecedented treatment single lack date biological reported prostate generation therapy nanometric principles imaging self therapies diseased resolution structure actively technique nanomaterials molecular translation stochastic unsatisfactory assembled cells nanotechnology unveil interactions revolutionized nanostructures materials proposes approved optical super therapeutic cellular drug interdisciplinary introducing environment nanostorm investigation rational synthesized visualize carriers microscopy despite recognition extremely reconstruction cancer understand first molecule investments image synthetic framework arising formulation time storm innovative clinical

Project "NANOSTORM" data sheet

The following table provides information about the project.

Coordinator	TECHNISCHE UNIVERSITEIT EINDHOVEN Organization address address: GROENE LOPER 3 city: EINDHOVEN postcode: 5612 AE website: www.tue.nl/en contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Total cost	1˙497˙588 €
EC max contribution	1˙497˙588 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-STG
Funding Scheme	ERC-STG
Starting year	2018
Duration (year-month-day)	from 2018-02-01 to 2023-01-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	TECHNISCHE UNIVERSITEIT EINDHOVEN TECHNISCHE UNIVERSITEIT EINDHOVEN Organization address address: GROENE LOPER 3 city: EINDHOVEN postcode: 5612 AE website: www.tue.nl/en contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (EINDHOVEN)	coordinator	1˙237˙588.00
2	FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA Organization address address: CARRER BALDIRI REIXAC PLANTA 2A 10-12 city: BARCELONA postcode: 8028 website: http://www.ibecbarcelona.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	260˙000.00

Map

Project objective

Nanomaterials revolutionized the field of targeted cancer therapies introducing innovative approaches towards the molecular recognition of diseased cells. However, despite the large investments in nanotechnology-based drug delivery the translation into clinical applications is still unsatisfactory and up to date there are no actively-targeted materials approved for clinical use. One of the main reasons is the lack of knowledge about the behaviour of nanostructures in the biological environment that makes the rational design of effective drug delivery carriers extremely challenging.

NANOSTORM proposes the use of an innovative optical imaging technique such as super resolution microscopy to visualize and understand the molecular interactions of nanomaterials with their cellular targets in unprecedented detail. We recently reported for the first time the ability of Stochastic Optical Reconstruction Microscopy (STORM) to image self-assembled synthetic materials in vitro with nanometric resolution. NANOSTORM aims to bring this to the next level, using STORM to unveil the structure-activity relations of therapeutic nanomaterials in the biological environment at the single molecule level. The knowledge arising from this investigation will provide novel design principles for the next generation of nanomaterials for targeted therapies. In particular, in the framework of NANOSTORM novel nanomaterials for the targeted treatment of prostate cancer will be synthesized and evaluated. This interdisciplinary research program will advance our understanding of nanostructures for targeted drug delivery and guide the formulation of novel materials for cancer therapy.

Publications

List of publications.
year	authors and title	journal	last update
2019	R. A. J. Post, D. van der Zwaag, G. Bet, S. P. W. Wijnands, L. Albertazzi, E. W. Meijer, R. W. van der Hofstad A stochastic view on surface inhomogeneity of nanoparticles published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-09595-y	Nature Communications 10/1	2019-10-01
2019	Silvia Pujals, Lorenzo Albertazzi Super-resolution Microscopy for Nanomedicine Research published pages: , ISSN: 1936-0851, DOI: 10.1021/acsnano.9b05289	ACS Nano	2019-10-01
2019	Annasaheb Kolpe, Maria Arista-Romero, Bert Schepens, Silvia Pujals, Xavier Saelens, Lorenzo Albertazzi Super-resolution microscopy reveals significant impact of M2e-specific monoclonal antibodies on influenza A virus filament formation at the host cell surface published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-41023-5	Scientific Reports 9/1	2019-10-01

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